Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978778821> ?p ?o ?g. }
- W1978778821 endingPage "1416" @default.
- W1978778821 startingPage "1410" @default.
- W1978778821 abstract "Senescence of vascular cells contributes to the development of cardiovascular diseases and the overall aging. This study was undertaken to investigate the effects of resveratrol (Res) on amelioration of vascular cell aging and the role of SIRT1/nicotinamide adenine dinucleotide phosphate (NADPH) oxidase pathway.Adult male Wistar rats were treated with a high-fat/sucrose diet (HFS) in the presence or absence of Res for 3 months. HFS and in vitro treatment with high glucose increased the senescence cells and reactive oxygen species production in rat aorta and cultured bovine aortic endothelial cells (BAECs), respectively, which was attenuated by Res treatment. Res protected against HFS- or high-glucose-induced increase in NADPH oxidase p47phox expression and decrease in SIRT1 level. Apocynin, a NADPH oxidase inhibitor, down-regulated p47phox protein expression, but had no influence on SIRT1 protein; sirtinol, a SIRT1 inhibitor, aggravated the decrease in SIRT1 protein level and the increase in p47phox protein expression induced by high glucose.Our studies suggested that Res was able to reverse the senescence process in aorta induced by HFS in rats or induced by the exposure to high glucose in cultured BAECs. The underlying mechanism is at least SIRT1/NADPH oxidase pathway dependent." @default.
- W1978778821 created "2016-06-24" @default.
- W1978778821 creator A5001661010 @default.
- W1978778821 creator A5009183451 @default.
- W1978778821 creator A5030011300 @default.
- W1978778821 creator A5045843728 @default.
- W1978778821 creator A5053549751 @default.
- W1978778821 creator A5074962370 @default.
- W1978778821 creator A5081087398 @default.
- W1978778821 creator A5084033026 @default.
- W1978778821 creator A5089583633 @default.
- W1978778821 date "2012-11-01" @default.
- W1978778821 modified "2023-10-05" @default.
- W1978778821 title "Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms" @default.
- W1978778821 cites W1881147845 @default.
- W1978778821 cites W1964041100 @default.
- W1978778821 cites W1966405490 @default.
- W1978778821 cites W1967292684 @default.
- W1978778821 cites W1982575337 @default.
- W1978778821 cites W1984486105 @default.
- W1978778821 cites W1985308585 @default.
- W1978778821 cites W1988150327 @default.
- W1978778821 cites W1995175684 @default.
- W1978778821 cites W1999872096 @default.
- W1978778821 cites W2007842741 @default.
- W1978778821 cites W2009948917 @default.
- W1978778821 cites W2017235640 @default.
- W1978778821 cites W2028894894 @default.
- W1978778821 cites W2042793067 @default.
- W1978778821 cites W2043138902 @default.
- W1978778821 cites W2044293369 @default.
- W1978778821 cites W2060742356 @default.
- W1978778821 cites W2061023870 @default.
- W1978778821 cites W2068223162 @default.
- W1978778821 cites W2069238469 @default.
- W1978778821 cites W2073888387 @default.
- W1978778821 cites W2085128107 @default.
- W1978778821 cites W2088204476 @default.
- W1978778821 cites W2088381487 @default.
- W1978778821 cites W2097750015 @default.
- W1978778821 cites W2097948853 @default.
- W1978778821 cites W2099259500 @default.
- W1978778821 cites W2101209889 @default.
- W1978778821 cites W2102209142 @default.
- W1978778821 cites W2103649881 @default.
- W1978778821 cites W2104908670 @default.
- W1978778821 cites W2105279305 @default.
- W1978778821 cites W2111092938 @default.
- W1978778821 cites W2112708877 @default.
- W1978778821 cites W2114171855 @default.
- W1978778821 cites W2114903945 @default.
- W1978778821 cites W2118874116 @default.
- W1978778821 cites W2120494123 @default.
- W1978778821 cites W2121141378 @default.
- W1978778821 cites W2122073743 @default.
- W1978778821 cites W2122598808 @default.
- W1978778821 cites W2124561899 @default.
- W1978778821 cites W2125121177 @default.
- W1978778821 cites W2128126753 @default.
- W1978778821 cites W2132540714 @default.
- W1978778821 cites W2136256348 @default.
- W1978778821 cites W2144600435 @default.
- W1978778821 cites W2144808030 @default.
- W1978778821 cites W2147993424 @default.
- W1978778821 cites W2149321248 @default.
- W1978778821 cites W2150926180 @default.
- W1978778821 cites W2153045641 @default.
- W1978778821 cites W2154587590 @default.
- W1978778821 cites W2154949516 @default.
- W1978778821 cites W2156161891 @default.
- W1978778821 cites W2157724457 @default.
- W1978778821 cites W2160444804 @default.
- W1978778821 cites W2161585328 @default.
- W1978778821 cites W2167702935 @default.
- W1978778821 cites W2170762354 @default.
- W1978778821 cites W2171215342 @default.
- W1978778821 cites W3015544325 @default.
- W1978778821 doi "https://doi.org/10.1016/j.jnutbio.2011.08.008" @default.
- W1978778821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22284404" @default.
- W1978778821 hasPublicationYear "2012" @default.
- W1978778821 type Work @default.
- W1978778821 sameAs 1978778821 @default.
- W1978778821 citedByCount "80" @default.
- W1978778821 countsByYear W19787788212012 @default.
- W1978778821 countsByYear W19787788212013 @default.
- W1978778821 countsByYear W19787788212014 @default.
- W1978778821 countsByYear W19787788212015 @default.
- W1978778821 countsByYear W19787788212016 @default.
- W1978778821 countsByYear W19787788212017 @default.
- W1978778821 countsByYear W19787788212018 @default.
- W1978778821 countsByYear W19787788212019 @default.
- W1978778821 countsByYear W19787788212020 @default.
- W1978778821 countsByYear W19787788212021 @default.
- W1978778821 countsByYear W19787788212022 @default.
- W1978778821 countsByYear W19787788212023 @default.
- W1978778821 crossrefType "journal-article" @default.
- W1978778821 hasAuthorship W1978778821A5001661010 @default.
- W1978778821 hasAuthorship W1978778821A5009183451 @default.