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- W1978732006 abstract "Abstract Biomimetic formation of extracellular matrix (ECM) like coatings on artificial biomaterials provides a promising route to gain bioactive materials for tissue engineering applications. Organic ECM is also a template for apatite mineralization in bone tissue. This study was aimed at designing a multilayer film containing an ECM-like molecule on biomaterial surfaces to direct apatite mineralization and to develop biomimetic biomaterials for bone tissue engineering. A multilayer film consisting of gelatin and poly(ethylenimine) molecules was formed on a poly(L-lactic acid) substrate via electrostatic self-assembly technique. Bonelike apatite coating was formed on the multilayer film modified poly(L-lactic acid) substrate in simulated body fluids (SBFs). The amount of forming apatite could be controlled by the Ca2+ and HPO4 2- concentrations in SBF and also through the mineralization time. Gelatin terminated multilayer film can induce the apatite formation with a weak orientation in the (002) plane and the apatite is similar in composition to the natural bone. The gelatin multilayer film/apatite composite coating may serve as a promising microenvironment for bone tissue formation and growth." @default.
- W1978732006 created "2016-06-24" @default.
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- W1978732006 date "2010-12-01" @default.
- W1978732006 modified "2023-10-18" @default.
- W1978732006 title "Development of synthetic extracellular bone matrix on poly(L-lactic acid) substrates via electrostatic selfassembly and biomimetic mineralization technologies" @default.
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- W1978732006 doi "https://doi.org/10.1515/epoly.2010.10.1.630" @default.
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