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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978730308> ?p ?o ?g. }

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• W1978730308 abstract "MicroRNAs (miRNAs) have emerged as important regulators in the development of pancreatic cancer and may be a valuable therapeutic application. DPC4/Smad4 is a critical tumor suppressor involved in the progression of pancreatic cancer, but few studies have been conducted to determine its relationship with miRNAs. In this study, we identify miR-421 as a potential regulator of DPC4/Smad4. We find that in human clinical specimens of pancreatic cancer miR-421 is aberrantly upregulated while DPC4/Smad4 is strongly repressed, and their levels of expression are inversely correlated. Moreover, ectopic expression of miR-421 significantly decreases DPC4/Smad4 protein level in pancreatic cancer cell lines and simultaneously promotes cell proliferation and colony formation in vitro. Our findings identify miR-421 as a potent regulator of DPC4/Smad4, which may provide a novel therapeutic strategy for treatment of DPC4/Smad4-driven pancreatic cancer." @default.
• W1978730308 created "2016-06-24" @default.
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• W1978730308 date "2011-03-01" @default.
• W1978730308 modified "2023-10-01" @default.
• W1978730308 title "MicroRNA 421 suppresses DPC4/Smad4 in pancreatic cancer" @default.
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• W1978730308 doi "https://doi.org/10.1016/j.bbrc.2011.02.086" @default.
• W1978730308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21352803" @default.
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