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- W1978772535 abstract "Intracellular membrane trafficking regulates a wide variety of developmental processes, including cell and tissue morphogenesis. Here we report developmental expression of Drosophila Rab11, a small GTP-binding protein, required for both endocytic recycling and exocytosis. Rab11 is expressed in the epithelial cell types of diverse lineages at all developmental stages, beginning from the cellular blastoderm in early embryos to adult primordia and adult tissues, like the columnar epithelia lining male ejaculatory bulb. A robust expression of Rab11 is seen both in the amnioserosa and in the lateral epidermis during embryonic dorsal closure, a morphogenetic event that involves spreading and fusion of the contra-lateral sides of epidermis. Rab11 mutant embryos fail to display the characteristic morphological changes in these two epithelial tissues during dorsal closure, providing a strong basis to dissect the role of Rab11 in coordinated epithelial sheet movements. genesis 47:32–39, 2009. © 2008 Wiley-Liss, Inc." @default.
- W1978772535 created "2016-06-24" @default.
- W1978772535 creator A5001048896 @default.
- W1978772535 creator A5043846764 @default.
- W1978772535 date "2009-01-01" @default.
- W1978772535 modified "2023-09-27" @default.
- W1978772535 title "Developmental expression of Rab11, a small GTP-binding protein in<i>Drosophila</i>epithelia" @default.
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- W1978772535 doi "https://doi.org/10.1002/dvg.20441" @default.
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