FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978744384> ?p ?o ?g. }

• W1978744384 endingPage "400" @default.
• W1978744384 startingPage "394" @default.
• W1978744384 abstract "Beta-galactosidase activity at pH 6 is associated in vitro with senescence and cellular death, but in vivo data are sparse. This study undertook firstly to map 'senescence-associated' beta-galactosidase activity (SAbetaG) at pH 6 in normal epithelia and mucosae of the upper gastrointestinal tract. As escape from senescence confers a proliferative advantage, a reduction in SAbetaG activity might be predicted in neoplasia and their precursors in vivo. This prediction was tested in metaplastic, dysplastic, and neoplastic epithelium of the upper gastrointestinal tract. Histochemical staining for SAbetaG was performed at pH 6 on cryostat sections of 350 endoscopic biopsies from sites including oesophagus, stomach, and duodenum of 46 patients: 28 with Barrett's oesophagus (two with adenocarcinoma), 15 with gastric adenocarcinoma, and three with oesophageal squamous cancer. A staining score (range 0-6) was assigned to epithelial cells in all mucosae and scores were calculated for surface (luminal), intermediate, and deep (basal) layers. The strongest SAbetaG activity was in surface luminal cells of normal duodenal mucosa (mean score 3.6+/-0.5; n=19), 'specialized' Barrett's mucosa (mean 2.2+/-0.12; n=105), and intestinal metaplasia in the stomach (mean 2.4+/-0.40; n=16). Squamous epithelium was consistently negative for SAbetaG activity. Low- and high-grade Barrett's dysplasia showed no decrease in SAbetaG activity, but reduced activity was seen in gastric and oesophageal adenocarcinomas (mean 1.24+/-0.29; n=17; p=0.012). In six gastric adenocarcinomas, there was no detectable activity. Whether SAbetaG is truly a marker of cellular senescence in vivo remains to be determined. Activity is low in mucosal proliferation compartments and increases with cellular differentiation, especially in native or metaplastic intestinal mucosae. SAbetaG activity persists in dysplastic mucosae but may show some reduction or loss in adenocarcinomas (p=0.0012). Loss of SAbetaG activity is not, therefore, an early event in glandular dysplasia-neoplasia of the upper gastrointestinal tract." @default.
• W1978744384 created "2016-06-24" @default.
• W1978744384 creator A5012881134 @default.
• W1978744384 creator A5023473749 @default.
• W1978744384 creator A5025463920 @default.
• W1978744384 creator A5078069273 @default.
• W1978744384 creator A5090188149 @default.
• W1978744384 date "2002-01-01" @default.
• W1978744384 modified "2023-09-26" @default.
• W1978744384 title "?Senescence-associated? ?-galactosidase activity in the upper gastrointestinal tract" @default.
• W1978744384 cites W1888869388 @default.
• W1978744384 cites W1968254446 @default.
• W1978744384 cites W1990025363 @default.
• W1978744384 cites W2010984881 @default.
• W1978744384 cites W2016779153 @default.
• W1978744384 cites W2061078205 @default.
• W1978744384 cites W2074768833 @default.
• W1978744384 cites W2092654917 @default.
• W1978744384 cites W2104908670 @default.
• W1978744384 cites W2133282979 @default.
• W1978744384 cites W2948387191 @default.
• W1978744384 cites W4238481641 @default.
• W1978744384 doi "https://doi.org/10.1002/path.1059" @default.
• W1978744384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11920734" @default.
• W1978744384 hasPublicationYear "2002" @default.
• W1978744384 type Work @default.
• W1978744384 sameAs 1978744384 @default.
• W1978744384 citedByCount "55" @default.
• W1978744384 countsByYear W19787443842012 @default.
• W1978744384 countsByYear W19787443842013 @default.
• W1978744384 countsByYear W19787443842014 @default.
• W1978744384 countsByYear W19787443842015 @default.
• W1978744384 countsByYear W19787443842016 @default.
• W1978744384 countsByYear W19787443842018 @default.
