FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978752684> ?p ?o ?g. }

• W1978752684 endingPage "593" @default.
• W1978752684 startingPage "585" @default.
• W1978752684 abstract "Alcohol and chronic stress exposure, especially during adolescence, can lead to an increased risk in adulthood of developing alcohol use disorders. To date, however, no study has assessed the potential long-term effects of chronic intermittent and unpredictable ethanol (EtOH) exposure in mice chronically stressed beginning in adolescence on brain function and anxiety-like behaviors in adulthood. In particular, alterations in function of the bed nucleus of the stria terminalis (BNST), a brain region heavily implicated in anxiety-related behaviors and altered plasticity following EtOH exposure, may play a key role in the pathological responses to chronic stress and EtOH. In the present study, adolescent and adult C57Bl/6J mice were exposed to a regimen of chronic social isolation and unpredictable stressors and EtOH (or air [sham]; CSI-CUS-EtOH and CSI-CUS-Sham, respectively) for 8–10 weeks. In adulthood, mice were tested for altered anxiety-like behavior (elevated plus maze [EPM] and modified social interaction [SI] test). Following behavioral testing, mice were reexposed to CSI-CUS-EtOH (and CSI-CUS-Sham for controls) for an additional 3 days. Four to six hours following the final EtOH (or air) exposure, field potential recordings of the dorsal-lateral (dl)BNST were performed. Mice first exposed during adolescence to CSI-CUS-EtOH displayed lower levels of anxiety-like behavior on the EPM compared with mice first exposed to CSI-CUS-EtOH during adulthood and control mice only exposed to CSI-CUS-Sham, regardless of age of first exposure. However, mice first exposed to CSI-CUS-EtOH during adulthood displayed lower levels of anxiety-like behavior on the SI test compared with mice first exposed during adolescence and control CSI-CUS-Sham mice. CSI-CUS-EtOH exposure, regardless of age, produced blunted expression of long-term potentiation (LTP) in the dlBNST compared with CSI-CUS-Sham mice. This study demonstrates age-dependent effects of chronic unpredictable ethanol exposure in chronically stressed mice on anxiety-like behaviors during adulthood. Further, CSI-CUS-EtOH exposure results in blunted LTP expression in the adult dlBNST." @default.
• W1978752684 created "2016-06-24" @default.
• W1978752684 creator A5016281292 @default.
• W1978752684 creator A5067751850 @default.
• W1978752684 date "2011-09-01" @default.
• W1978752684 modified "2023-10-16" @default.
• W1978752684 title "Altered anxiety-like behavior and long-term potentiation in the bed nucleus of the stria terminalis in adult mice exposed to chronic social isolation, unpredictable stress, and ethanol beginning in adolescence" @default.
• W1978752684 cites W1518512325 @default.
• W1978752684 cites W1914747759 @default.
• W1978752684 cites W1963531087 @default.
• W1978752684 cites W1966656140 @default.
• W1978752684 cites W1972345135 @default.
• W1978752684 cites W1975302052 @default.
• W1978752684 cites W1981654563 @default.
• W1978752684 cites W1983916806 @default.
• W1978752684 cites W1984346427 @default.
• W1978752684 cites W1990694352 @default.
• W1978752684 cites W1991882455 @default.
• W1978752684 cites W1997723786 @default.
• W1978752684 cites W2000031660 @default.
• W1978752684 cites W2006076158 @default.
• W1978752684 cites W2006891431 @default.
• W1978752684 cites W2010778222 @default.
• W1978752684 cites W2011379128 @default.
• W1978752684 cites W2014505101 @default.
• W1978752684 cites W2016411894 @default.
• W1978752684 cites W2018919437 @default.
• W1978752684 cites W2019741387 @default.
• W1978752684 cites W2019820140 @default.
• W1978752684 cites W2022451773 @default.
• W1978752684 cites W2032058764 @default.
• W1978752684 cites W2037954991 @default.
• W1978752684 cites W2039782265 @default.
• W1978752684 cites W2039856816 @default.
• W1978752684 cites W2042214763 @default.
• W1978752684 cites W2044220354 @default.
• W1978752684 cites W2046960533 @default.
• W1978752684 cites W2047197211 @default.
• W1978752684 cites W2049067562 @default.
• W1978752684 cites W2049614210 @default.
• W1978752684 cites W2050836998 @default.
• W1978752684 cites W2058793862 @default.
• W1978752684 cites W2059131332 @default.
• W1978752684 cites W2060984571 @default.
• W1978752684 cites W2061807141 @default.
• W1978752684 cites W2063359051 @default.
• W1978752684 cites W2065939798 @default.
• W1978752684 cites W2068999504 @default.
• W1978752684 cites W2074801302 @default.
• W1978752684 cites W2086730289 @default.
• W1978752684 cites W2090702373 @default.
• W1978752684 cites W2090779400 @default.
• W1978752684 cites W2096346638 @default.
• W1978752684 cites W2108261924 @default.
• W1978752684 cites W2111038577 @default.
• W1978752684 cites W2114524512 @default.
• W1978752684 cites W2116806046 @default.
• W1978752684 cites W2120279490 @default.
• W1978752684 cites W2123923673 @default.
• W1978752684 cites W2127655929 @default.
• W1978752684 cites W2127857578 @default.
• W1978752684 cites W2127905906 @default.
• W1978752684 cites W2138091294 @default.
• W1978752684 cites W2141050240 @default.
• W1978752684 cites W2143629083 @default.
• W1978752684 cites W2144860648 @default.
• W1978752684 cites W2146915322 @default.
• W1978752684 cites W2147352172 @default.
• W1978752684 cites W2159950826 @default.
• W1978752684 cites W2163898277 @default.
• W1978752684 cites W2165172518 @default.
• W1978752684 cites W2166054235 @default.
• W1978752684 doi "https://doi.org/10.1016/j.alcohol.2010.11.002" @default.
• W1978752684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3085602" @default.
• W1978752684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21194878" @default.
• W1978752684 hasPublicationYear "2011" @default.
• W1978752684 type Work @default.
• W1978752684 sameAs 1978752684 @default.
• W1978752684 citedByCount "34" @default.
• W1978752684 countsByYear W19787526842012 @default.
• W1978752684 countsByYear W19787526842013 @default.
• W1978752684 countsByYear W19787526842014 @default.
• W1978752684 countsByYear W19787526842015 @default.
• W1978752684 countsByYear W19787526842016 @default.
• W1978752684 countsByYear W19787526842018 @default.
• W1978752684 countsByYear W19787526842019 @default.
• W1978752684 countsByYear W19787526842020 @default.
• W1978752684 countsByYear W19787526842021 @default.
• W1978752684 countsByYear W19787526842022 @default.
• W1978752684 countsByYear W19787526842023 @default.
• W1978752684 crossrefType "journal-article" @default.
• W1978752684 hasAuthorship W1978752684A5016281292 @default.
• W1978752684 hasAuthorship W1978752684A5067751850 @default.
• W1978752684 hasBestOaLocation W19787526842 @default.
• W1978752684 hasConcept C118552586 @default.
• W1978752684 hasConcept C126322002 @default.
• W1978752684 hasConcept C134018914 @default.
• W1978752684 hasConcept C15744967 @default.

• next