Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978721215> ?p ?o ?g. }
- W1978721215 endingPage "367" @default.
- W1978721215 startingPage "357" @default.
- W1978721215 abstract "Small soluble oligomers, and dimers in particular, of the amyloid β-peptide (Aβ) are believed to play an important pathological role in Alzheimer's disease. Here, we investigate the spontaneous dimerization of Aβ42, with 42 residues, by implicit solvent all-atom Monte Carlo simulations, for the wild-type peptide and the mutants F20E, E22G and E22G/I31E. The observed dimers of these variants share many overall conformational characteristics but differ in several aspects at a detailed level. In all four cases, the most common type of secondary structure is intramolecular antiparallel β-sheets. Parallel, in-register β-sheet structure, as in models for Aβ fibrils, is rare. The primary force driving the formation of dimers is hydrophobic attraction. The conformational differences that we do see involve turns centered in the 20–30 region. The probability of finding turns centered in the 25–30 region, where there is a loop in Aβ fibrils, is found to increase upon dimerization and to correlate with experimentally measured rates of fibril formation for the different Aβ42 variants. Our findings hint at reorganization of this part of the molecule as a potentially critical step in Aβ aggregation." @default.
- W1978721215 created "2016-06-24" @default.
- W1978721215 creator A5060442147 @default.
- W1978721215 creator A5060577157 @default.
- W1978721215 creator A5083509237 @default.
- W1978721215 creator A5083811644 @default.
- W1978721215 date "2011-07-01" @default.
- W1978721215 modified "2023-09-25" @default.
- W1978721215 title "Monte Carlo Study of the Formation and Conformational Properties of Dimers of Aβ42 Variants" @default.
- W1978721215 cites W1552415503 @default.
- W1978721215 cites W1595368494 @default.
- W1978721215 cites W1617188648 @default.
- W1978721215 cites W1964758432 @default.
- W1978721215 cites W1965895512 @default.
- W1978721215 cites W1969099023 @default.
- W1978721215 cites W1972535964 @default.
- W1978721215 cites W1973479349 @default.
- W1978721215 cites W1976208596 @default.
- W1978721215 cites W1976430960 @default.
- W1978721215 cites W1978314140 @default.
- W1978721215 cites W1980146626 @default.
- W1978721215 cites W1981458288 @default.
- W1978721215 cites W1981735680 @default.
- W1978721215 cites W1983628095 @default.
- W1978721215 cites W1995266981 @default.
- W1978721215 cites W1996037698 @default.
- W1978721215 cites W2001148193 @default.
- W1978721215 cites W2008151389 @default.
- W1978721215 cites W2024473468 @default.
- W1978721215 cites W2029695041 @default.
- W1978721215 cites W2035385837 @default.
- W1978721215 cites W2035963355 @default.
- W1978721215 cites W2040560106 @default.
- W1978721215 cites W2060449809 @default.
- W1978721215 cites W2067214887 @default.
- W1978721215 cites W2089435371 @default.
- W1978721215 cites W2100610977 @default.
- W1978721215 cites W2109727228 @default.
- W1978721215 cites W2114078421 @default.
- W1978721215 cites W2117859952 @default.
- W1978721215 cites W2121374178 @default.
- W1978721215 cites W2122294662 @default.
- W1978721215 cites W2124097456 @default.
- W1978721215 cites W2132188964 @default.
- W1978721215 cites W2137261793 @default.
- W1978721215 cites W2141920771 @default.
- W1978721215 cites W2143264455 @default.
- W1978721215 cites W2149060580 @default.
- W1978721215 cites W2157693914 @default.
- W1978721215 cites W2160770834 @default.
- W1978721215 cites W2166427101 @default.
- W1978721215 cites W2166848357 @default.
- W1978721215 cites W3098405609 @default.
- W1978721215 doi "https://doi.org/10.1016/j.jmb.2011.05.014" @default.
- W1978721215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21616081" @default.
- W1978721215 hasPublicationYear "2011" @default.
- W1978721215 type Work @default.
- W1978721215 sameAs 1978721215 @default.
- W1978721215 citedByCount "49" @default.
- W1978721215 countsByYear W19787212152012 @default.
- W1978721215 countsByYear W19787212152013 @default.
- W1978721215 countsByYear W19787212152014 @default.
- W1978721215 countsByYear W19787212152015 @default.
- W1978721215 countsByYear W19787212152016 @default.
- W1978721215 countsByYear W19787212152017 @default.
- W1978721215 countsByYear W19787212152018 @default.
- W1978721215 countsByYear W19787212152019 @default.
- W1978721215 countsByYear W19787212152020 @default.
- W1978721215 crossrefType "journal-article" @default.
- W1978721215 hasAuthorship W1978721215A5060442147 @default.
- W1978721215 hasAuthorship W1978721215A5060577157 @default.
- W1978721215 hasAuthorship W1978721215A5083509237 @default.
- W1978721215 hasAuthorship W1978721215A5083811644 @default.
- W1978721215 hasConcept C105795698 @default.
- W1978721215 hasConcept C115260700 @default.
- W1978721215 hasConcept C121332964 @default.
- W1978721215 hasConcept C12554922 @default.
- W1978721215 hasConcept C142089489 @default.
- W1978721215 hasConcept C147597530 @default.
- W1978721215 hasConcept C185592680 @default.
- W1978721215 hasConcept C19499675 @default.
- W1978721215 hasConcept C27523624 @default.
- W1978721215 hasConcept C2779281246 @default.
- W1978721215 hasConcept C33923547 @default.
- W1978721215 hasConcept C55493867 @default.
- W1978721215 hasConcept C59593255 @default.
- W1978721215 hasConcept C62520636 @default.
- W1978721215 hasConcept C71240020 @default.
- W1978721215 hasConcept C75079739 @default.
- W1978721215 hasConcept C8010536 @default.
- W1978721215 hasConcept C86803240 @default.
- W1978721215 hasConceptScore W1978721215C105795698 @default.
- W1978721215 hasConceptScore W1978721215C115260700 @default.
- W1978721215 hasConceptScore W1978721215C121332964 @default.
- W1978721215 hasConceptScore W1978721215C12554922 @default.
- W1978721215 hasConceptScore W1978721215C142089489 @default.
- W1978721215 hasConceptScore W1978721215C147597530 @default.
- W1978721215 hasConceptScore W1978721215C185592680 @default.