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- W1978761729 abstract "The mitogenic effects of phytohemagglutinin (PHA), pokeweed mitogen (PWM), staphylococcal enterotoxin B (SEB) and endotoxins upon mouse spleen cells and various subpopulations were examined. The differential responses to these mitogens by cells of varying density indicate that LPS stimulates a different subpopulation from that of PHA and SEB. The subpopulation containing cells responsive to PWM seemed to differ from both of these patterns. In contrast to the effect of PHA, PWM, and SEB, thymus cells were not stimulated by LPS. LPS- and PWM-stimulated cells taken from both neonatally thymectomized and adult-thymectomized, irradiated, and bone-marrow-reconstituted animals: SEB and PHA failed to do this. It is concluded that the subpopulation responding to SEB, like that to PHA, is thymus dependent but that the two are probably not completely overlapping. That containing PWM responsive cells involves both thymus-independent and thymus-dependent cell components. The subpopulation stimulated by LPS is contained in a low density sub-population, which appears to be completely T independent." @default.
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- W1978761729 date "1974-03-01" @default.
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- W1978761729 title "Selective effects of mitogens on subpopulations of mouse lymphoid cells" @default.
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- W1978761729 doi "https://doi.org/10.1016/0008-8749(74)90009-4" @default.
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