FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978764437> ?p ?o ?g. }

• W1978764437 endingPage "83" @default.
• W1978764437 startingPage "73" @default.
• W1978764437 abstract "Adenomatous polyposis coli (APC) mutations are found in most colorectal tumours. These mutations are almost always protein-truncating, deleting both central domains that regulate Wnt signalling and C-terminal domains that interact with the cytoskeleton. The importance of Wnt dysregulation for colorectal tumourigenesis is well characterized. It is, however, unclear whether loss of C-terminal functions contributes to tumourigenesis, although this protein region has been implicated in cellular processes—including polarity, migration, mitosis, and chromosomal instability (CIN)—that have been postulated as critical for the development and progression of intestinal tumours. Since almost all APC mutations in human patients disrupt both central and C-terminal regions, we created a mouse model to test the role of the C-terminus of APC in intestinal tumourigenesis. This mouse (Apc) carries an internal deletion within Apc that dysregulates Wnt by removing the beta-catenin-binding and SAMP repeats, but leaves the C-terminus intact. We compared Apc mice with Apc animals. The latter allele represented the most commonly found human APC mutation and was identical to Apc except for absence of the entire C-terminus. Apc mice developed numerous intestinal adenomas indistinguishable in number, location, and dysplasia from those seen in Apc mice. No carcinomas were found in Apc or Apc animals. While similar disruption of the Wnt signalling pathway was observed in tumours from both mice, no evidence of differential C-terminus functions (such as cell migration, CIN, or localization of APC and EB1) was seen. We conclude that the C-terminus of APC does not influence intestinal adenoma development or progression. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd." @default.
• W1978764437 created "2016-06-24" @default.
• W1978764437 creator A5002329871 @default.
• W1978764437 creator A5021869565 @default.
• W1978764437 creator A5024727855 @default.
• W1978764437 creator A5033135177 @default.
• W1978764437 creator A5034095842 @default.
• W1978764437 creator A5036143326 @default.
• W1978764437 creator A5040598662 @default.
• W1978764437 creator A5043932592 @default.
• W1978764437 creator A5059084742 @default.
• W1978764437 creator A5061087285 @default.
• W1978764437 creator A5068660172 @default.
• W1978764437 creator A5070561840 @default.
• W1978764437 date "2011-10-18" @default.
• W1978764437 modified "2023-09-30" @default.
• W1978764437 title "The C-terminus of Apc does not influence intestinal adenoma development or progression" @default.
• W1978764437 cites W1499807572 @default.
• W1978764437 cites W1544046482 @default.
• W1978764437 cites W1546151374 @default.
• W1978764437 cites W1546492519 @default.
• W1978764437 cites W155964538 @default.
• W1978764437 cites W1666932156 @default.
• W1978764437 cites W1809606297 @default.
• W1978764437 cites W1950882148 @default.
• W1978764437 cites W1967137553 @default.
• W1978764437 cites W1967802833 @default.
• W1978764437 cites W1967921405 @default.
• W1978764437 cites W1978705545 @default.
• W1978764437 cites W1985745999 @default.
• W1978764437 cites W1990270394 @default.
• W1978764437 cites W1996302902 @default.
• W1978764437 cites W1998170462 @default.
• W1978764437 cites W2001949247 @default.
• W1978764437 cites W2002858128 @default.
• W1978764437 cites W2002897207 @default.
• W1978764437 cites W2018143234 @default.
• W1978764437 cites W2034463209 @default.
• W1978764437 cites W2049707034 @default.
• W1978764437 cites W2050862757 @default.
• W1978764437 cites W2054447190 @default.
• W1978764437 cites W2057830803 @default.
• W1978764437 cites W2068738682 @default.
• W1978764437 cites W2074584160 @default.
• W1978764437 cites W2080308138 @default.
• W1978764437 cites W2085252478 @default.
• W1978764437 cites W2093787840 @default.
• W1978764437 cites W2098475463 @default.
• W1978764437 cites W2110198156 @default.
• W1978764437 cites W2111567865 @default.
• W1978764437 cites W2113771630 @default.
• W1978764437 cites W2114252625 @default.
• W1978764437 cites W2118470180 @default.
• W1978764437 cites W2135715423 @default.
• W1978764437 cites W2139849392 @default.
• W1978764437 cites W2150195554 @default.
• W1978764437 cites W2151150093 @default.
• W1978764437 cites W2151838624 @default.
• W1978764437 cites W2159084559 @default.
• W1978764437 cites W2167290154 @default.
• W1978764437 cites W2171080110 @default.
• W1978764437 cites W2171857926 @default.
• W1978764437 cites W2171974881 @default.
• W1978764437 cites W2425892820 @default.
• W1978764437 cites W4237610859 @default.
• W1978764437 cites W65643229 @default.
• W1978764437 doi "https://doi.org/10.1002/path.2972" @default.
• W1978764437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4610063" @default.
• W1978764437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22009253" @default.
• W1978764437 hasPublicationYear "2011" @default.
• W1978764437 type Work @default.
• W1978764437 sameAs 1978764437 @default.
• W1978764437 citedByCount "17" @default.
• W1978764437 countsByYear W19787644372012 @default.
• W1978764437 countsByYear W19787644372013 @default.
• W1978764437 countsByYear W19787644372014 @default.
• W1978764437 countsByYear W19787644372015 @default.
• W1978764437 countsByYear W19787644372018 @default.
• W1978764437 countsByYear W19787644372019 @default.
• W1978764437 countsByYear W19787644372020 @default.
• W1978764437 countsByYear W19787644372023 @default.
• W1978764437 crossrefType "journal-article" @default.
• W1978764437 hasAuthorship W1978764437A5002329871 @default.
• W1978764437 hasAuthorship W1978764437A5021869565 @default.
• W1978764437 hasAuthorship W1978764437A5024727855 @default.
• W1978764437 hasAuthorship W1978764437A5033135177 @default.
• W1978764437 hasAuthorship W1978764437A5034095842 @default.
• W1978764437 hasAuthorship W1978764437A5036143326 @default.
• W1978764437 hasAuthorship W1978764437A5040598662 @default.
• W1978764437 hasAuthorship W1978764437A5043932592 @default.
• W1978764437 hasAuthorship W1978764437A5059084742 @default.
• W1978764437 hasAuthorship W1978764437A5061087285 @default.
• W1978764437 hasAuthorship W1978764437A5068660172 @default.
• W1978764437 hasAuthorship W1978764437A5070561840 @default.
• W1978764437 hasBestOaLocation W19787644372 @default.
• W1978764437 hasConcept C104317684 @default.
• W1978764437 hasConcept C121608353 @default.
• W1978764437 hasConcept C137620995 @default.

• next