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• W1978736101 endingPage "1889" @default.
• W1978736101 startingPage "1877" @default.
• W1978736101 abstract "In June 2008, the world's first whole tissue-engineered organ - the windpipe - was successfully transplanted into a 31-year-old lady, and about 18 months following surgery she is leading a near normal life without immunosuppression. This outcome has been achieved by employing three groundbreaking technologies of regenerative medicine: (i) a donor trachea first decellularized using a detergent (without denaturing the collagenous matrix), (ii) the two main autologous tracheal cells, namely mesenchymal stem cell derived cartilage-like cells and epithelial respiratory cells and (iii) a specifically designed bioreactor that reseed, before implantation, the in vitro pre-expanded and pre-differentiated autologous cells on the desired surfaces of the decellularized matrix. Given the long-term safety, efficacy and efforts using such a conventional approach and the potential advantages of regenerative implants to make them available for anyone, we have investigated a novel alternative concept how to fully avoid in vitro cell replication, expansion and differentiation, use the human native site as micro-niche, potentiate the human body's site-specific response by adding boosting, permissive and recruitment impulses in full respect of sociological and regulatory prerequisites. This tissue-engineered approach and ongoing research in airway transplantation is reviewed and presented here." @default.
• W1978736101 created "2016-06-24" @default.
• W1978736101 creator A5007596896 @default.
• W1978736101 creator A5049426698 @default.
• W1978736101 date "2010-07-01" @default.
• W1978736101 modified "2023-10-14" @default.
• W1978736101 title "Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach" @default.
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• W1978736101 doi "https://doi.org/10.1111/j.1582-4934.2010.01073.x" @default.
• W1978736101 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3823270" @default.
• W1978736101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20406329" @default.
• W1978736101 hasPublicationYear "2010" @default.
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