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- W1978737701 abstract "Leukemic cells of patients with chronic myelogeneous leukemia (CML) are characterized by the Philadelphia (Ph) chromosome, a product of a reciprocal 9;22 translocation, t(9;22)(q34;q11) [ 1 Rowley J.D. A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. 1973; 243: 290-293 Crossref PubMed Scopus (3340) Google Scholar ]. At diagnosis and during the chronic phase of CML, the t(9;22) is usually the sole cytogenetic abnormality. Before or during the blast phase, subsequent karyotypic evolution occurs in 80% of patients, and numerous secondary chromosomal abnormalities have been reported [ 2 Rowley J.D. Testa J.R. Chromosomal abnormalities in malignant hematologic diseases. Adv Cancer Res. 1982; 36: 103-148 Crossref PubMed Scopus (127) Google Scholar ]. Among them, common abnormalities are +8, +Ph, and i(17q), and at least one of them is found in 80% of patients with disease evolution [ 2 Rowley J.D. Testa J.R. Chromosomal abnormalities in malignant hematologic diseases. Adv Cancer Res. 1982; 36: 103-148 Crossref PubMed Scopus (127) Google Scholar ]. In this report, we present a new variant translocation, (8;20)(q22;q13), in a patient with CML in extramedullary blast crisis. To our knowledge, this is the first reported case of the t(8;20) in bone marrow cells in CML." @default.
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- W1978737701 date "2000-03-01" @default.
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- W1978737701 title "New Variant Translocation (8;20)(q22;q13) in Bone Marrow Cells of Extramedullary Blast Crisis in Chronic Myelogenous Leukemia" @default.
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- W1978737701 doi "https://doi.org/10.1016/s0165-4608(99)00180-6" @default.
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