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- W1978764552 abstract "Ceramide acts as second messenger in the signal transduction triggered by a variety of stress stimuli and extracellular agents. Stress response through ceramide is involved in the development of many human diseases, such as atherosclerosis, inflammation, neurodegenerative disorders, and acquired immunodeficiency syndrome. Dietary polyphenols have been reported to exert a beneficial effect on the onset and development of most of these human chronic-degenerative pathologies. However, the mechanisms underlying this beneficial effect are mostly not understood at the present. To investigate the ability of polyphenols in modulating fundamental cellular functions, we studied the effect of caffeic acid, a widespread phenolic acid largely present in human diet, in the modulation of ceramide-induced signal transduction pathway leading to apoptosis in U937 cells, in comparison with other established antioxidants of nutritional interest (N-acetylcysteine, d-alpha-tocopherol acetate and ascorbic acid). Our results indicate that caffeic acid efficiently inhibits both ceramide-induced NF-kappaB binding activity and apoptosis at micromolar concentration. Other antioxidants tested are totally ineffective in inhibiting apoptosis, although affecting NF-kappaB activation. Caffeic acid was found to inhibit protein tyrosine kinase activity, suggesting that this mechanism can be on the basis of the inhibition of apoptosis. Our results suggest that dietary caffeic acid might modulate ceramide-induced signal transduction pathway and NF-kappaB activation through either antioxidant and nonantioxidant mechanisms." @default.
- W1978764552 created "2016-06-24" @default.
- W1978764552 creator A5009773355 @default.
- W1978764552 creator A5013655343 @default.
- W1978764552 creator A5046799033 @default.
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- W1978764552 date "2001-04-01" @default.
- W1978764552 modified "2023-10-11" @default.
- W1978764552 title "Modulation of ceramide-induced NF-κB binding activity and apoptotic response by caffeic acid in U937 cells: comparison with other antioxidants" @default.
- W1978764552 cites W1491611834 @default.
- W1978764552 cites W1501063278 @default.
- W1978764552 cites W1516715449 @default.
- W1978764552 cites W1542133938 @default.
- W1978764552 cites W1564792690 @default.
- W1978764552 cites W1566441785 @default.
- W1978764552 cites W1583840873 @default.
- W1978764552 cites W1587649709 @default.
- W1978764552 cites W1607687470 @default.
- W1978764552 cites W1775749144 @default.
- W1978764552 cites W1778266683 @default.
- W1978764552 cites W1856122700 @default.
- W1978764552 cites W1938528378 @default.
- W1978764552 cites W1945253873 @default.
- W1978764552 cites W1965535129 @default.
- W1978764552 cites W1966112269 @default.
- W1978764552 cites W1970044546 @default.
- W1978764552 cites W1981281538 @default.
- W1978764552 cites W1984866351 @default.
- W1978764552 cites W1985912672 @default.
- W1978764552 cites W1988903428 @default.
- W1978764552 cites W1989411463 @default.
- W1978764552 cites W1989825919 @default.
- W1978764552 cites W1991865867 @default.
- W1978764552 cites W1995560813 @default.
- W1978764552 cites W1995894679 @default.
- W1978764552 cites W2006127629 @default.
- W1978764552 cites W2008955668 @default.
- W1978764552 cites W2010767979 @default.
- W1978764552 cites W2012563490 @default.
- W1978764552 cites W2014009420 @default.
- W1978764552 cites W2015034554 @default.
- W1978764552 cites W2017143903 @default.
- W1978764552 cites W2017729786 @default.
- W1978764552 cites W2027035900 @default.
- W1978764552 cites W2027152576 @default.
- W1978764552 cites W2029842272 @default.
- W1978764552 cites W2031643961 @default.
- W1978764552 cites W2032809973 @default.
- W1978764552 cites W2035088045 @default.
- W1978764552 cites W2035172991 @default.
- W1978764552 cites W2038013490 @default.
- W1978764552 cites W2040266344 @default.
- W1978764552 cites W2040470926 @default.
- W1978764552 cites W2042058876 @default.
- W1978764552 cites W2045850215 @default.
- W1978764552 cites W2047759180 @default.
- W1978764552 cites W2048639599 @default.
- W1978764552 cites W2049108649 @default.
- W1978764552 cites W2052170957 @default.
- W1978764552 cites W2061152334 @default.
- W1978764552 cites W2064691836 @default.
- W1978764552 cites W2073993982 @default.
- W1978764552 cites W2076429988 @default.
- W1978764552 cites W2078143363 @default.
- W1978764552 cites W2084534198 @default.
- W1978764552 cites W2086046451 @default.
- W1978764552 cites W2090483434 @default.
- W1978764552 cites W2091248991 @default.
- W1978764552 cites W2105234557 @default.
- W1978764552 cites W2118385360 @default.
- W1978764552 cites W2151892297 @default.
- W1978764552 cites W2161990266 @default.
- W1978764552 cites W2163413812 @default.
- W1978764552 cites W2169496763 @default.
- W1978764552 cites W2170036297 @default.
- W1978764552 cites W2401696497 @default.
- W1978764552 cites W2421037982 @default.
- W1978764552 cites W2483546910 @default.
- W1978764552 cites W283716313 @default.
- W1978764552 cites W4237822095 @default.
- W1978764552 cites W4293247451 @default.
- W1978764552 cites W57236300 @default.
- W1978764552 doi "https://doi.org/10.1016/s0891-5849(00)00515-3" @default.
- W1978764552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11275472" @default.
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