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- W1978788512 abstract "A single meal of cis-diamminedichloroplatinum (DDP) fed to virgin braconid wasps decreased drastically the number of eggs derived from oogonia. In contrast, most of the larger oocytes completed oogenesis even after a dose which shortened average lifespan to 1/3 its normal length. Temporary infecundity resulted from the destruction of the germarial cells which produced the 32 cystocytes per follicle (1 oocyte and 31 trophocytes) by mitosis. As determined by egg hatchability, oogonia were the most vulnerable cell type to DDP in the ovariole sequence. Therefore, oogonial vulnerability to DDP was demonstrated by failure to complete both gametogenesis and embryogenesis. In combination with gamma radiation, DPP reduced egg production and hatchability below the values obtained from either agent used alone. However, the decreases were moderate, as expected from additivity of effect. A difference from the results from either radiation or several types of alkylating agents appeared in the proportion of early embryonic deaths. Deaths during cleavage predominated in every daily sample of eggs treated with DDP as oocytes. Usually only the eggs laid the first 2 days after treatment are characterized by a large number of 'stage 1' deaths." @default.
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- W1978788512 date "1983-04-01" @default.
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- W1978788512 title "The pattern of damage to the oogenetic series of cells after a single feeding of cis-diamminedichloroplatinum to Habrobracon females" @default.
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- W1978788512 doi "https://doi.org/10.1016/0165-1218(83)90163-5" @default.
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