Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978758317> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1978758317 endingPage "265" @default.
- W1978758317 startingPage "260" @default.
- W1978758317 abstract "Thyroid hormone has a number of effects on cardiovascular and renal function which are shared by the atrial natriuretic peptide (ANP). We attempted to demonstrate a relationship between the two by studying the effects of thyroid hormone on the expression of the ANP gene and the secretion of its encoded protein. Thyroid hormone, when given to thyroidectomized rats, increased plasma ANP levels by approximately 2-fold in both watered and dehydrated animals. Cardiac ANP mRNA in dehydrated animals fell to 25% of that in the water-replete controls. T4 increased cardiac ANP mRNA 3-fold in dehydrated animals, but failed to alter ANP mRNA in those animals allowed free access to water. The effect of thyroid hormone appeared to take place, at least in part, at the level of the ANP-synthesizing cardiocyte. T3, at concentrations ranging from 10−10−10−8 M, increased ANP mRNA levels a maximum of 2-fold in primary cultures of neonatal cardiocytes. Both basal and T3-stimulated ANP transcripts appeared to be identical to their counterparts in the adult atria, as assessed by blot hybridization and S1 nuclease analysis. T3 (10−8 M) also effected a 2-fold increase in media ANP immunoreactivity. These data indicate that thyroid hormone increases the secretion and genetic expression of ANP in vivo and in vitro and suggests a role for the peptide as a mediator of at least some thyroid hormone effects in the cardiovascular system." @default.
- W1978758317 created "2016-06-24" @default.
- W1978758317 creator A5026915178 @default.
- W1978758317 creator A5060593720 @default.
- W1978758317 creator A5081672652 @default.
- W1978758317 date "1987-03-01" @default.
- W1978758317 modified "2023-10-15" @default.
- W1978758317 title "Thyroid Hormone Increases Rat Atrial Natriuretic Peptide Messenger Ribonucleic Acid Accumulation<i>in Vivo</i>and<i>in Vitro</i>*" @default.
- W1978758317 cites W1525917273 @default.
- W1978758317 cites W1963921468 @default.
- W1978758317 cites W1965088003 @default.
- W1978758317 cites W1977462706 @default.
- W1978758317 cites W1987790075 @default.
- W1978758317 cites W1989161728 @default.
- W1978758317 cites W2009800112 @default.
- W1978758317 cites W2019206729 @default.
- W1978758317 cites W2024494699 @default.
- W1978758317 cites W2029987769 @default.
- W1978758317 cites W2034592771 @default.
- W1978758317 cites W2034804666 @default.
- W1978758317 cites W2051590029 @default.
- W1978758317 cites W2052097767 @default.
- W1978758317 cites W2052794916 @default.
- W1978758317 cites W2065625428 @default.
- W1978758317 cites W2072245143 @default.
- W1978758317 cites W2073155183 @default.
- W1978758317 cites W2077077811 @default.
- W1978758317 cites W2082831376 @default.
- W1978758317 cites W2088986997 @default.
- W1978758317 cites W2091828650 @default.
- W1978758317 cites W2092850171 @default.
- W1978758317 cites W2125454893 @default.
- W1978758317 cites W2146649829 @default.
- W1978758317 cites W2433131917 @default.
- W1978758317 doi "https://doi.org/10.1210/mend-1-3-260" @default.
- W1978758317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2969452" @default.
- W1978758317 hasPublicationYear "1987" @default.
- W1978758317 type Work @default.
- W1978758317 sameAs 1978758317 @default.
- W1978758317 citedByCount "65" @default.
- W1978758317 countsByYear W19787583172016 @default.
- W1978758317 crossrefType "journal-article" @default.
- W1978758317 hasAuthorship W1978758317A5026915178 @default.
- W1978758317 hasAuthorship W1978758317A5060593720 @default.
- W1978758317 hasAuthorship W1978758317A5081672652 @default.
- W1978758317 hasBestOaLocation W19787583171 @default.
- W1978758317 hasConcept C104317684 @default.
- W1978758317 hasConcept C105580179 @default.
- W1978758317 hasConcept C126322002 @default.
- W1978758317 hasConcept C134018914 @default.
- W1978758317 hasConcept C150903083 @default.
- W1978758317 hasConcept C207001950 @default.
- W1978758317 hasConcept C2775915353 @default.
- W1978758317 hasConcept C2778069365 @default.
- W1978758317 hasConcept C2778198053 @default.
- W1978758317 hasConcept C3156946 @default.
- W1978758317 hasConcept C526584372 @default.
- W1978758317 hasConcept C55493867 @default.
- W1978758317 hasConcept C71315377 @default.
- W1978758317 hasConcept C71924100 @default.
- W1978758317 hasConcept C86803240 @default.
- W1978758317 hasConceptScore W1978758317C104317684 @default.
- W1978758317 hasConceptScore W1978758317C105580179 @default.
- W1978758317 hasConceptScore W1978758317C126322002 @default.
- W1978758317 hasConceptScore W1978758317C134018914 @default.
- W1978758317 hasConceptScore W1978758317C150903083 @default.
- W1978758317 hasConceptScore W1978758317C207001950 @default.
- W1978758317 hasConceptScore W1978758317C2775915353 @default.
- W1978758317 hasConceptScore W1978758317C2778069365 @default.
- W1978758317 hasConceptScore W1978758317C2778198053 @default.
- W1978758317 hasConceptScore W1978758317C3156946 @default.
- W1978758317 hasConceptScore W1978758317C526584372 @default.
- W1978758317 hasConceptScore W1978758317C55493867 @default.
- W1978758317 hasConceptScore W1978758317C71315377 @default.
- W1978758317 hasConceptScore W1978758317C71924100 @default.
- W1978758317 hasConceptScore W1978758317C86803240 @default.
- W1978758317 hasIssue "3" @default.
- W1978758317 hasLocation W19787583171 @default.
- W1978758317 hasLocation W19787583172 @default.
- W1978758317 hasOpenAccess W1978758317 @default.
- W1978758317 hasPrimaryLocation W19787583171 @default.
- W1978758317 hasRelatedWork W115736652 @default.
- W1978758317 hasRelatedWork W1874790915 @default.
- W1978758317 hasRelatedWork W1972033663 @default.
- W1978758317 hasRelatedWork W2001288055 @default.
- W1978758317 hasRelatedWork W2014120185 @default.
- W1978758317 hasRelatedWork W2110614029 @default.
- W1978758317 hasRelatedWork W2137844241 @default.
- W1978758317 hasRelatedWork W2147480685 @default.
- W1978758317 hasRelatedWork W2462397896 @default.
- W1978758317 hasRelatedWork W771333848 @default.
- W1978758317 hasVolume "1" @default.
- W1978758317 isParatext "false" @default.
- W1978758317 isRetracted "false" @default.
- W1978758317 magId "1978758317" @default.
- W1978758317 workType "article" @default.