Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978774893> ?p ?o ?g. }
- W1978774893 endingPage "82" @default.
- W1978774893 startingPage "75" @default.
- W1978774893 abstract "Inflammation has been considered to be related to carcinogenesis. Previously, we demonstrated that 1-hydroxyanthraquinone (1-HA), a naturally occurring carcinogen, induced severe inflammation such as ulcerative colitis in colonic mucosa. We also showed that indomethacin inhibited the tumorigenicity of 1-HA. In this study, we examined the expressions of major enzymes in arachidonic acid cascade related to inflammation in the colon mucosa of rats treated with 1-HA. After the treatment of 1% 1-HA diet, colon lesions were observed and RNA was extracted from mucosa and neoplasms. The mRNA expressions of group II phospholipase A2, cyclooxygenase-2 and 5-lipoxygenase, were examined by using a reverse transcriptase polymerase chain reaction. The expressions of phospholipase A2 and cyclooxygenase were significantly increased in non-neoplastic mucosa in rats treated with 1-HA compared with those in control rats. The expressions in the neoplasms induced by 1-HA were also increased. Phospholipase A2, especially, was much higher in the neoplasms than in non-neoplastic mucosa. However, the expression of 5-lipoxygenase showed no change in the non-neoplastic mucosa and neoplasms of rats treated with 1-HA, compared with that in control rats. These findings suggest that the inflammation induced by 1-HA may be related to the metabolites through a cyclooxygenase pathway, which indicates a prostaglandin synthesis, but not through a lipoxygenase pathway, which indicates a leukotriene synthesis in arachidonic acid cascade." @default.
- W1978774893 created "2016-06-24" @default.
- W1978774893 creator A5016864036 @default.
- W1978774893 creator A5021446171 @default.
- W1978774893 creator A5022598500 @default.
- W1978774893 creator A5023470663 @default.
- W1978774893 creator A5027623025 @default.
- W1978774893 creator A5049786044 @default.
- W1978774893 creator A5055962201 @default.
- W1978774893 creator A5063439535 @default.
- W1978774893 date "1995-10-01" @default.
- W1978774893 modified "2023-09-23" @default.
- W1978774893 title "The mRNA overexpression of inflammatory enzymes, phospholipase A2 and cyclooxygenase, in the large bowel mucosa and neoplasms of F344 rats treated with naturally occurring carcinogen, 1-hydroxyanthraquinone" @default.
- W1978774893 cites W1485442945 @default.
- W1978774893 cites W1500516885 @default.
- W1978774893 cites W1763429251 @default.
- W1978774893 cites W1890547526 @default.
- W1978774893 cites W1968838050 @default.
- W1978774893 cites W1971173327 @default.
- W1978774893 cites W1972483154 @default.
- W1978774893 cites W1975252087 @default.
- W1978774893 cites W1976304295 @default.
- W1978774893 cites W1980115898 @default.
- W1978774893 cites W2001628109 @default.
- W1978774893 cites W2002546431 @default.
- W1978774893 cites W2015871485 @default.
- W1978774893 cites W2018537723 @default.
- W1978774893 cites W2023603090 @default.
- W1978774893 cites W2024000506 @default.
- W1978774893 cites W2025723120 @default.
- W1978774893 cites W2026628125 @default.
- W1978774893 cites W2035551442 @default.
- W1978774893 cites W2045272862 @default.
- W1978774893 cites W2048095123 @default.
- W1978774893 cites W2053117633 @default.
- W1978774893 cites W2056402816 @default.
- W1978774893 cites W2072900798 @default.
- W1978774893 cites W2084647545 @default.
- W1978774893 cites W2090479278 @default.
- W1978774893 cites W2094050302 @default.
- W1978774893 cites W2114882367 @default.
- W1978774893 cites W2119060894 @default.
- W1978774893 cites W2131744664 @default.
- W1978774893 cites W2151088106 @default.
- W1978774893 cites W2167470641 @default.
- W1978774893 cites W2416960258 @default.
- W1978774893 doi "https://doi.org/10.1016/0304-3835(95)03966-z" @default.
- W1978774893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7585482" @default.
- W1978774893 hasPublicationYear "1995" @default.
- W1978774893 type Work @default.
- W1978774893 sameAs 1978774893 @default.
- W1978774893 citedByCount "20" @default.
- W1978774893 countsByYear W19787748932013 @default.
- W1978774893 countsByYear W19787748932019 @default.
- W1978774893 crossrefType "journal-article" @default.
- W1978774893 hasAuthorship W1978774893A5016864036 @default.
- W1978774893 hasAuthorship W1978774893A5021446171 @default.
- W1978774893 hasAuthorship W1978774893A5022598500 @default.
- W1978774893 hasAuthorship W1978774893A5023470663 @default.
- W1978774893 hasAuthorship W1978774893A5027623025 @default.
- W1978774893 hasAuthorship W1978774893A5049786044 @default.
- W1978774893 hasAuthorship W1978774893A5055962201 @default.
- W1978774893 hasAuthorship W1978774893A5063439535 @default.
- W1978774893 hasConcept C114246631 @default.
- W1978774893 hasConcept C126322002 @default.
- W1978774893 hasConcept C181199279 @default.
- W1978774893 hasConcept C185592680 @default.
- W1978774893 hasConcept C203014093 @default.
- W1978774893 hasConcept C2776352991 @default.
- W1978774893 hasConcept C2776551241 @default.
- W1978774893 hasConcept C2776685179 @default.
- W1978774893 hasConcept C2776914184 @default.
- W1978774893 hasConcept C2778078955 @default.
- W1978774893 hasConcept C2779689624 @default.
- W1978774893 hasConcept C2780857362 @default.
- W1978774893 hasConcept C3019368612 @default.
- W1978774893 hasConcept C55493867 @default.
- W1978774893 hasConcept C71924100 @default.
- W1978774893 hasConcept C86803240 @default.
- W1978774893 hasConcept C90342290 @default.
- W1978774893 hasConceptScore W1978774893C114246631 @default.
- W1978774893 hasConceptScore W1978774893C126322002 @default.
- W1978774893 hasConceptScore W1978774893C181199279 @default.
- W1978774893 hasConceptScore W1978774893C185592680 @default.
- W1978774893 hasConceptScore W1978774893C203014093 @default.
- W1978774893 hasConceptScore W1978774893C2776352991 @default.
- W1978774893 hasConceptScore W1978774893C2776551241 @default.
- W1978774893 hasConceptScore W1978774893C2776685179 @default.
- W1978774893 hasConceptScore W1978774893C2776914184 @default.
- W1978774893 hasConceptScore W1978774893C2778078955 @default.
- W1978774893 hasConceptScore W1978774893C2779689624 @default.
- W1978774893 hasConceptScore W1978774893C2780857362 @default.
- W1978774893 hasConceptScore W1978774893C3019368612 @default.
- W1978774893 hasConceptScore W1978774893C55493867 @default.
- W1978774893 hasConceptScore W1978774893C71924100 @default.
- W1978774893 hasConceptScore W1978774893C86803240 @default.
- W1978774893 hasConceptScore W1978774893C90342290 @default.
- W1978774893 hasFunder F4320320912 @default.