FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978726274> ?p ?o ?g. }

• W1978726274 endingPage "750" @default.
• W1978726274 startingPage "742" @default.
• W1978726274 abstract "The filamentous fungus Aspergillus nidulans nudC gene has an essential function in movement of nuclei following mitosis and is required for normal colony growth. Here, the molecular cloning and role in hematopoiesis of a human gene (designated HnudC) homologous to A. nidulans nudC is reported. The amino terminus of the larger human protein (HNUDC = 45 kDa) does not overlap with A. nidulans NUDC (22 kDa). However, NUDC and the C-terminal 94 amino acids of HNUDC are 67% identical. The C-terminal region of the HnudC gene fully complements the A. nidulans temperature-sensitive nudC3 mutation, suggesting that nudC has an essential function in cell growth that is conserved from filamentous fungi to humans. In initial studies, HNUDC levels were much higher in erythroid precursors compared to most other human tissues. Therefore, the potential role of HnudC in hematopoiesis was explored. In normal human bone marrow, HNUDC protein and mRNA are highly expressed in early myeloid and erythroid precursors and decline as these cells terminally differentiate. To determine whether hematopoietic growth factors induce HnudC expression, TF-1 cells were stimulated by granulocyte-macrophage colony-stimulating factor. This induced a significant increase in HNUDC protein and HnudC mRNA, suggesting that enhancement of HnudC expression in response to growth factor stimulation may be mediated at the transcription level. Furthermore, HNUDC was significantly enhanced in lysates of bone marrow aspirates from patients with acute myelogenous and acute lymphoblastic leukemia compared to aspirates from normal controls, suggesting that HnudC is involved in malignant hematopoietic cell growth as well. These data demonstrate that HNUDC is highly expressed in normal and malignant human hematopoietic precursors and suggest it is of functional importance in the proliferation of these cells." @default.
• W1978726274 created "2016-06-24" @default.
• W1978726274 creator A5009694357 @default.
• W1978726274 creator A5020678445 @default.
• W1978726274 creator A5021303868 @default.
• W1978726274 creator A5026776372 @default.
• W1978726274 creator A5034429217 @default.
• W1978726274 creator A5035529341 @default.
• W1978726274 creator A5042437739 @default.
• W1978726274 creator A5050544406 @default.
• W1978726274 creator A5066913752 @default.
• W1978726274 date "1999-04-01" @default.
• W1978726274 modified "2023-10-16" @default.
• W1978726274 title "A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis" @default.
• W1978726274 cites W1520102740 @default.
• W1978726274 cites W1574250061 @default.
• W1978726274 cites W1880424252 @default.
• W1978726274 cites W1983575076 @default.
• W1978726274 cites W1986238762 @default.
• W1978726274 cites W1992203199 @default.
• W1978726274 cites W1995282840 @default.
• W1978726274 cites W2011572906 @default.
• W1978726274 cites W2013654613 @default.
• W1978726274 cites W2016730049 @default.
• W1978726274 cites W2023281151 @default.
• W1978726274 cites W2039733776 @default.
• W1978726274 cites W2051831012 @default.
• W1978726274 cites W2058219169 @default.
• W1978726274 cites W2076241227 @default.
• W1978726274 cites W2095790288 @default.
• W1978726274 cites W2120375547 @default.
• W1978726274 cites W2149228617 @default.
• W1978726274 cites W2161045200 @default.
• W1978726274 cites W2298241193 @default.
• W1978726274 cites W4256538244 @default.
• W1978726274 doi "https://doi.org/10.1016/s0301-472x(98)00074-5" @default.
• W1978726274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10210332" @default.
• W1978726274 hasPublicationYear "1999" @default.
• W1978726274 type Work @default.
• W1978726274 sameAs 1978726274 @default.
• W1978726274 citedByCount "38" @default.
• W1978726274 countsByYear W19787262742012 @default.
• W1978726274 countsByYear W19787262742014 @default.
• W1978726274 countsByYear W19787262742015 @default.
• W1978726274 countsByYear W19787262742016 @default.
• W1978726274 countsByYear W19787262742017 @default.
• W1978726274 countsByYear W19787262742021 @default.
• W1978726274 countsByYear W19787262742022 @default.
• W1978726274 crossrefType "journal-article" @default.
• W1978726274 hasAuthorship W1978726274A5009694357 @default.
• W1978726274 hasAuthorship W1978726274A5020678445 @default.
• W1978726274 hasAuthorship W1978726274A5021303868 @default.
• W1978726274 hasAuthorship W1978726274A5026776372 @default.
• W1978726274 hasAuthorship W1978726274A5034429217 @default.
• W1978726274 hasAuthorship W1978726274A5035529341 @default.
• W1978726274 hasAuthorship W1978726274A5042437739 @default.
• W1978726274 hasAuthorship W1978726274A5050544406 @default.
• W1978726274 hasAuthorship W1978726274A5066913752 @default.
• W1978726274 hasBestOaLocation W19787262741 @default.
• W1978726274 hasConcept C104317684 @default.
• W1978726274 hasConcept C109159458 @default.
• W1978726274 hasConcept C143065580 @default.
• W1978726274 hasConcept C150194340 @default.
• W1978726274 hasConcept C153911025 @default.
• W1978726274 hasConcept C2776923806 @default.
• W1978726274 hasConcept C2779282312 @default.
• W1978726274 hasConcept C28328180 @default.
• W1978726274 hasConcept C502942594 @default.
• W1978726274 hasConcept C54355233 @default.
• W1978726274 hasConcept C86803240 @default.
• W1978726274 hasConcept C95444343 @default.
• W1978726274 hasConceptScore W1978726274C104317684 @default.
• W1978726274 hasConceptScore W1978726274C109159458 @default.
• W1978726274 hasConceptScore W1978726274C143065580 @default.
• W1978726274 hasConceptScore W1978726274C150194340 @default.
• W1978726274 hasConceptScore W1978726274C153911025 @default.
• W1978726274 hasConceptScore W1978726274C2776923806 @default.
• W1978726274 hasConceptScore W1978726274C2779282312 @default.
• W1978726274 hasConceptScore W1978726274C28328180 @default.
• W1978726274 hasConceptScore W1978726274C502942594 @default.
• W1978726274 hasConceptScore W1978726274C54355233 @default.
• W1978726274 hasConceptScore W1978726274C86803240 @default.
• W1978726274 hasConceptScore W1978726274C95444343 @default.
• W1978726274 hasIssue "4" @default.
• W1978726274 hasLocation W19787262741 @default.
• W1978726274 hasLocation W19787262742 @default.
• W1978726274 hasOpenAccess W1978726274 @default.
• W1978726274 hasPrimaryLocation W19787262741 @default.
• W1978726274 hasRelatedWork W1837026174 @default.
• W1978726274 hasRelatedWork W1977580305 @default.
• W1978726274 hasRelatedWork W2009966535 @default.
• W1978726274 hasRelatedWork W2019988726 @default.
• W1978726274 hasRelatedWork W2058637601 @default.
• W1978726274 hasRelatedWork W2082530227 @default.
• W1978726274 hasRelatedWork W2088063203 @default.
• W1978726274 hasRelatedWork W2119511363 @default.
• W1978726274 hasRelatedWork W2171277769 @default.
• W1978726274 hasRelatedWork W2235407174 @default.

• next