FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978768036> ?p ?o ?g. }

• W1978768036 endingPage "1344" @default.
• W1978768036 startingPage "1339" @default.
• W1978768036 abstract "Objectives To determine if gastric intramucosal pH is affected by hepatoenteric ischemia-reperfusion. We additionally proposed to determine if changes in gastric mucosal hydrogen ion concentration are associated with liver and lung injury following hepatoenteric ischemia-reperfusion. Finally, we hypothesized that gastric intramucosal pH is influenced by xanthine oxidase, an oxidant-generating enzyme released after hepatoenteric ischemia-reperfusion. Design Randomized, controlled, animal study. Setting University-based animal research facility. Subjects Thirty-six New Zealand white male rabbits (2 to 3 kg). Interventions Anesthetized rabbits were randomly assigned to one of four groups (n = 9 per group): a) sham-operated group; b) sham-operated group pretreated with sodium tungstate (xanthine oxidase inactivator); c) aorta occlusion group; and d) aorta occlusion group pretreated with sodium tungstate. Descending thoracic aorta occlusion was maintained for 40 mins with a 4-Fr Fogarty embolectomy catheter, followed by 2 hrs of reperfusion. Measurements and Main Results Gastric tonometry was performed after completion of the surgical preparation (30-min equilibration) and at 30, 60, 90, and 120 mins of reperfusion. Plasma alanine aminotransferase activity was determined at 120 mins of reperfusion to assess hepatic injury. Bronchoalveolar lavage of the right lung was performed after 120 mins of reperfusion, and the protein content was determined as a measure of pulmonary alveolar-capillary membrane compromise. Descending thoracic aorta occlusion resulted in a significant decrease in gastric intramucosal pH as compared with sham-operated rabbits (p < .001). The change in gastric mucosal hydrogen ion concentration was significantly associated with plasma alanine aminotransferase activity (r2 = .48, p < .01) and bronchoalveolar protein content (r2 = .51, p < .01). Xanthine oxidase inactivation significantly improved gastric intramucosal pH after aortic occlusion and reperfusion (p < .001), with a concomitant attenuation of the release of plasma alanine aminotransferase (p < .05) and accumulation of bronchoalveolar protein (p < .05) during reperfusion. Conclusions Gastric intramucosal pH was significantly decreased after hepatoenteric ischemia-reperfusion. Furthermore, an increase in gastric intramucosal hydrogen ion concentration was associated with a concomitant increase in tissue injury, a presumed harbinger of multiple organ failure. Gastric intramucosal pH values improved during reperfusion after xanthine oxidase inactivation, concomitant with attenuation of hepatic and pulmonary injury. Gastric tonometry is an important clinical tool that can provide critical insight into the pathogenesis of multiple organ injury after hepatoenteric ischemia-reperfusion. Gastric tonometry may aid in the rapid assessment of pharmacologic interventions designed to attenuate multiple organ injury in similar clinical settings (e.g., trauma, shock, major vascular surgery). (Crit Care Med 1996; 24:1339-1344)" @default.
• W1978768036 created "2016-06-24" @default.
• W1978768036 creator A5007073300 @default.
• W1978768036 creator A5040519455 @default.
• W1978768036 creator A5042356794 @default.
• W1978768036 creator A5056789095 @default.
• W1978768036 creator A5082139063 @default.
• W1978768036 date "1996-08-01" @default.
• W1978768036 modified "2023-09-24" @default.
• W1978768036 title "Gastric intramucosal pH and multiple organ injury" @default.
• W1978768036 cites W1490653169 @default.
• W1978768036 cites W1506333726 @default.
• W1978768036 cites W1583870157 @default.
• W1978768036 cites W1588405865 @default.
• W1978768036 cites W1983678535 @default.
• W1978768036 cites W1987552274 @default.
• W1978768036 cites W1995795638 @default.
• W1978768036 cites W1997335957 @default.
• W1978768036 cites W2006611906 @default.
• W1978768036 cites W2009513861 @default.
• W1978768036 cites W2017578008 @default.
• W1978768036 cites W2017812199 @default.
• W1978768036 cites W2027416526 @default.
• W1978768036 cites W2027967898 @default.
• W1978768036 cites W2033564891 @default.
