Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978763609> ?p ?o ?g. }
- W1978763609 endingPage "2497" @default.
- W1978763609 startingPage "2488" @default.
- W1978763609 abstract "Abstract Objective Treg cells oppose autoreactive responses in several autoimmune diseases, and their frequency is reduced in systemic lupus erythematosus (SLE). In murine lupus models, treatment with anti‐DNA Ig–based peptides can expand the number of Treg cells in vivo. This study was undertaken to test the possibility that functional human Treg cells can be induced by exposure to anti‐DNA Ig–based peptides. Methods Peripheral blood mononuclear cells were isolated from 36 lupus patients and 32 healthy individuals matched for ethnicity, sex, and age. Short‐term culture experiments in the presence of several independent stimuli including anti‐DNA Ig peptides were followed by flow cytometric analysis for identification of CD4+,CD25 high T cells, cell sorting for in vitro suppression assays, and analysis of correlations between the expression of forkhead box P3 (FoxP3) and serologic and clinical characteristics of the SLE patients. Results The number of in vitro CD4+,CD25 high T cells increased after culture with anti‐DNA Ig peptides in the SLE patients, but not in the controls. The expanded CD4+,CD25 high T cells required FoxP3 for cell contact–mediated suppression of proliferation and interferon‐γ production in target CD4+,CD25− T cells. The induction of FoxP3 in SLE Treg cells occurred only in seropositive patients, and was correlated with anti‐DNA and IgG serum titers. Conclusion These results suggest a new modality to reverse the functional deficit of Treg cells in SLE patients with positive autoimmune serology, and identify a new strategy to enhance immunoregulatory T cell activity in human SLE." @default.
- W1978763609 created "2016-06-24" @default.
- W1978763609 creator A5039510130 @default.
- W1978763609 creator A5071534544 @default.
- W1978763609 creator A5072246307 @default.
- W1978763609 creator A5072870816 @default.
- W1978763609 date "2008-07-30" @default.
- W1978763609 modified "2023-10-12" @default.
- W1978763609 title "Anti-DNA Ig peptides promote Treg cell activity in systemic lupus erythematosus patients" @default.
- W1978763609 cites W1507222414 @default.
- W1978763609 cites W1530044612 @default.
- W1978763609 cites W1555334455 @default.
- W1978763609 cites W1560277370 @default.
- W1978763609 cites W1569185562 @default.
- W1978763609 cites W1636612575 @default.
- W1978763609 cites W1756044145 @default.
- W1978763609 cites W1787048953 @default.
- W1978763609 cites W1833759296 @default.
- W1978763609 cites W1991235663 @default.
- W1978763609 cites W1991882299 @default.
- W1978763609 cites W1997723053 @default.
- W1978763609 cites W2001412608 @default.
- W1978763609 cites W2002726823 @default.
- W1978763609 cites W2010720008 @default.
- W1978763609 cites W2010983216 @default.
- W1978763609 cites W2017698310 @default.
- W1978763609 cites W2021603971 @default.
- W1978763609 cites W2022833548 @default.
- W1978763609 cites W2024152763 @default.
- W1978763609 cites W2034249407 @default.
- W1978763609 cites W2037780312 @default.
- W1978763609 cites W2038154111 @default.
- W1978763609 cites W2044718209 @default.
- W1978763609 cites W2045577571 @default.
- W1978763609 cites W2064999867 @default.
- W1978763609 cites W2070527591 @default.
- W1978763609 cites W2074751624 @default.
- W1978763609 cites W2075754065 @default.
- W1978763609 cites W2076538320 @default.
- W1978763609 cites W2094727748 @default.
- W1978763609 cites W2096423439 @default.
- W1978763609 cites W2100357356 @default.
- W1978763609 cites W2102566053 @default.
- W1978763609 cites W2104048499 @default.
- W1978763609 cites W2111457140 @default.
- W1978763609 cites W2113523651 @default.
- W1978763609 cites W2120010406 @default.
- W1978763609 cites W2123249923 @default.
- W1978763609 cites W2131277118 @default.
- W1978763609 cites W2134303883 @default.
- W1978763609 cites W2146203649 @default.
- W1978763609 cites W2162819001 @default.
- W1978763609 cites W2165012155 @default.
- W1978763609 cites W2285153579 @default.
- W1978763609 doi "https://doi.org/10.1002/art.23609" @default.
- W1978763609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18668553" @default.
- W1978763609 hasPublicationYear "2008" @default.
- W1978763609 type Work @default.
- W1978763609 sameAs 1978763609 @default.
- W1978763609 citedByCount "55" @default.
- W1978763609 countsByYear W19787636092012 @default.
- W1978763609 countsByYear W19787636092013 @default.
- W1978763609 countsByYear W19787636092014 @default.
- W1978763609 countsByYear W19787636092015 @default.
- W1978763609 countsByYear W19787636092016 @default.
- W1978763609 countsByYear W19787636092017 @default.
- W1978763609 countsByYear W19787636092018 @default.
- W1978763609 countsByYear W19787636092019 @default.
- W1978763609 countsByYear W19787636092020 @default.
- W1978763609 countsByYear W19787636092021 @default.
- W1978763609 countsByYear W19787636092022 @default.
- W1978763609 crossrefType "journal-article" @default.
- W1978763609 hasAuthorship W1978763609A5039510130 @default.
- W1978763609 hasAuthorship W1978763609A5071534544 @default.
- W1978763609 hasAuthorship W1978763609A5072246307 @default.
- W1978763609 hasAuthorship W1978763609A5072870816 @default.
- W1978763609 hasConcept C126322002 @default.
- W1978763609 hasConcept C137061746 @default.
- W1978763609 hasConcept C159654299 @default.
- W1978763609 hasConcept C202751555 @default.
- W1978763609 hasConcept C203014093 @default.
- W1978763609 hasConcept C2775915377 @default.
- W1978763609 hasConcept C2776090121 @default.
- W1978763609 hasConcept C2776912625 @default.
- W1978763609 hasConcept C2778630268 @default.
- W1978763609 hasConcept C2779134260 @default.
- W1978763609 hasConcept C2779727006 @default.
- W1978763609 hasConcept C553184892 @default.
- W1978763609 hasConcept C55493867 @default.
- W1978763609 hasConcept C71924100 @default.
- W1978763609 hasConcept C79484868 @default.
- W1978763609 hasConcept C86803240 @default.
- W1978763609 hasConcept C8891405 @default.
- W1978763609 hasConceptScore W1978763609C126322002 @default.
- W1978763609 hasConceptScore W1978763609C137061746 @default.
- W1978763609 hasConceptScore W1978763609C159654299 @default.
- W1978763609 hasConceptScore W1978763609C202751555 @default.
- W1978763609 hasConceptScore W1978763609C203014093 @default.