FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978767862> ?p ?o ?g. }

• W1978767862 endingPage "155" @default.
• W1978767862 startingPage "143" @default.
• W1978767862 abstract "Conazoles are fungicides used in agriculture and as pharmaceuticals. In a previous toxicogenomic study of triazole-containing conazoles we found gene expression changes consistent with the alteration of the metabolism of all trans-retinoic acid (atRA), a vitamin A metabolite with cancer-preventative properties (Ward et al., Toxicol. Pathol. 2006; 34:863–78). The goals of this study were to examine effects of propiconazole, triadimefon, and myclobutanil, three triazole-containing conazoles, on the microsomal metabolism of atRA, the associated hepatic cytochrome P450 (P450) enzyme(s) involved in atRA metabolism, and their effects on hepatic atRA levels in vivo. The in vitro metabolism of atRA was quantitatively measured in liver microsomes from male CD-1 mice following four daily intraperitoneal injections of propiconazole (210 mg/kg/d), triadimefon (257 mg/kg/d) or myclobutanil (270 mg/kg/d). The formation of both 4-hydroxy-atRA and 4-oxo-atRA were significantly increased by all three conazoles. Propiconazole-induced microsomes possessed slightly greater metabolizing activities compared to myclobutanil-induced microsomes. Both propiconazole and triadimefon treatment induced greater formation of 4-hydroxy-atRA compared to myclobutanil treatment. Chemical and immuno-inhibition metabolism studies suggested that Cyp26a1, Cyp2b, and Cyp3a, but not Cyp1a1 proteins were involved in atRA metabolism. Cyp2b10/20 and Cyp3a11 genes were significantly over-expressed in the livers of both triadimefon- and propiconazole-treated mice while Cyp26a1, Cyp2c65 and Cyp1a2 genes were over-expressed in the livers of either triadimefon- or propiconazole-treated mice, and Cyp2b10/20 and Cyp3a13 genes were over-expressed in the livers of myclobutanil-treated mice. Western blot analyses indicated conazole induced-increases in Cyp2b and Cyp3a proteins. All three conazoles decreased hepatic atRA tissue levels ranging from 45–67%. The possible implications of these changes in hepatic atRA levels on cell proliferation in the mouse tumorigenesis process are discussed." @default.
• W1978767862 created "2016-06-24" @default.
• W1978767862 creator A5001681213 @default.
• W1978767862 creator A5002116781 @default.
• W1978767862 creator A5014221194 @default.
• W1978767862 creator A5017703510 @default.
• W1978767862 creator A5063606524 @default.
• W1978767862 creator A5066180307 @default.
• W1978767862 creator A5079700168 @default.
• W1978767862 creator A5082184442 @default.
• W1978767862 date "2009-01-01" @default.
• W1978767862 modified "2023-09-25" @default.
• W1978767862 title "Three conazoles increase hepatic microsomal retinoic acid metabolism and decrease mouse hepatic retinoic acid levels in vivo" @default.
• W1978767862 cites W1522988261 @default.
• W1978767862 cites W1577577364 @default.
• W1978767862 cites W1746765074 @default.
• W1978767862 cites W1857381743 @default.
• W1978767862 cites W1945474471 @default.
• W1978767862 cites W1967643634 @default.
• W1978767862 cites W1969175677 @default.
• W1978767862 cites W1982547957 @default.
• W1978767862 cites W1982649948 @default.
• W1978767862 cites W1987445229 @default.
• W1978767862 cites W1994287101 @default.
• W1978767862 cites W1996363343 @default.
• W1978767862 cites W2000502515 @default.
• W1978767862 cites W2003067274 @default.
• W1978767862 cites W2012108998 @default.
• W1978767862 cites W2015544214 @default.
• W1978767862 cites W2017724775 @default.
• W1978767862 cites W2017748328 @default.
• W1978767862 cites W2019631619 @default.
• W1978767862 cites W2024113721 @default.
• W1978767862 cites W2027876857 @default.
• W1978767862 cites W2027937833 @default.
• W1978767862 cites W2028603080 @default.
• W1978767862 cites W2034590656 @default.
• W1978767862 cites W2039836892 @default.
• W1978767862 cites W2043368734 @default.
• W1978767862 cites W2048435226 @default.
• W1978767862 cites W2049456897 @default.
• W1978767862 cites W2049810216 @default.
• W1978767862 cites W2052568266 @default.
• W1978767862 cites W2052735059 @default.
• W1978767862 cites W2067256177 @default.
• W1978767862 cites W2067961274 @default.
• W1978767862 cites W2068547598 @default.
• W1978767862 cites W2070614574 @default.
• W1978767862 cites W2071200701 @default.
• W1978767862 cites W2078889074 @default.
• W1978767862 cites W2085646040 @default.
• W1978767862 cites W2089189711 @default.
• W1978767862 cites W2091880061 @default.
• W1978767862 cites W2107277218 @default.
• W1978767862 cites W2109568316 @default.
• W1978767862 cites W2115261526 @default.
• W1978767862 cites W2118001999 @default.
• W1978767862 cites W2121588049 @default.
• W1978767862 cites W2122749842 @default.
• W1978767862 cites W2123436836 @default.
• W1978767862 cites W2128178748 @default.
• W1978767862 cites W2131614625 @default.
• W1978767862 cites W2136793746 @default.
• W1978767862 cites W2138901643 @default.
• W1978767862 cites W2140340992 @default.
• W1978767862 cites W2143146123 @default.
• W1978767862 cites W2148501124 @default.
• W1978767862 cites W2149216269 @default.
• W1978767862 cites W2156423252 @default.
• W1978767862 cites W2157428610 @default.
• W1978767862 cites W2163501641 @default.
• W1978767862 cites W2178164722 @default.
• W1978767862 cites W2340005443 @default.
• W1978767862 cites W4205429959 @default.
• W1978767862 cites W4233776919 @default.
• W1978767862 cites W4247580776 @default.
• W1978767862 cites W4248547118 @default.
• W1978767862 cites W4251201415 @default.
• W1978767862 cites W4294216491 @default.
• W1978767862 cites W4302582332 @default.
• W1978767862 doi "https://doi.org/10.1016/j.taap.2008.10.004" @default.
• W1978767862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19010342" @default.
• W1978767862 hasPublicationYear "2009" @default.
• W1978767862 type Work @default.
• W1978767862 sameAs 1978767862 @default.
• W1978767862 citedByCount "36" @default.
• W1978767862 countsByYear W19787678622012 @default.
• W1978767862 countsByYear W19787678622013 @default.
• W1978767862 countsByYear W19787678622014 @default.
• W1978767862 countsByYear W19787678622015 @default.
• W1978767862 countsByYear W19787678622016 @default.
• W1978767862 countsByYear W19787678622018 @default.
• W1978767862 countsByYear W19787678622019 @default.
• W1978767862 countsByYear W19787678622020 @default.
• W1978767862 countsByYear W19787678622021 @default.
• W1978767862 countsByYear W19787678622022 @default.
• W1978767862 crossrefType "journal-article" @default.
• W1978767862 hasAuthorship W1978767862A5001681213 @default.

• next