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- W1978775178 abstract "SV40 large T antigen (TAg) is a powerful oncoprotein capable of transforming a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRB) and p53 tumor suppressor proteins. In addition, TAg binds to several other cellular factors, including the transcriptional co-activators p300 and CBP, which may contribute to its transformation function. Several other features of TAg that appear to contribute to its full transformation potential are yet to be completely understood. Study of TAg therefore continues to provide new insights into the mechanism of cellular transformation." @default.
- W1978775178 created "2016-06-24" @default.
- W1978775178 creator A5081560191 @default.
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- W1978775178 date "2001-02-01" @default.
- W1978775178 modified "2023-10-18" @default.
- W1978775178 title "Cellular transformation by SV40 large T antigen: interaction with host proteins" @default.
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- W1978775178 doi "https://doi.org/10.1006/scbi.2000.0342" @default.
- W1978775178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11243895" @default.
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