FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978734646> ?p ?o ?g. }

• W1978734646 endingPage "307" @default.
• W1978734646 startingPage "302" @default.
• W1978734646 abstract "Abstract Prostaglandins have been shown to be involved in the suppression of contact hypersensitivity (CHS) by so-far ill understood mechanisms. T-cell migration across the lining of cytokine-activated endo-thelial cells (EC) is thought to be a central step in the initiation of CHS. The aim of our investigation was therefore to examine whether prosta-glandin E1 (PGE1) influences cytokine-induced TK-1 mouse T-cell lymphoma adhesion to eEnd.2 mouse endothelioma cells. Here, we report that PGE1 (10−12− 10−8 M) dose-dependently reduced TNFα-induccd T-cell binding, while TNFα-unstimulated adhesion was not affected. To test whether PGE, acted primarily on T-cells or on EC, they were separately pretreated with PGE, prior to the adhesion assay. Selective PGE1 pretreatment of eEnd.2, but not of TK-1 dose-dependenlly inhibited TNFα, stimulated T-cell adhesion. Since binding of TK-1 to TNFα-treated eEnd.2 is mediated by the interaction of ICAM-1 and VCAM-1 (on EC) with their receptors LFA-1 and VLA-4 (on T-cells), we further investigated whether PGE1 would modulate the expression of these molecules. FACS-analysis revealed PGE1 to inhibit TNFα-induced upregulation of ICAM-1, but not of VCAM-I on EC. Furthermore, constitutive LFA-1 and VLA-4 expression on T-cells was not affected by PGE1. We conclude that PGE1 supresses T-cell adhesion to EC by selectively inhibiting TNFα-induced upregulation of ICAM-1 on EC. This may be one mechanism by which prostaglandins suppress immune responses requiring T-cell EC interactions such as contact hypersensitivity in skin." @default.
• W1978734646 created "2016-06-24" @default.
• W1978734646 creator A5004446285 @default.
• W1978734646 creator A5009450784 @default.
• W1978734646 creator A5014368322 @default.
• W1978734646 creator A5020586285 @default.
• W1978734646 creator A5021464930 @default.
• W1978734646 creator A5036752125 @default.
• W1978734646 creator A5054851880 @default.
• W1978734646 creator A5062533879 @default.
• W1978734646 date "1995-10-01" @default.
• W1978734646 modified "2023-09-26" @default.
• W1978734646 title "Prostaglandin E1 inhibits TNFalpha-induced T-cell adhesion to endothelial cells by selective down-modulation of ICAM-1 expression on endothelial cells*" @default.
• W1978734646 cites W1519008651 @default.
• W1978734646 cites W1548820511 @default.
• W1978734646 cites W1789059667 @default.
• W1978734646 cites W1965972035 @default.
• W1978734646 cites W1982281794 @default.
• W1978734646 cites W2011723257 @default.
• W1978734646 cites W2038619718 @default.
• W1978734646 cites W2072923264 @default.
• W1978734646 cites W2080492971 @default.
• W1978734646 cites W2081120186 @default.
• W1978734646 cites W2083797090 @default.
• W1978734646 cites W2089222693 @default.
• W1978734646 cites W2123248116 @default.
• W1978734646 cites W2133479688 @default.
• W1978734646 cites W2335919173 @default.
• W1978734646 cites W277330655 @default.
• W1978734646 cites W4252163819 @default.
• W1978734646 cites W4365364630 @default.
• W1978734646 doi "https://doi.org/10.1111/j.1600-0625.1995.tb00209.x" @default.
• W1978734646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8589921" @default.
• W1978734646 hasPublicationYear "1995" @default.
• W1978734646 type Work @default.
• W1978734646 sameAs 1978734646 @default.
• W1978734646 citedByCount "17" @default.
• W1978734646 countsByYear W19787346462013 @default.
• W1978734646 countsByYear W19787346462014 @default.
• W1978734646 countsByYear W19787346462018 @default.
• W1978734646 countsByYear W19787346462020 @default.
• W1978734646 crossrefType "journal-article" @default.
• W1978734646 hasAuthorship W1978734646A5004446285 @default.
• W1978734646 hasAuthorship W1978734646A5009450784 @default.
• W1978734646 hasAuthorship W1978734646A5014368322 @default.
• W1978734646 hasAuthorship W1978734646A5020586285 @default.
• W1978734646 hasAuthorship W1978734646A5021464930 @default.
• W1978734646 hasAuthorship W1978734646A5036752125 @default.
• W1978734646 hasAuthorship W1978734646A5054851880 @default.
• W1978734646 hasAuthorship W1978734646A5062533879 @default.
• W1978734646 hasConcept C104317684 @default.
• W1978734646 hasConcept C123012128 @default.
• W1978734646 hasConcept C127561419 @default.
• W1978734646 hasConcept C134018914 @default.
• W1978734646 hasConcept C1491633281 @default.
• W1978734646 hasConcept C153911025 @default.
• W1978734646 hasConcept C16224149 @default.
• W1978734646 hasConcept C170493617 @default.
• W1978734646 hasConcept C17991360 @default.
• W1978734646 hasConcept C185592680 @default.
• W1978734646 hasConcept C185946421 @default.
• W1978734646 hasConcept C202751555 @default.
• W1978734646 hasConcept C203014093 @default.
• W1978734646 hasConcept C2776985958 @default.
• W1978734646 hasConcept C2777198256 @default.
• W1978734646 hasConcept C2778690821 @default.
• W1978734646 hasConcept C2909375385 @default.
• W1978734646 hasConcept C502942594 @default.
• W1978734646 hasConcept C55493867 @default.
• W1978734646 hasConcept C85789140 @default.
• W1978734646 hasConcept C86803240 @default.
• W1978734646 hasConcept C95444343 @default.
• W1978734646 hasConceptScore W1978734646C104317684 @default.
• W1978734646 hasConceptScore W1978734646C123012128 @default.
• W1978734646 hasConceptScore W1978734646C127561419 @default.
• W1978734646 hasConceptScore W1978734646C134018914 @default.
• W1978734646 hasConceptScore W1978734646C1491633281 @default.
• W1978734646 hasConceptScore W1978734646C153911025 @default.
• W1978734646 hasConceptScore W1978734646C16224149 @default.
• W1978734646 hasConceptScore W1978734646C170493617 @default.
• W1978734646 hasConceptScore W1978734646C17991360 @default.
• W1978734646 hasConceptScore W1978734646C185592680 @default.
• W1978734646 hasConceptScore W1978734646C185946421 @default.
• W1978734646 hasConceptScore W1978734646C202751555 @default.
• W1978734646 hasConceptScore W1978734646C203014093 @default.
• W1978734646 hasConceptScore W1978734646C2776985958 @default.
• W1978734646 hasConceptScore W1978734646C2777198256 @default.
• W1978734646 hasConceptScore W1978734646C2778690821 @default.
• W1978734646 hasConceptScore W1978734646C2909375385 @default.
• W1978734646 hasConceptScore W1978734646C502942594 @default.
• W1978734646 hasConceptScore W1978734646C55493867 @default.
• W1978734646 hasConceptScore W1978734646C85789140 @default.
• W1978734646 hasConceptScore W1978734646C86803240 @default.
• W1978734646 hasConceptScore W1978734646C95444343 @default.
• W1978734646 hasIssue "5" @default.
• W1978734646 hasLocation W19787346461 @default.
• W1978734646 hasLocation W19787346462 @default.
• W1978734646 hasOpenAccess W1978734646 @default.

• next