• W1978768036 cites W2042672404 @default.
• W1978768036 cites W2045004453 @default.
• W1978768036 cites W2051977813 @default.
• W1978768036 cites W2053434979 @default.
• W1978768036 cites W2059702312 @default.
• W1978768036 cites W2061786705 @default.
• W1978768036 cites W2067948214 @default.
• W1978768036 cites W2091501029 @default.
• W1978768036 cites W2093436603 @default.
• W1978768036 cites W2098860687 @default.
• W1978768036 cites W2109840536 @default.
• W1978768036 cites W2125563414 @default.
• W1978768036 cites W2144889646 @default.
• W1978768036 cites W2152189486 @default.
• W1978768036 cites W2163443649 @default.
• W1978768036 cites W2165507763 @default.
• W1978768036 cites W2179193092 @default.
• W1978768036 cites W2263434320 @default.
• W1978768036 cites W2264470445 @default.
• W1978768036 cites W2399620472 @default.
• W1978768036 cites W4232534952 @default.
• W1978768036 doi "https://doi.org/10.1097/00003246-199608000-00012" @default.
• W1978768036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8706489" @default.
• W1978768036 hasPublicationYear "1996" @default.
• W1978768036 type Work @default.
• W1978768036 sameAs 1978768036 @default.
• W1978768036 citedByCount "54" @default.
• W1978768036 countsByYear W19787680362012 @default.
• W1978768036 countsByYear W19787680362014 @default.
• W1978768036 countsByYear W19787680362015 @default.
• W1978768036 countsByYear W19787680362016 @default.
• W1978768036 crossrefType "journal-article" @default.
• W1978768036 hasAuthorship W1978768036A5007073300 @default.
• W1978768036 hasAuthorship W1978768036A5040519455 @default.
• W1978768036 hasAuthorship W1978768036A5042356794 @default.
• W1978768036 hasAuthorship W1978768036A5056789095 @default.
• W1978768036 hasAuthorship W1978768036A5082139063 @default.
• W1978768036 hasConcept C126322002 @default.
• W1978768036 hasConcept C181199279 @default.
• W1978768036 hasConcept C185592680 @default.
• W1978768036 hasConcept C2777714996 @default.
• W1978768036 hasConcept C2777961210 @default.
• W1978768036 hasConcept C2778102346 @default.
• W1978768036 hasConcept C2780114680 @default.
• W1978768036 hasConcept C42219234 @default.
• W1978768036 hasConcept C541997718 @default.
• W1978768036 hasConcept C55493867 @default.
• W1978768036 hasConcept C71924100 @default.
• W1978768036 hasConceptScore W1978768036C126322002 @default.
• W1978768036 hasConceptScore W1978768036C181199279 @default.
• W1978768036 hasConceptScore W1978768036C185592680 @default.
• W1978768036 hasConceptScore W1978768036C2777714996 @default.
• W1978768036 hasConceptScore W1978768036C2777961210 @default.
• W1978768036 hasConceptScore W1978768036C2778102346 @default.
• W1978768036 hasConceptScore W1978768036C2780114680 @default.
• W1978768036 hasConceptScore W1978768036C42219234 @default.
• W1978768036 hasConceptScore W1978768036C541997718 @default.
• W1978768036 hasConceptScore W1978768036C55493867 @default.
• W1978768036 hasConceptScore W1978768036C71924100 @default.
• W1978768036 hasIssue "8" @default.
• W1978768036 hasLocation W19787680361 @default.
• W1978768036 hasLocation W19787680362 @default.
• W1978768036 hasOpenAccess W1978768036 @default.
• W1978768036 hasPrimaryLocation W19787680361 @default.
• W1978768036 hasRelatedWork W1996892136 @default.
• W1978768036 hasRelatedWork W2073328546 @default.
• W1978768036 hasRelatedWork W2370628315 @default.
• W1978768036 hasRelatedWork W2371356865 @default.
• W1978768036 hasRelatedWork W2379698561 @default.
• W1978768036 hasRelatedWork W2380643348 @default.
• W1978768036 hasRelatedWork W3029531693 @default.
• W1978768036 hasRelatedWork W3029651616 @default.
• W1978768036 hasRelatedWork W827076356 @default.

• next