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• W1978736671 endingPage "1341" @default.
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• W1978736671 abstract "OBJECTIVES: To investigate the association of genetic polymorphisms of the interleukin-18 (IL-18) pathway to Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). Most cases of EAC arise in a background of reflux-induced BE. Genetic influences in this pathway are poorly understood. IL-18 is a multifunctional cytokine implicated in anti-tumor immunity. A number of polymorphisms of theIL-18and IL-18 receptor-accessory protein (IL-18RAP) genes have been reported to alter gene expression and have recently been linked to inflammatory processes and various tumors, but have not heretofore been studied in BE and EAC. METHODS: TwoIL-18promoter polymorphisms −137 G/C and −607 C/A, (rs187238 and rs1946518) and oneIL-18RAPpolymorphism (rs917997, C/T) were analyzed. Each single-nucleotide polymorphism (SNP) was genotyped in the following groups: EAC, BE, reflux esophagitis (RE), and controls and analyzed for association with disease status. RESULTS: TheIL-18RAPrs917997C allele is strongly associated with a protective effect in BE (P=0.0002) and EAC (P=6 × 10−7), which approaches genome-wide levels of significance for allele association without incurring significant multiple testing. The CC genotype atIL-18RAPlocus rs917997 was associated with a protective effect against esophageal disease (P=6 × 10−4, odds ratio (OR)=0.59, and 95% confidence interval (CI) 0.43–0.80 for BE; andP=2 × 10−6, OR=0.46, and 95% CI 0.34–0.64 for EAC). The genotype frequencies ofIL-18−607 C/A were weakly associated with BE (P=0.02), and this trend was also seen between controls and EAC (P=0.07). The CC genotype was associated with an increased risk of BE (OR=1.45, 95% CI 1.07–1.98) and approached significance for EAC (OR=1.34, 95% CI 0.98–1.82). Allele and genotype frequencies at these loci were not significantly different between the RE group and controls. Although no significant association was observed between the disease groups at the –137 G/C locus, the −137G/−607C haplotype was associated with increased risk of BE (P=0.006) with haplotype frequencies of 55% in controls and 65% in BE. CONCLUSIONS: These data show a strong association of theIL-18RAPSNP rs917997 locus with BE and EAC and suggestive association of the Barrett's population with theIL-18−607 C/A promoter polymorphism. As both of these SNPs have been demonstrated as expression quantitative trait loci affecting expression of the respective genes, this strongly implicatesIL-18signaling in susceptibility to BE and EAC." @default.
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• W1978736671 date "2012-09-01" @default.
• W1978736671 modified "2023-09-26" @default.
• W1978736671 title "Genes of the Interleukin-18 Pathway Are Associated With Susceptibility to Barrett's Esophagus and Esophageal Adenocarcinoma" @default.
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• W1978736671 cites W2009927359 @default.
• W1978736671 cites W2012536766 @default.
• W1978736671 cites W2014847336 @default.
• W1978736671 cites W2015141578 @default.
• W1978736671 cites W2024836545 @default.
• W1978736671 cites W2025220727 @default.
• W1978736671 cites W2028970064 @default.
• W1978736671 cites W2029544111 @default.
• W1978736671 cites W2033036320 @default.
• W1978736671 cites W2034474453 @default.
• W1978736671 cites W2040136700 @default.
• W1978736671 cites W2041823235 @default.
• W1978736671 cites W2044162906 @default.
• W1978736671 cites W2061446718 @default.
• W1978736671 cites W2063307907 @default.
• W1978736671 cites W2073243487 @default.
• W1978736671 cites W2076854360 @default.
• W1978736671 cites W2078416432 @default.
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• W1978736671 cites W2095698281 @default.
• W1978736671 cites W2096621446 @default.
• W1978736671 cites W2100701027 @default.
• W1978736671 cites W2104297616 @default.
• W1978736671 cites W2106448631 @default.
• W1978736671 cites W2109555099 @default.
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• W1978736671 cites W2121369239 @default.
• W1978736671 cites W2121415355 @default.
• W1978736671 cites W2122534786 @default.
• W1978736671 cites W2122973522 @default.
• W1978736671 cites W2124899473 @default.
• W1978736671 cites W2131678280 @default.
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• W1978736671 doi "https://doi.org/10.1038/ajg.2012.134" @default.
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