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- W1978755589 abstract "The anticancer activity of cisplatin arises from its ability to bind covalently to DNA, forming primarily intrastrand cross-links to adjacent guanine residues. This work is an effort to understand the hydration effects and energetics associated with the incorporation of cisplatin into duplex DNA. A combination of spectroscopy, calorimetry, density, and ultrasonic techniques was employed to investigate the unfolding (and folding) thermodynamics of a 10-mer DNA duplex with a d(GpG) platinated cross-link and its control unplatinated duplex. The platinated duplex unfolds with a lower TM value (and lower ΔG°DSC term by 3.4 kcal/mol), which results from the compensation of an unfavorable enthalpy term with a favorable entropy term. The hydration parameters at 20 °C indicated an uptake of structural water by the platinated duplex and a release of electrostricted water by the control duplex. Relative to the control duplex, the folding of the platinated duplex at 20 °C yielded a positive differential ΔG° term (and positive differential enthalpy−entropy compensation) and a negative differential volume change. The opposite signs of the ΔΔG° and ΔΔV terms also indicated an uptake of structural water molecules by the platinated duplex. This effect is consistent with the DNA bending and unwinding induced by the cross-link and creating a hydrophobic notch at the lesion site." @default.
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- W1978755589 date "2001-10-27" @default.
- W1978755589 modified "2023-10-17" @default.
- W1978755589 title "The Incorporation of a Platinated Cross-Link into Duplex DNA Yields an Uptake of Structural Water" @default.
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- W1978755589 doi "https://doi.org/10.1021/jp0129885" @default.
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