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- W1978777932 endingPage "41" @default.
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- W1978777932 abstract "Our understanding of the functions of ceramide signaling has advanced tremendously over the past decade. In this review, we focus on the roles and regulation of neutral sphingomyelinase 2 (nSMase2), an enzyme that generates the bioactive lipid ceramide through the hydrolysis of the membrane lipid sphingomyelin. A large body of work has now implicated nSMase2 in a diverse set of cellular functions, physiological processes, and disease pathologies. We discuss different aspects of this enzyme's regulation from transcriptional, post-translational, and biochemical. Furthermore, we highlight nSMase2 involvement in cellular processes including inflammatory signaling, exosome generation, cell growth, and apoptosis, which in turn play important roles in pathologies such as cancer metastasis, Alzheimer's disease, and other organ systems disorders. Lastly, we examine avenues where targeted nSMase2-inhibition may be clinically beneficial in disease scenarios." @default.
- W1978777932 created "2016-06-24" @default.
- W1978777932 creator A5079294911 @default.
- W1978777932 creator A5089779126 @default.
- W1978777932 creator A5090422329 @default.
- W1978777932 date "2015-01-01" @default.
- W1978777932 modified "2023-10-17" @default.
- W1978777932 title "Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes" @default.
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