FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978776973> ?p ?o ?g. }

• W1978776973 endingPage "401" @default.
• W1978776973 startingPage "401" @default.
• W1978776973 abstract "<h3>Abstract</h3> <b>Objective:</b> To assess decleration and acceleration in the disease process in the initial phase of epsilepsy in children with new onset tonic-clonic seizures. <b>Study design:</b> Hospital based follow up study. <b>Setting:</b> Two university hospitals, a general hospital, and a children9s hospital in the Netherlands. <b>Patients:</b> 204 children aged 1 month to 16 years with idiopathic or remote symptomatic, newly diagnosed, tonic-clonic seizures, of whom 123 were enrolled at time of their first ever seizure; all children were followed until the start of drug treatment (78 children), the occurrence of the fourth untreated seizure (41 children), or the end of the follow up period of two years (85 untreated children). <b>Main outcome measures:</b> Analyis of disease pattern from first ever seizure. The pattern was categorised as decelerating if the child became free of seizures despite treatment being withheld. In cases with four seizures, the pattern was categorised as decelerating if successive intervals increased or as accelerating if intervals decreased. Patterns in the remaining children were classified as uncertain. <b>Results:</b> A decelerating pattern was found in 83 of 85 children who became free of seizures without treatment. Three of the 41 children with four or more untreated seizures showed a decelerating pattern and eight an accelerating pattern. In 110 children the disease process could not be classified, mostly because drug treatment was started after the first, second, or third seizure. The proportion of children with a decelerating pattern (42%, 95% confidence interval 35% to 49%) may be a minimum estimate because of the large number of patients with an uncertain disease pattern. <b>Conclusions:</b> Though untreated epilepsy is commonly considered to be a progressive disorder with decreasing intervals between seizures, a large proportion of children with newly diagnosed, unprovoked tonic-clonic seizures have a decelerating disease process. The fear that tonic-clonic seizures commonly evolve into a progressive disease should not be used as an argument in favour of early drug treatment in children with epilepsy. <h3>Key messages</h3> Untreated epilepsy is commonly thought to be a progressive disease Early treatment, preferably after the first seizure, has been advocated In at least 42% of children with newly diagnosed tonic-clonic seizures, the disease has a decelerating pattern, with successively longer intervals between seizures The fear that tonic-clonic seizures commonly evolve into a progressive disorder should not be used as an argument in favour of early treatment of these children" @default.
• W1978776973 created "2016-06-24" @default.
• W1978776973 creator A5051053838 @default.
• W1978776973 creator A5055956402 @default.
• W1978776973 creator A5056879201 @default.
• W1978776973 creator A5058844818 @default.
• W1978776973 creator A5069524157 @default.
• W1978776973 creator A5081830569 @default.
• W1978776973 date "1997-02-08" @default.
• W1978776973 modified "2023-10-10" @default.
• W1978776973 title "Clinical course of untreated tonic-clonic seizures in childhood: prospective, hospital based study" @default.
• W1978776973 cites W1576726034 @default.
• W1978776973 cites W1590462521 @default.
• W1978776973 cites W1967331310 @default.
• W1978776973 cites W2016448757 @default.
• W1978776973 cites W2021182194 @default.
• W1978776973 cites W2024499631 @default.
• W1978776973 cites W2038868018 @default.
• W1978776973 cites W2084031564 @default.
• W1978776973 cites W2122315435 @default.
• W1978776973 cites W2142490371 @default.
• W1978776973 cites W2327844818 @default.
• W1978776973 cites W2402133369 @default.
• W1978776973 cites W2440952644 @default.
• W1978776973 cites W59511280 @default.
• W1978776973 doi "https://doi.org/10.1136/bmj.314.7078.401" @default.
• W1978776973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2125898" @default.
• W1978776973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9040384" @default.
• W1978776973 hasPublicationYear "1997" @default.
• W1978776973 type Work @default.
• W1978776973 sameAs 1978776973 @default.
• W1978776973 citedByCount "27" @default.
• W1978776973 countsByYear W19787769732019 @default.
• W1978776973 countsByYear W19787769732023 @default.
• W1978776973 crossrefType "journal-article" @default.
• W1978776973 hasAuthorship W1978776973A5051053838 @default.
• W1978776973 hasAuthorship W1978776973A5055956402 @default.
• W1978776973 hasAuthorship W1978776973A5056879201 @default.
• W1978776973 hasAuthorship W1978776973A5058844818 @default.
• W1978776973 hasAuthorship W1978776973A5069524157 @default.
• W1978776973 hasAuthorship W1978776973A5081830569 @default.
• W1978776973 hasBestOaLocation W19787769732 @default.
• W1978776973 hasConcept C118552586 @default.
• W1978776973 hasConcept C126322002 @default.
• W1978776973 hasConcept C127573956 @default.
• W1978776973 hasConcept C187212893 @default.
• W1978776973 hasConcept C188816634 @default.
• W1978776973 hasConcept C2778186239 @default.
• W1978776973 hasConcept C71924100 @default.
• W1978776973 hasConcept C986699 @default.
• W1978776973 hasConceptScore W1978776973C118552586 @default.
• W1978776973 hasConceptScore W1978776973C126322002 @default.
• W1978776973 hasConceptScore W1978776973C127573956 @default.
• W1978776973 hasConceptScore W1978776973C187212893 @default.
• W1978776973 hasConceptScore W1978776973C188816634 @default.
• W1978776973 hasConceptScore W1978776973C2778186239 @default.
• W1978776973 hasConceptScore W1978776973C71924100 @default.
• W1978776973 hasConceptScore W1978776973C986699 @default.
• W1978776973 hasIssue "7078" @default.
• W1978776973 hasLocation W19787769731 @default.
• W1978776973 hasLocation W19787769732 @default.
• W1978776973 hasLocation W19787769733 @default.
• W1978776973 hasLocation W19787769734 @default.
• W1978776973 hasLocation W19787769735 @default.
• W1978776973 hasLocation W19787769736 @default.
• W1978776973 hasLocation W19787769737 @default.
• W1978776973 hasOpenAccess W1978776973 @default.
• W1978776973 hasPrimaryLocation W19787769731 @default.
• W1978776973 hasRelatedWork W1980177115 @default.
• W1978776973 hasRelatedWork W2013957148 @default.
• W1978776973 hasRelatedWork W2079994478 @default.
• W1978776973 hasRelatedWork W2091083438 @default.
• W1978776973 hasRelatedWork W2132282183 @default.
• W1978776973 hasRelatedWork W2141597170 @default.
• W1978776973 hasRelatedWork W2163253596 @default.
• W1978776973 hasRelatedWork W2295722933 @default.
• W1978776973 hasRelatedWork W2531350361 @default.
• W1978776973 hasRelatedWork W2294699528 @default.
• W1978776973 hasVolume "314" @default.
• W1978776973 isParatext "false" @default.
• W1978776973 isRetracted "false" @default.
• W1978776973 magId "1978776973" @default.
• W1978776973 workType "article" @default.