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• W1978736897 abstract "Uncovering primary target antigens in multiple sclerosis (MS) is of major significance for understanding the etiology and pathophysiology of the disease, and for designing immunospecific therapy. In this study, a synthetic peptide representing a predicted T cell epitope on myelin oligodendrocytic basic protein (MOBP) was found to be encephalitogenic in C3H.SW mice, inducing experimental autoimmune encephalomyelitis with an abrupt onset. Two separate preliminary studies with MOBP peptides indicated that autoreactivity to MOBP occurs in MS. These data strongly suggest that MOBP is a highly relevant target in MS and further point to the complexity of antigen specificities in MS." @default.
• W1978736897 created "2016-06-24" @default.
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• W1978736897 date "2000-01-01" @default.
• W1978736897 modified "2023-10-10" @default.
• W1978736897 title "The central nervous sytem-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis (MS)" @default.
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• W1978736897 doi "https://doi.org/10.1016/s0165-5728(99)00168-x" @default.
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