• W1978744384 countsByYear W19787443842019 @default.
• W1978744384 countsByYear W19787443842020 @default.
• W1978744384 countsByYear W19787443842021 @default.
• W1978744384 countsByYear W19787443842022 @default.
• W1978744384 countsByYear W19787443842023 @default.
• W1978744384 crossrefType "journal-article" @default.
• W1978744384 hasAuthorship W1978744384A5012881134 @default.
• W1978744384 hasAuthorship W1978744384A5023473749 @default.
• W1978744384 hasAuthorship W1978744384A5025463920 @default.
• W1978744384 hasAuthorship W1978744384A5078069273 @default.
• W1978744384 hasAuthorship W1978744384A5090188149 @default.
• W1978744384 hasConcept C121608353 @default.
• W1978744384 hasConcept C126322002 @default.
• W1978744384 hasConcept C142724271 @default.
• W1978744384 hasConcept C150903083 @default.
• W1978744384 hasConcept C207001950 @default.
• W1978744384 hasConcept C2775894508 @default.
• W1978744384 hasConcept C2776235491 @default.
• W1978744384 hasConcept C2776497702 @default.
• W1978744384 hasConcept C2779357193 @default.
• W1978744384 hasConcept C2779422922 @default.
• W1978744384 hasConcept C2779534503 @default.
• W1978744384 hasConcept C2780512811 @default.
• W1978744384 hasConcept C2781182431 @default.
• W1978744384 hasConcept C522857546 @default.
• W1978744384 hasConcept C529295009 @default.
• W1978744384 hasConcept C71924100 @default.
• W1978744384 hasConcept C74864618 @default.
• W1978744384 hasConcept C86803240 @default.
• W1978744384 hasConcept C90924648 @default.
• W1978744384 hasConceptScore W1978744384C121608353 @default.
• W1978744384 hasConceptScore W1978744384C126322002 @default.
• W1978744384 hasConceptScore W1978744384C142724271 @default.
• W1978744384 hasConceptScore W1978744384C150903083 @default.
• W1978744384 hasConceptScore W1978744384C207001950 @default.
• W1978744384 hasConceptScore W1978744384C2775894508 @default.
• W1978744384 hasConceptScore W1978744384C2776235491 @default.
• W1978744384 hasConceptScore W1978744384C2776497702 @default.
• W1978744384 hasConceptScore W1978744384C2779357193 @default.
• W1978744384 hasConceptScore W1978744384C2779422922 @default.
• W1978744384 hasConceptScore W1978744384C2779534503 @default.
• W1978744384 hasConceptScore W1978744384C2780512811 @default.
• W1978744384 hasConceptScore W1978744384C2781182431 @default.
• W1978744384 hasConceptScore W1978744384C522857546 @default.
• W1978744384 hasConceptScore W1978744384C529295009 @default.
• W1978744384 hasConceptScore W1978744384C71924100 @default.
• W1978744384 hasConceptScore W1978744384C74864618 @default.
• W1978744384 hasConceptScore W1978744384C86803240 @default.
• W1978744384 hasConceptScore W1978744384C90924648 @default.
• W1978744384 hasIssue "4" @default.
• W1978744384 hasLocation W19787443841 @default.
• W1978744384 hasLocation W19787443842 @default.
• W1978744384 hasOpenAccess W1978744384 @default.
• W1978744384 hasPrimaryLocation W19787443841 @default.
• W1978744384 hasRelatedWork W1167592825 @default.
• W1978744384 hasRelatedWork W1612250058 @default.
• W1978744384 hasRelatedWork W1996833759 @default.
• W1978744384 hasRelatedWork W2014627055 @default.
• W1978744384 hasRelatedWork W2054616936 @default.
• W1978744384 hasRelatedWork W2085679251 @default.
• W1978744384 hasRelatedWork W2173194892 @default.
• W1978744384 hasRelatedWork W2407045836 @default.
• W1978744384 hasRelatedWork W2410310192 @default.
• W1978744384 hasRelatedWork W3148183718 @default.

• next