FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978752676> ?p ?o ?g. }

• W1978752676 endingPage "385" @default.
• W1978752676 startingPage "377" @default.
• W1978752676 abstract "The human colon cancer line Caco-2 exhibits after confluency a concomitant increase of glycogen accumulation and an enterocytic differentiation. The purpose of this work was to investigate whether forskolin (FK), an activator of adenylate cyclase, would induce a permanent glycogenolysis and, if so, whether it would result in modifications of the differentiation pattern of the cells. FK activates adenylate cyclase in Caco-2 cells with an ED50 of 7 × 10−6M. Three different treatment protocols with FK (10−5M) were applied: (1) the cells were treated during all the time in culture (20 days); (2) the treatment was started after confluency; (3) the treatment was interrupted after confluency. The presence of FK results in a permanent stimulation of cAMP accumulation (10 to 20 fold the basal values) and in a permanently reduced glycogen content (30 to 50% of the control values). The rates of glucose consumption are increased three and five fold in protocols 1 and 3 respectively. These metabolic changes are associated with morphological changes (tightening of the intercellular spaces and shortening of the brush border microvilli) and with a dual inhibition of the activities of brush border hydrolases: (a) an inhibition of the post-confluent increase of activity of sucrase, aminopeptidase N and alkaline phosphatase in the brush border enriched fraction; (b) an inhibition of the post-confluent increase of activity of sucrase in the cell homogenate. A comparison of the results obtained in each protocol shows that the morphological modifications and the decrease of the enzyme activities in the brush border fraction are regularly associated with an increased cAMP accumulation, whereas the inhibition of the differentiation of sucrase is a direct consequence of the increase in glucose consumption and decrease in glycogen stores." @default.
• W1978752676 created "2016-06-24" @default.
• W1978752676 creator A5003091280 @default.
• W1978752676 creator A5003217193 @default.
• W1978752676 creator A5015140141 @default.
• W1978752676 creator A5026490340 @default.
• W1978752676 creator A5027024773 @default.
• W1978752676 creator A5061688223 @default.
• W1978752676 creator A5069865231 @default.
• W1978752676 creator A5074672318 @default.
• W1978752676 creator A5076634867 @default.
• W1978752676 creator A5077926718 @default.
• W1978752676 date "1985-06-01" @default.
• W1978752676 modified "2023-10-16" @default.
• W1978752676 title "Enterocytic differentiation and glucose utilization in the human colon tumor cell line Caco-2: Modulation by forskolin" @default.
• W1978752676 cites W1504098071 @default.
• W1978752676 cites W1535668052 @default.
• W1978752676 cites W1775749144 @default.
• W1978752676 cites W1963958199 @default.
• W1978752676 cites W1980262453 @default.
• W1978752676 cites W2001992996 @default.
• W1978752676 cites W2009291798 @default.
• W1978752676 cites W2009708970 @default.
• W1978752676 cites W2012345358 @default.
• W1978752676 cites W2021475662 @default.
• W1978752676 cites W2029890054 @default.
• W1978752676 cites W2030834479 @default.
• W1978752676 cites W2042871417 @default.
• W1978752676 cites W2054707772 @default.
• W1978752676 cites W2059582189 @default.
• W1978752676 cites W2061689370 @default.
• W1978752676 cites W2063367991 @default.
• W1978752676 cites W2063738348 @default.
• W1978752676 cites W2065607376 @default.
• W1978752676 cites W2123929920 @default.
• W1978752676 cites W2130508879 @default.
• W1978752676 cites W2182432763 @default.
• W1978752676 cites W2404082640 @default.
• W1978752676 cites W2409411326 @default.
• W1978752676 cites W3209951468 @default.
• W1978752676 doi "https://doi.org/10.1002/jcp.1041230313" @default.
• W1978752676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2985631" @default.
• W1978752676 hasPublicationYear "1985" @default.
• W1978752676 type Work @default.
• W1978752676 sameAs 1978752676 @default.
• W1978752676 citedByCount "145" @default.
• W1978752676 countsByYear W19787526762012 @default.
• W1978752676 countsByYear W19787526762013 @default.
• W1978752676 countsByYear W19787526762014 @default.
• W1978752676 countsByYear W19787526762015 @default.
• W1978752676 countsByYear W19787526762016 @default.
• W1978752676 countsByYear W19787526762017 @default.
• W1978752676 countsByYear W19787526762018 @default.
• W1978752676 countsByYear W19787526762019 @default.
• W1978752676 countsByYear W19787526762020 @default.
• W1978752676 crossrefType "journal-article" @default.
• W1978752676 hasAuthorship W1978752676A5003091280 @default.
• W1978752676 hasAuthorship W1978752676A5003217193 @default.
• W1978752676 hasAuthorship W1978752676A5015140141 @default.
• W1978752676 hasAuthorship W1978752676A5026490340 @default.
• W1978752676 hasAuthorship W1978752676A5027024773 @default.
• W1978752676 hasAuthorship W1978752676A5061688223 @default.
• W1978752676 hasAuthorship W1978752676A5069865231 @default.
• W1978752676 hasAuthorship W1978752676A5074672318 @default.
• W1978752676 hasAuthorship W1978752676A5076634867 @default.
• W1978752676 hasAuthorship W1978752676A5077926718 @default.
• W1978752676 hasConcept C126322002 @default.
• W1978752676 hasConcept C130316041 @default.
• W1978752676 hasConcept C134018914 @default.
• W1978752676 hasConcept C192118531 @default.
• W1978752676 hasConcept C24998067 @default.
• W1978752676 hasConcept C2777499176 @default.
• W1978752676 hasConcept C2779276759 @default.
• W1978752676 hasConcept C41625074 @default.
• W1978752676 hasConcept C5426402 @default.
• W1978752676 hasConcept C55493867 @default.
• W1978752676 hasConcept C71924100 @default.
• W1978752676 hasConcept C86803240 @default.
• W1978752676 hasConcept C95444343 @default.
• W1978752676 hasConceptScore W1978752676C126322002 @default.
• W1978752676 hasConceptScore W1978752676C130316041 @default.
• W1978752676 hasConceptScore W1978752676C134018914 @default.
• W1978752676 hasConceptScore W1978752676C192118531 @default.
• W1978752676 hasConceptScore W1978752676C24998067 @default.
• W1978752676 hasConceptScore W1978752676C2777499176 @default.
• W1978752676 hasConceptScore W1978752676C2779276759 @default.
• W1978752676 hasConceptScore W1978752676C41625074 @default.
• W1978752676 hasConceptScore W1978752676C5426402 @default.
• W1978752676 hasConceptScore W1978752676C55493867 @default.
• W1978752676 hasConceptScore W1978752676C71924100 @default.
• W1978752676 hasConceptScore W1978752676C86803240 @default.
• W1978752676 hasConceptScore W1978752676C95444343 @default.
• W1978752676 hasIssue "3" @default.
• W1978752676 hasLocation W19787526761 @default.
• W1978752676 hasLocation W19787526762 @default.
• W1978752676 hasLocation W19787526763 @default.
• W1978752676 hasLocation W19787526764 @default.
• W1978752676 hasOpenAccess W1978752676 @default.

• next