Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978733145> ?p ?o ?g. }
- W1978733145 endingPage "339" @default.
- W1978733145 startingPage "324" @default.
- W1978733145 abstract "Abstract Robust methods that monitor enzyme activity and inhibitor potency are crucial to drug discovery and development. Over the past 20 years, mass spectrometric methods have increasingly been used to measure enzyme activity and kinetics. However, for rapid screening of inhibitory compounds, various forms of fluorescence and chemiluminscence readout have continued to dominate the market. As the sensitivity, speed, and miniaturization of mass spectrometry methods continue to advance, opportunities to couple mass spectrometry with screening will continue to come to the forefront. To appreciate the tremendous potential for MS‐based screening assays, it becomes necessary to understand the current state of capabilities in this arena. Thus, this review is intended to capture how mass spectrometry for studying enzymes activity has progressed from simple qualitative questions (i.e., is the product detected?) to quantitative measures of enzyme activity and kinetics and then as a tool for rapidly screening inhibitory compounds as an alternative to current methods of high throughput drug screening. © 2007 Wiley Periodicals, Inc., Mass Spec Rev" @default.
- W1978733145 created "2016-06-24" @default.
- W1978733145 creator A5025546833 @default.
- W1978733145 date "2007-04-02" @default.
- W1978733145 modified "2023-10-14" @default.
- W1978733145 title "Mass spectrometry for enzyme assays and inhibitor screening: An emerging application in pharmaceutical research" @default.
- W1978733145 cites W1498039710 @default.
- W1978733145 cites W186238387 @default.
- W1978733145 cites W1963528695 @default.
- W1978733145 cites W1965302510 @default.
- W1978733145 cites W1965868814 @default.
- W1978733145 cites W1968361672 @default.
- W1978733145 cites W1969932702 @default.
- W1978733145 cites W1974185452 @default.
- W1978733145 cites W1974239998 @default.
- W1978733145 cites W1974830441 @default.
- W1978733145 cites W1975198055 @default.
- W1978733145 cites W1977151767 @default.
- W1978733145 cites W1977184198 @default.
- W1978733145 cites W1978785433 @default.
- W1978733145 cites W1979516078 @default.
- W1978733145 cites W1979575164 @default.
- W1978733145 cites W1991426846 @default.
- W1978733145 cites W1991909685 @default.
- W1978733145 cites W1992060322 @default.
- W1978733145 cites W1993857868 @default.
- W1978733145 cites W1993934748 @default.
- W1978733145 cites W1995633131 @default.
- W1978733145 cites W1996366920 @default.
- W1978733145 cites W1996525310 @default.
- W1978733145 cites W1998192315 @default.
- W1978733145 cites W1999303907 @default.
- W1978733145 cites W1999808576 @default.
- W1978733145 cites W2002058526 @default.
- W1978733145 cites W2002997454 @default.
- W1978733145 cites W2006478024 @default.
- W1978733145 cites W2007028399 @default.
- W1978733145 cites W2008789019 @default.
- W1978733145 cites W2009211602 @default.
- W1978733145 cites W2009364448 @default.
- W1978733145 cites W2009835186 @default.
- W1978733145 cites W2010026236 @default.
- W1978733145 cites W2010338295 @default.
- W1978733145 cites W2010732671 @default.
- W1978733145 cites W2011634783 @default.
- W1978733145 cites W2013337977 @default.
- W1978733145 cites W2013861694 @default.
- W1978733145 cites W2020699530 @default.
- W1978733145 cites W2022988743 @default.
- W1978733145 cites W2025610163 @default.
- W1978733145 cites W2030795407 @default.
- W1978733145 cites W2031156213 @default.
- W1978733145 cites W2031350798 @default.
- W1978733145 cites W2031796329 @default.
- W1978733145 cites W2034208469 @default.
- W1978733145 cites W2035106098 @default.
- W1978733145 cites W2035696576 @default.
- W1978733145 cites W2037610534 @default.
- W1978733145 cites W2037622735 @default.
- W1978733145 cites W2043096790 @default.
- W1978733145 cites W2044367277 @default.
- W1978733145 cites W2046424545 @default.
- W1978733145 cites W2046449108 @default.
- W1978733145 cites W2049233440 @default.
- W1978733145 cites W2054921761 @default.
- W1978733145 cites W2056305858 @default.
- W1978733145 cites W2056919047 @default.
- W1978733145 cites W2057251269 @default.
- W1978733145 cites W2057313484 @default.
- W1978733145 cites W2057895543 @default.
- W1978733145 cites W2058558191 @default.
- W1978733145 cites W2061673315 @default.
- W1978733145 cites W2065032524 @default.
- W1978733145 cites W2067612033 @default.
- W1978733145 cites W2068412543 @default.
- W1978733145 cites W2073292063 @default.
- W1978733145 cites W2073611774 @default.
- W1978733145 cites W2077963235 @default.
- W1978733145 cites W2080508606 @default.
- W1978733145 cites W2081567246 @default.
- W1978733145 cites W2084395855 @default.
- W1978733145 cites W2084866742 @default.
- W1978733145 cites W2085827150 @default.
- W1978733145 cites W2088353352 @default.
- W1978733145 cites W2091277482 @default.
- W1978733145 cites W2093943071 @default.
- W1978733145 cites W2094603463 @default.
- W1978733145 cites W2098536490 @default.
- W1978733145 cites W2104556052 @default.
- W1978733145 cites W2108026176 @default.
- W1978733145 cites W2110174460 @default.
- W1978733145 cites W2111324452 @default.
- W1978733145 cites W2114200830 @default.
- W1978733145 cites W2117098825 @default.
- W1978733145 cites W2120340274 @default.
- W1978733145 cites W2123432454 @default.
- W1978733145 cites W2134461293 @default.
- W1978733145 cites W2148828869 @default.