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- W1978750436 abstract "Balancing bone resorption and formation is the quintessential component for the prevention of osteoporosis. Signals that determine the recruitment, replication, differentiation, function, and apoptosis of osteoblasts and osteoclasts direct bone remodeling and determine whether bone tissue is gained, lost, or balanced. Therefore, understanding the signaling pathways involved in the coupling process will help develop further targets for osteoporosis therapy, by blocking bone resorption or enhancing bone formation in a space- and time-dependent manner. Insulin-like growth factor type 1 (IGF-1) has long been known to play a role in bone strength. It is one of the most abundant substances in the bone matrix, circulates systemically and is secreted locally, and has a direct relationship with bone mineral density. Recent data has helped further our understanding of the direct role of IGF-1 signaling in coupling bone remodeling which will be discussed in this review. The bone marrow microenvironment plays a critical role in the fate of mesenchymal stem cells and hematopoietic stem cells and thus how IGF-1 interacts with other factors in the microenvironment are equally important. While previous clinical trials with IGF-1 administration have been unsuccessful at enhancing bone formation, advances in basic science studies have provided insight into further mechanisms that should be considered for future trials. Additional basic science studies dissecting the regulation and the function of matrix IGF-1 in modeling and remodeling will continue to provide further insight for future directions for anabolic therapies for osteoporosis." @default.
- W1978750436 created "2016-06-24" @default.
- W1978750436 creator A5004698545 @default.
- W1978750436 creator A5014357890 @default.
- W1978750436 date "2013-09-26" @default.
- W1978750436 modified "2023-10-16" @default.
- W1978750436 title "Function of matrix IGF-1 in coupling bone resorption and formation" @default.
- W1978750436 cites W1757602702 @default.
- W1978750436 cites W1965846492 @default.
- W1978750436 cites W1967502057 @default.
- W1978750436 cites W1969809139 @default.
- W1978750436 cites W1970247327 @default.
- W1978750436 cites W1971887776 @default.
- W1978750436 cites W1975784163 @default.
- W1978750436 cites W1976718154 @default.
- W1978750436 cites W1976932775 @default.
- W1978750436 cites W1977995279 @default.
- W1978750436 cites W1978676774 @default.
- W1978750436 cites W1983167741 @default.
- W1978750436 cites W1984821835 @default.
- W1978750436 cites W1985384684 @default.
- W1978750436 cites W1986568472 @default.
- W1978750436 cites W1987774165 @default.
- W1978750436 cites W1991186761 @default.
- W1978750436 cites W1991392063 @default.
- W1978750436 cites W1992460009 @default.
- W1978750436 cites W1995707695 @default.
- W1978750436 cites W1999288169 @default.
- W1978750436 cites W1999759703 @default.
- W1978750436 cites W2000706451 @default.
- W1978750436 cites W2001956022 @default.
- W1978750436 cites W2003746184 @default.
- W1978750436 cites W2004641065 @default.
- W1978750436 cites W2005284789 @default.
- W1978750436 cites W2006345660 @default.
- W1978750436 cites W2007555613 @default.
- W1978750436 cites W2008122244 @default.
- W1978750436 cites W2012640388 @default.
- W1978750436 cites W2014059985 @default.
- W1978750436 cites W2014714367 @default.
- W1978750436 cites W2015830615 @default.
- W1978750436 cites W2017442945 @default.
- W1978750436 cites W2018303697 @default.
- W1978750436 cites W2019361743 @default.
- W1978750436 cites W2020017589 @default.
- W1978750436 cites W2020480694 @default.
- W1978750436 cites W2020780182 @default.
- W1978750436 cites W2025384056 @default.
- W1978750436 cites W2028938257 @default.
- W1978750436 cites W2029509488 @default.
- W1978750436 cites W2035401388 @default.
- W1978750436 cites W2041228153 @default.
- W1978750436 cites W2041317798 @default.
- W1978750436 cites W2042108419 @default.
- W1978750436 cites W2042693437 @default.
- W1978750436 cites W2047513757 @default.
- W1978750436 cites W2048338505 @default.
- W1978750436 cites W2050966622 @default.
- W1978750436 cites W2052553384 @default.
- W1978750436 cites W2054349894 @default.
- W1978750436 cites W2056310569 @default.
- W1978750436 cites W2058462436 @default.
- W1978750436 cites W2058892394 @default.
- W1978750436 cites W2060875814 @default.
- W1978750436 cites W2063098376 @default.
- W1978750436 cites W2063220206 @default.
- W1978750436 cites W2064575648 @default.
- W1978750436 cites W2064910660 @default.
- W1978750436 cites W2065000015 @default.
- W1978750436 cites W2066314626 @default.
- W1978750436 cites W2068653028 @default.
- W1978750436 cites W2069346296 @default.
- W1978750436 cites W2069492029 @default.
- W1978750436 cites W2070835476 @default.
- W1978750436 cites W2072434201 @default.
- W1978750436 cites W2079075956 @default.
- W1978750436 cites W2080885494 @default.
- W1978750436 cites W2082664129 @default.
- W1978750436 cites W2085060879 @default.
- W1978750436 cites W2086364694 @default.
- W1978750436 cites W2086789132 @default.
- W1978750436 cites W2086824124 @default.
- W1978750436 cites W2087645454 @default.
- W1978750436 cites W2094678412 @default.
- W1978750436 cites W2096122032 @default.
- W1978750436 cites W2096842658 @default.
- W1978750436 cites W2099882033 @default.
- W1978750436 cites W2104601536 @default.
- W1978750436 cites W2107737283 @default.
- W1978750436 cites W2107941531 @default.
- W1978750436 cites W2111843196 @default.
- W1978750436 cites W2113564705 @default.
- W1978750436 cites W2113777483 @default.
- W1978750436 cites W2114157286 @default.
- W1978750436 cites W2115845714 @default.
- W1978750436 cites W2117162556 @default.
- W1978750436 cites W2117517020 @default.
- W1978750436 cites W2118793476 @default.