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• W1978721061 abstract "Abstract: Allogeneic HSCT is a curative treatment, when chemotherapy fails, for certain malignant diseases. In Europe, only 15% of the indicated children have an HLA-matched sibling available; in 65–70% of others, HLA allele-matched (9–10/10) UDs can be identified. For the rest, it is necessary to identify other alternative donors (HLA-mismatched family or unrelated cord blood). We present our data of HSCT using HLA partially allele-mismatched (7–8/10) UDs in 24 children with leukemia. Uniform GvHD prophylaxis was used (rATG, CsA and MTX). Acute GvHD grade II was diagnosed in 70.8% of the patients and grade III–IV in 12.5%. Overall incidence of chronic GvHD was 38.7% (extensive in 30%). The probability of EFS was 60.3% (95% CI 35.5–78.1) and OS was 74.9 (95% CI 49.1–88.9). No difference in survival between PBSC and BM recipients was observed. TRM at day + 100 was 4%, and overall was 12.5%. We conclude that used combination of drugs for GvHD prophylaxis is efficient even for patients transplanted with grafts from a HLA-mismatched UDs. It enables stable engraftment, good control of GvHD, full reconstitution of immunity, and is not connected with unacceptable transplant-related mortality." @default.
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• W1978721061 date "2008-02-01" @default.
• W1978721061 modified "2023-10-16" @default.
• W1978721061 title "Allogeneic stem cell transplantation in children with leukemia using human leukocyte antigen-mismatched unrelated donors" @default.
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• W1978721061 doi "https://doi.org/10.1111/j.1399-3046.2007.00762.x" @default.
• W1978721061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18186885" @default.
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