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• W1978777639 endingPage "6483" @default.
• W1978777639 startingPage "6475" @default.
• W1978777639 abstract "Nanodiamonds are a class of carbon-based nanoparticles that are rapidly gaining attention, particularly for biomedical applications, i.e., as drug carriers, for bioimaging, or as implant coatings. Nanodiamonds have generally been considered biocompatible with a broad variety of eukaryotic cells. We show that, depending on their surface composition, nanodiamonds kill Gram-positive and -negative bacteria rapidly and efficiently. We investigated six different types of nanodiamonds exhibiting diverse oxygen-containing surface groups that were created using standard pretreatment methods for forming nanodiamond dispersions. Our experiments suggest that the antibacterial activity of nanodiamond is linked to the presence of partially oxidized and negatively charged surfaces, specifically those containing acid anhydride groups. Furthermore, proteins were found to control the bactericidal properties of nanodiamonds by covering these surface groups, which explains the previously reported biocompatibility of nanodiamonds. Our findings describe the discovery of an exciting property of partially oxidized nanodiamonds as a potent antibacterial agent." @default.
• W1978777639 created "2016-06-24" @default.
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• W1978777639 date "2014-06-05" @default.
• W1978777639 modified "2023-10-18" @default.
• W1978777639 title "Bactericidal Activity of Partially Oxidized Nanodiamonds" @default.
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• W1978777639 doi "https://doi.org/10.1021/nn502230m" @default.
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