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- W1978747246 abstract "Abstract General characteristics and pharmacological properties of the action of choline on the superior cervical ganglion (SCG) were studied and compared with those of dimethylphenylpiperazinium (DMPP). Chronic denervation of the SCG decreased, while preganglionic stimulation (single supramaximal and a series of intermittent submaximal) potentiated the response of this ganglion to choline. Hexamethonium blocked, while atropine considerably reduced the ganglionic effect of choline. The effect of choline on the SCG was blocked by small doses of nicotine; it was strongly reduced but not blocked by large doses. Cocaine (particularly in adrenalectomized cats), morphine and methadone considerably reduced or blocked the ganglionic effect of choline. It is concluded that there is an atropine-sensitive component in the action of choline on the SCG. The hypothesis is proposed that within the SCG there is either an intermediate type of receptor having some properties of both nicotinic and atropine-senstitive receptors or that the specificity of the latter receptors is more limited than is presently thought." @default.
- W1978747246 created "2016-06-24" @default.
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- W1978747246 date "1972-01-01" @default.
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- W1978747246 title "The action of choline on the superior cervical ganglion of the cat" @default.
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- W1978747246 doi "https://doi.org/10.1016/0014-2999(72)90273-7" @default.
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