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- W197876714 abstract "The inner blood–retinal barrier (inner BRB) forms complex tight junctions of retinal capillary endothelial cells to prevent the free diffusion of substances between the circulating blood and the neural retina. Thus, understanding of the inner BRB transport mechanisms could provide a basis for strategies of drug delivery to the retina. Recent development of several analytical methods has succeeded in showing that the inner BRB is equipped with several membrane transporters such as GLUT1, monocarboxylate transporter 1 (MCT1), creatine transporter (CRT), xCT, L-type amino acid transporter 1 (LAT1), taurine transporter (TauT), equilibrative nucleoside transporter 2 (ENT2), organic anion transporter polypeptide 1a4 (Oatp1a4), multidrug resistance 1a (mdr1a), and ATP-binding cassette transporter G2 (Abcg2). These transporters play essential roles in supplying nutrients to the retina and are responsible for the efflux of neurotransmitter metabolites, toxins, and xenobiotics." @default.
- W197876714 created "2016-06-24" @default.
- W197876714 creator A5022660345 @default.
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- W197876714 date "2008-01-01" @default.
- W197876714 modified "2023-09-23" @default.
- W197876714 title "Molecular Mechanisms of the Inner Blood-Retinal Barrier Transporters" @default.
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- W197876714 doi "https://doi.org/10.1007/978-1-59745-375-2_8" @default.
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