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- W1978755969 abstract "Stable isotope labeled methadone (pentadeuteromethadone) has been used in conjunction with gas chromatography-chemical ionization mass spectrometry to study plasma disappearance rates and urinary excretion of pharmacologically active R-(−)-methadone (l-methadone) and inactive S-(+)-methadone (d-methadone) in three adult methadone maintenance patients. In all three cases, the analgesically active enantiomeric form of the drug had a significantly longer elimination half-life (t12β) when studied in a steady state than did the inactive form (t12β for active R-(−)-methadone, 51.7 to 61.8 hours; t12β for inactive S-(+)-methadone, 31.8 to 37.0 hours). The ratio of drug elimination half-lives } R-(−)-/S-(+)- ranged between 1.40 and 1.94. In the two cases so studied, slower plasma disappearance of active R-(−)-enatiomer than the inactive S-(+)-enantiomer was also observed (t12β R-(−)-, 42.8 and 52.5 hours; t12β S-(+)-, 38.3 and 41.3 hours)." @default.
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- W1978755969 date "1979-03-01" @default.
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- W1978755969 title "Stereoselective disposition of methadone in man" @default.
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- W1978755969 doi "https://doi.org/10.1016/0024-3205(79)90343-6" @default.
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