FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978788478> ?p ?o ?g. }

• W1978788478 endingPage "22" @default.
• W1978788478 startingPage "16" @default.
• W1978788478 abstract "Stem cell therapy has a place for future application in the treatment of degenerative diseases. Regardless of the origin of the stem cell, when placed within a milieu of inflammatory mediator, they will show varied functions. This review focuses on human mesenchymal stem cells (MSCs) and discusses neuronal replacement using multi- and interdisciplinary approaches. We caution the enthusiasm of scientists since there is always the potential for tumor formation, even for adult stem cells. The review places RE-1 silencing transcription factor (REST) gene as central to the understanding of stem cell behavior in the microenvironment of tissue injury. REST is relevant in the development of dopaminergic and peptidergic neurons from MSCs. Premature downregulation of REST by the pro-inflammatory mediator, IL-1α, can prematurely lead to the expression of neurotransmitters, which in turn, could develop rapid crosstalk with immune cells. In-depth inter- and multi-disciplinary research will lead to rapid and safe translation of MSCs to patients. An understanding of the changes induced in MSCs by cytokines and other mediators will establish future application of MSCs and other stem cells for safe and effective treatments. This study also alludes to the potential of personalized medicine through engineering and mathematics. Keywords: Mesenchymal stem cells, neurons, cytokines, REST, cancer, aging" @default.
• W1978788478 created "2016-06-24" @default.
• W1978788478 creator A5024009298 @default.
• W1978788478 creator A5035010250 @default.
• W1978788478 creator A5037082426 @default.
• W1978788478 creator A5040438640 @default.
• W1978788478 creator A5085147005 @default.
• W1978788478 date "2009-01-01" @default.
• W1978788478 modified "2023-09-27" @default.
• W1978788478 title "Multi- and Inter-Disciplinary Science in Personalized Delivery of Stem Cells for Tissue Repair" @default.
• W1978788478 cites W105096296 @default.
• W1978788478 cites W1495998365 @default.
• W1978788478 cites W1531730510 @default.
• W1978788478 cites W1969161625 @default.
• W1978788478 cites W1970466571 @default.
• W1978788478 cites W1979799592 @default.
• W1978788478 cites W1991677760 @default.
• W1978788478 cites W1996457750 @default.
• W1978788478 cites W1998676843 @default.
• W1978788478 cites W2002253478 @default.
• W1978788478 cites W2007105351 @default.
• W1978788478 cites W2010672296 @default.
• W1978788478 cites W2019356007 @default.
• W1978788478 cites W2034729598 @default.
• W1978788478 cites W2047517092 @default.
• W1978788478 cites W2050297562 @default.
• W1978788478 cites W2054771768 @default.
• W1978788478 cites W2058347762 @default.
• W1978788478 cites W2075386523 @default.
• W1978788478 cites W2081991983 @default.
• W1978788478 cites W2089878334 @default.
• W1978788478 cites W2113452945 @default.
• W1978788478 cites W2118682325 @default.
• W1978788478 cites W2124955663 @default.
• W1978788478 cites W2144822384 @default.
• W1978788478 cites W2166534114 @default.
• W1978788478 cites W2167233362 @default.
• W1978788478 cites W2170739247 @default.
• W1978788478 doi "https://doi.org/10.2174/157488809787169075" @default.
• W1978788478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19149626" @default.
• W1978788478 hasPublicationYear "2009" @default.
• W1978788478 type Work @default.
• W1978788478 sameAs 1978788478 @default.
• W1978788478 citedByCount "6" @default.
• W1978788478 countsByYear W19787884782012 @default.
• W1978788478 countsByYear W19787884782013 @default.
• W1978788478 countsByYear W19787884782015 @default.
• W1978788478 crossrefType "journal-article" @default.
• W1978788478 hasAuthorship W1978788478A5024009298 @default.
• W1978788478 hasAuthorship W1978788478A5035010250 @default.
• W1978788478 hasAuthorship W1978788478A5037082426 @default.
• W1978788478 hasAuthorship W1978788478A5040438640 @default.
• W1978788478 hasAuthorship W1978788478A5085147005 @default.
• W1978788478 hasConcept C104317684 @default.
• W1978788478 hasConcept C120665830 @default.
• W1978788478 hasConcept C121332964 @default.
• W1978788478 hasConcept C143441281 @default.
• W1978788478 hasConcept C148738053 @default.
• W1978788478 hasConcept C169760540 @default.
• W1978788478 hasConcept C169822122 @default.
• W1978788478 hasConcept C198826908 @default.
• W1978788478 hasConcept C203014093 @default.
• W1978788478 hasConcept C20875687 @default.
• W1978788478 hasConcept C2107291 @default.
• W1978788478 hasConcept C28328180 @default.
• W1978788478 hasConcept C502942594 @default.
• W1978788478 hasConcept C54355233 @default.
• W1978788478 hasConcept C55427017 @default.
• W1978788478 hasConcept C60644358 @default.
• W1978788478 hasConcept C71924100 @default.
• W1978788478 hasConcept C86803240 @default.
• W1978788478 hasConcept C95444343 @default.
• W1978788478 hasConceptScore W1978788478C104317684 @default.
• W1978788478 hasConceptScore W1978788478C120665830 @default.
• W1978788478 hasConceptScore W1978788478C121332964 @default.
• W1978788478 hasConceptScore W1978788478C143441281 @default.
• W1978788478 hasConceptScore W1978788478C148738053 @default.
• W1978788478 hasConceptScore W1978788478C169760540 @default.
• W1978788478 hasConceptScore W1978788478C169822122 @default.
• W1978788478 hasConceptScore W1978788478C198826908 @default.
• W1978788478 hasConceptScore W1978788478C203014093 @default.
• W1978788478 hasConceptScore W1978788478C20875687 @default.
• W1978788478 hasConceptScore W1978788478C2107291 @default.
• W1978788478 hasConceptScore W1978788478C28328180 @default.
• W1978788478 hasConceptScore W1978788478C502942594 @default.
• W1978788478 hasConceptScore W1978788478C54355233 @default.
• W1978788478 hasConceptScore W1978788478C55427017 @default.
• W1978788478 hasConceptScore W1978788478C60644358 @default.
• W1978788478 hasConceptScore W1978788478C71924100 @default.
• W1978788478 hasConceptScore W1978788478C86803240 @default.
• W1978788478 hasConceptScore W1978788478C95444343 @default.
• W1978788478 hasIssue "1" @default.
• W1978788478 hasLocation W19787884781 @default.
• W1978788478 hasLocation W19787884782 @default.
• W1978788478 hasOpenAccess W1978788478 @default.
• W1978788478 hasPrimaryLocation W19787884781 @default.
• W1978788478 hasRelatedWork W1487140431 @default.
• W1978788478 hasRelatedWork W1976454147 @default.

• next