Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978771427> ?p ?o ?g. }
- W1978771427 endingPage "1286" @default.
- W1978771427 startingPage "1282" @default.
- W1978771427 abstract "The efficacy of low-dose fluconazole (200 mg orally administered thrice weekly) as primary prophylaxis for cryptococcal infection was prospectively assessed in a multicenter trial involving 218 patients who were infected with human immunodeficiency virus (HIV) and who had CD4 cell counts of ≤100/mm3. The median CD4 cell count at baseline was 39/mm3; 58% of the patients had an AIDS-defining illness or infection prior to enrollment. Cryptococcal meningitis occurred in 0.4% (1) of the 218 patients. The breakthrough isolate was susceptible to fluconazole, and the fluconazole kinetic study demonstrated adequate drug absorption and serum fluconazole levels; noncompliance could not be excluded in this case. Mucocutaneous and/or esophageal candidiasis developed in 18% (40) of the patients. Noncompliance with fluconazole therapy was the only variable independently associated with breakthrough candidiasis in the study patients (P = .00002). Thus, fluconazole (200 mg thrice weekly) given to HIV-infected patients with CD4 cell counts of ≤100/mm3 was efficacious as primary prophylaxis for cryptococcosis, with notably lower costs and increased convenience for patients in comparison with daily administration of the drug." @default.
- W1978771427 created "2016-06-24" @default.
- W1978771427 creator A5013392576 @default.
- W1978771427 creator A5020920868 @default.
- W1978771427 creator A5024325837 @default.
- W1978771427 creator A5039096492 @default.
- W1978771427 creator A5049132257 @default.
- W1978771427 creator A5070513240 @default.
- W1978771427 creator A5079624082 @default.
- W1978771427 date "1996-12-01" @default.
- W1978771427 modified "2023-09-25" @default.
- W1978771427 title "Low-Dose Fluconazole as Primary Prophylaxis for Cryptococcal Infection in AIDS Patients with CD4 Cell Counts of <=100/mm3: Demonstration of Efficacy in a Prospective, Multicenter Trial" @default.
- W1978771427 cites W1509584509 @default.
- W1978771427 cites W1968157528 @default.
- W1978771427 cites W1973697574 @default.
- W1978771427 cites W1986293290 @default.
- W1978771427 cites W1998202789 @default.
- W1978771427 cites W2020426892 @default.
- W1978771427 cites W2021139571 @default.
- W1978771427 cites W2078091919 @default.
- W1978771427 cites W2079694379 @default.
- W1978771427 cites W2099567487 @default.
- W1978771427 cites W2131076784 @default.
- W1978771427 cites W2317261646 @default.
- W1978771427 cites W2339763729 @default.
- W1978771427 doi "https://doi.org/10.1093/clinids/23.6.1282" @default.
- W1978771427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8953072" @default.
- W1978771427 hasPublicationYear "1996" @default.
- W1978771427 type Work @default.
- W1978771427 sameAs 1978771427 @default.
- W1978771427 citedByCount "38" @default.
- W1978771427 countsByYear W19787714272012 @default.
- W1978771427 countsByYear W19787714272013 @default.
- W1978771427 countsByYear W19787714272014 @default.
- W1978771427 countsByYear W19787714272015 @default.
- W1978771427 countsByYear W19787714272018 @default.
- W1978771427 countsByYear W19787714272022 @default.
- W1978771427 crossrefType "journal-article" @default.
- W1978771427 hasAuthorship W1978771427A5013392576 @default.
- W1978771427 hasAuthorship W1978771427A5020920868 @default.
- W1978771427 hasAuthorship W1978771427A5024325837 @default.
- W1978771427 hasAuthorship W1978771427A5039096492 @default.
- W1978771427 hasAuthorship W1978771427A5049132257 @default.
- W1978771427 hasAuthorship W1978771427A5070513240 @default.
- W1978771427 hasAuthorship W1978771427A5079624082 @default.
- W1978771427 hasBestOaLocation W19787714271 @default.
- W1978771427 hasConcept C126322002 @default.
- W1978771427 hasConcept C141071460 @default.
- W1978771427 hasConcept C156662089 @default.
- W1978771427 hasConcept C16005928 @default.
- W1978771427 hasConcept C168563851 @default.
- W1978771427 hasConcept C188816634 @default.
- W1978771427 hasConcept C203014093 @default.
- W1978771427 hasConcept C2775965419 @default.
- W1978771427 hasConcept C2776688490 @default.
- W1978771427 hasConcept C2779134260 @default.
- W1978771427 hasConcept C2779413141 @default.
- W1978771427 hasConcept C2779548794 @default.
- W1978771427 hasConcept C2780651595 @default.
- W1978771427 hasConcept C2780727368 @default.
- W1978771427 hasConcept C2780908437 @default.
- W1978771427 hasConcept C2781005205 @default.
- W1978771427 hasConcept C2781026528 @default.
- W1978771427 hasConcept C2992435398 @default.
- W1978771427 hasConcept C3013748606 @default.
- W1978771427 hasConcept C71924100 @default.
- W1978771427 hasConcept C90924648 @default.
- W1978771427 hasConceptScore W1978771427C126322002 @default.
- W1978771427 hasConceptScore W1978771427C141071460 @default.
- W1978771427 hasConceptScore W1978771427C156662089 @default.
- W1978771427 hasConceptScore W1978771427C16005928 @default.
- W1978771427 hasConceptScore W1978771427C168563851 @default.
- W1978771427 hasConceptScore W1978771427C188816634 @default.
- W1978771427 hasConceptScore W1978771427C203014093 @default.
- W1978771427 hasConceptScore W1978771427C2775965419 @default.
- W1978771427 hasConceptScore W1978771427C2776688490 @default.
- W1978771427 hasConceptScore W1978771427C2779134260 @default.
- W1978771427 hasConceptScore W1978771427C2779413141 @default.
- W1978771427 hasConceptScore W1978771427C2779548794 @default.
- W1978771427 hasConceptScore W1978771427C2780651595 @default.
- W1978771427 hasConceptScore W1978771427C2780727368 @default.
- W1978771427 hasConceptScore W1978771427C2780908437 @default.
- W1978771427 hasConceptScore W1978771427C2781005205 @default.
- W1978771427 hasConceptScore W1978771427C2781026528 @default.
- W1978771427 hasConceptScore W1978771427C2992435398 @default.
- W1978771427 hasConceptScore W1978771427C3013748606 @default.
- W1978771427 hasConceptScore W1978771427C71924100 @default.
- W1978771427 hasConceptScore W1978771427C90924648 @default.
- W1978771427 hasIssue "6" @default.
- W1978771427 hasLocation W19787714271 @default.
- W1978771427 hasLocation W19787714272 @default.
- W1978771427 hasOpenAccess W1978771427 @default.
- W1978771427 hasPrimaryLocation W19787714271 @default.
- W1978771427 hasRelatedWork W154087051 @default.
- W1978771427 hasRelatedWork W1978771427 @default.
- W1978771427 hasRelatedWork W1983669221 @default.
- W1978771427 hasRelatedWork W2087291167 @default.
- W1978771427 hasRelatedWork W2129470678 @default.