FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978736086> ?p ?o ?g. }

• W1978736086 endingPage "2853" @default.
• W1978736086 startingPage "2848" @default.
• W1978736086 abstract "Previous studies have demonstrated the development of cardiac fibrosis in aldosterone (Aldo)-salt hypertensive rats. Our aim was to determine the effects of Aldo and the Aldo receptor antagonist eplerenone (Epl) on in vivo mechanical properties of the carotid artery using echo-tracking system.Aldo was administered (1 microg/h) in uninephrectomized Sprague-Dawley rats (SD) receiving a high-salt diet from 8 to 12 weeks of age. Uninephrectomized control SD rats received a normal salt diet without Aldo. Three groups of Aldo-salt rats were treated with 1, 10, or 30 mg/kg(-1) x d(-1) of Epl by gavage. Elasticity was measured by elastic modulus (Einc)-wall stress curves using medial cross-sectional area (MCSA). The structure of the arterial wall was analyzed by histomorphometry (elastin and collagen), immunohistochemistry (EIIIA fibronectin, Fn), and Northern blot (collagens I and III). Aldo produced increased systolic arterial pressure, pulse pressure, Einc, MCSA, and EIIIA Fn with no change in wall stress or elastin and collagen densities compared with controls without Aldo. No differences in collagen mRNA levels were detected between groups. Epl blunted the increase in pulse pressure in Aldo rats and normalized Einc-wall stress curves, MCSA, and EIIIA Fn. These effects were dose dependent and not accompanied by a reduction in wall stress.Aldo is able to increase arterial stiffness associated with Fn accumulation, independently of wall stress. The preventive effects of Epl suggest a direct role for mineralocorticoid receptors in mechanical and structural alterations of large vessels in rat hyperaldosteronism." @default.
• W1978736086 created "2016-06-24" @default.
• W1978736086 creator A5054306538 @default.
• W1978736086 creator A5054480556 @default.
• W1978736086 creator A5060757272 @default.
• W1978736086 creator A5085844421 @default.
• W1978736086 creator A5087655089 @default.
• W1978736086 creator A5089469282 @default.
• W1978736086 date "2002-11-26" @default.
• W1978736086 modified "2023-10-11" @default.
• W1978736086 title "Increased Carotid Wall Elastic Modulus and Fibronectin in Aldosterone-Salt–Treated Rats" @default.
• W1978736086 cites W1499471108 @default.
• W1978736086 cites W1518760783 @default.
• W1978736086 cites W1964825408 @default.
• W1978736086 cites W1972003997 @default.
• W1978736086 cites W1986832438 @default.
• W1978736086 cites W1996259445 @default.
• W1978736086 cites W2032512398 @default.
• W1978736086 cites W2046383997 @default.
• W1978736086 cites W2048975965 @default.
• W1978736086 cites W2050729995 @default.
• W1978736086 cites W2062043328 @default.
• W1978736086 cites W2069374420 @default.
• W1978736086 cites W2089392247 @default.
• W1978736086 cites W2106015949 @default.
• W1978736086 cites W2116106734 @default.
• W1978736086 cites W2128353203 @default.
• W1978736086 cites W2133877420 @default.
• W1978736086 cites W2140739392 @default.
• W1978736086 cites W2141853115 @default.
• W1978736086 cites W2153953287 @default.
• W1978736086 cites W2162423860 @default.
• W1978736086 doi "https://doi.org/10.1161/01.cir.0000039328.33137.6c" @default.
• W1978736086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12451013" @default.
• W1978736086 hasPublicationYear "2002" @default.
• W1978736086 type Work @default.
• W1978736086 sameAs 1978736086 @default.
• W1978736086 citedByCount "208" @default.
• W1978736086 countsByYear W19787360862012 @default.
• W1978736086 countsByYear W19787360862013 @default.
• W1978736086 countsByYear W19787360862014 @default.
• W1978736086 countsByYear W19787360862015 @default.
• W1978736086 countsByYear W19787360862016 @default.
• W1978736086 countsByYear W19787360862017 @default.
• W1978736086 countsByYear W19787360862018 @default.
• W1978736086 countsByYear W19787360862019 @default.
• W1978736086 countsByYear W19787360862020 @default.
• W1978736086 countsByYear W19787360862021 @default.
• W1978736086 countsByYear W19787360862022 @default.
• W1978736086 countsByYear W19787360862023 @default.
• W1978736086 crossrefType "journal-article" @default.
• W1978736086 hasAuthorship W1978736086A5054306538 @default.
• W1978736086 hasAuthorship W1978736086A5054480556 @default.
• W1978736086 hasAuthorship W1978736086A5060757272 @default.
• W1978736086 hasAuthorship W1978736086A5085844421 @default.
• W1978736086 hasAuthorship W1978736086A5087655089 @default.
• W1978736086 hasAuthorship W1978736086A5089469282 @default.
• W1978736086 hasBestOaLocation W19787360861 @default.
• W1978736086 hasConcept C126322002 @default.
• W1978736086 hasConcept C134018914 @default.
• W1978736086 hasConcept C142724271 @default.
• W1978736086 hasConcept C185592680 @default.
• W1978736086 hasConcept C189135053 @default.
• W1978736086 hasConcept C189165786 @default.
• W1978736086 hasConcept C2776069600 @default.
• W1978736086 hasConcept C2778525890 @default.
• W1978736086 hasConcept C2779869378 @default.
• W1978736086 hasConcept C2780072264 @default.
• W1978736086 hasConcept C2780559512 @default.
• W1978736086 hasConcept C55493867 @default.
• W1978736086 hasConcept C71924100 @default.
• W1978736086 hasConcept C84393581 @default.
• W1978736086 hasConcept C86492073 @default.
• W1978736086 hasConceptScore W1978736086C126322002 @default.
• W1978736086 hasConceptScore W1978736086C134018914 @default.
• W1978736086 hasConceptScore W1978736086C142724271 @default.
• W1978736086 hasConceptScore W1978736086C185592680 @default.
• W1978736086 hasConceptScore W1978736086C189135053 @default.
• W1978736086 hasConceptScore W1978736086C189165786 @default.
• W1978736086 hasConceptScore W1978736086C2776069600 @default.
• W1978736086 hasConceptScore W1978736086C2778525890 @default.
• W1978736086 hasConceptScore W1978736086C2779869378 @default.
• W1978736086 hasConceptScore W1978736086C2780072264 @default.
• W1978736086 hasConceptScore W1978736086C2780559512 @default.
• W1978736086 hasConceptScore W1978736086C55493867 @default.
• W1978736086 hasConceptScore W1978736086C71924100 @default.
• W1978736086 hasConceptScore W1978736086C84393581 @default.
• W1978736086 hasConceptScore W1978736086C86492073 @default.
• W1978736086 hasIssue "22" @default.
• W1978736086 hasLocation W19787360861 @default.
• W1978736086 hasLocation W19787360862 @default.
• W1978736086 hasOpenAccess W1978736086 @default.
• W1978736086 hasPrimaryLocation W19787360861 @default.
• W1978736086 hasRelatedWork W2025877223 @default.
• W1978736086 hasRelatedWork W2046439174 @default.
• W1978736086 hasRelatedWork W2108548563 @default.
• W1978736086 hasRelatedWork W2114271630 @default.
• W1978736086 hasRelatedWork W2130764257 @default.

• next