FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978788671> ?p ?o ?g. }

• W1978788671 endingPage "e51527" @default.
• W1978788671 startingPage "e51527" @default.
• W1978788671 abstract "It has been recently shown that DNA methyl transferase overexpression is correlated with unfavourable prognosis in human malignancies while methylation deregulation remains a hallmark that defines acute myeloid leukemia (AML). The oncogenic transcription factor EVI1 is involved in methylation deregulation and its overexpression plays a major role for predicting an adverse outcome. Moreover, the identification of DNMT3A mutations in AML patients has recently been described as a poor prognostic indicator. In order to clarify relationship between these key actors in methylation mechanisms and their potential impact on patient outcomes, we analysed 195 de novo AML patients for the expression of DNMT3A, 3B (and its non-catalytic variant 3B(NC)) and their correlations with the outcome and the expression of other common prognostic genetic biomarkers (EVI1, NPM1, FLT3ITD/TKD and MLL) in adult AML. The overexpression of DNMT3B/3B(NC) is (i) significantly correlated with a shorter overall survival, and (ii) inversely significantly correlated with event-free survival and DNMT3A expression level. Moreover, multivariate analysis showed that a high expression level of DNMT3B/3B(NC) is statistically a significant independent poor prognostic indicator. This study represents the first report showing that the overexpression of DNMT3B/3B(NC) is an independent predictor of poor survival in AML. Its quantification should be implemented to the genetic profile used to stratify patients for therapeutical strategies and should be useful to identify patients who may benefit from therapy based on demethylating agents." @default.
• W1978788671 created "2016-06-24" @default.
• W1978788671 creator A5007725714 @default.
• W1978788671 creator A5010797184 @default.
• W1978788671 creator A5014257321 @default.
• W1978788671 creator A5022341207 @default.
• W1978788671 creator A5028801634 @default.
• W1978788671 creator A5038427683 @default.
• W1978788671 creator A5042899914 @default.
• W1978788671 creator A5045283637 @default.
• W1978788671 creator A5045486644 @default.
• W1978788671 creator A5068343998 @default.
• W1978788671 creator A5072027146 @default.
• W1978788671 creator A5077014294 @default.
• W1978788671 creator A5077614586 @default.
• W1978788671 creator A5078817313 @default.
• W1978788671 creator A5082659815 @default.
• W1978788671 creator A5086354986 @default.
• W1978788671 date "2012-12-10" @default.
• W1978788671 modified "2023-10-04" @default.
• W1978788671 title "High DNA Methyltransferase DNMT3B Levels: A Poor Prognostic Marker in Acute Myeloid Leukemia" @default.
• W1978788671 cites W1512146889 @default.
• W1978788671 cites W1534965621 @default.
• W1978788671 cites W1808990955 @default.
• W1978788671 cites W1970963194 @default.
• W1978788671 cites W1972016428 @default.
• W1978788671 cites W1980194279 @default.
• W1978788671 cites W1981937563 @default.
• W1978788671 cites W1982541898 @default.
• W1978788671 cites W1987198309 @default.
• W1978788671 cites W2005576733 @default.
• W1978788671 cites W2010318973 @default.
• W1978788671 cites W2014337610 @default.
• W1978788671 cites W2017337160 @default.
• W1978788671 cites W2017515560 @default.
• W1978788671 cites W2018304597 @default.
• W1978788671 cites W2023094445 @default.
• W1978788671 cites W2025518169 @default.
• W1978788671 cites W2032700279 @default.
• W1978788671 cites W2036862498 @default.
• W1978788671 cites W2054111192 @default.
• W1978788671 cites W2059491580 @default.
• W1978788671 cites W2060446375 @default.
• W1978788671 cites W2066914839 @default.
• W1978788671 cites W2070541558 @default.
• W1978788671 cites W2072940754 @default.
• W1978788671 cites W2076426515 @default.
• W1978788671 cites W2078972833 @default.
• W1978788671 cites W2081712810 @default.
• W1978788671 cites W2090328782 @default.
• W1978788671 cites W2091602444 @default.
• W1978788671 cites W2103007980 @default.
• W1978788671 cites W2106194243 @default.
• W1978788671 cites W2109554035 @default.
• W1978788671 cites W2116548195 @default.
• W1978788671 cites W2117990418 @default.
• W1978788671 cites W2119674246 @default.
• W1978788671 cites W2125597344 @default.
• W1978788671 cites W2128071342 @default.
• W1978788671 cites W2128919238 @default.
• W1978788671 cites W2131072337 @default.
• W1978788671 cites W2141410747 @default.
• W1978788671 cites W2154227027 @default.
• W1978788671 cites W2155104532 @default.
• W1978788671 cites W2159507916 @default.
• W1978788671 cites W2164243576 @default.
• W1978788671 cites W4376595466 @default.
• W1978788671 doi "https://doi.org/10.1371/journal.pone.0051527" @default.
• W1978788671 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3519733" @default.
• W1978788671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23251566" @default.
• W1978788671 hasPublicationYear "2012" @default.
• W1978788671 type Work @default.
• W1978788671 sameAs 1978788671 @default.
• W1978788671 citedByCount "55" @default.
• W1978788671 countsByYear W19787886712013 @default.
• W1978788671 countsByYear W19787886712014 @default.
• W1978788671 countsByYear W19787886712015 @default.
• W1978788671 countsByYear W19787886712016 @default.
• W1978788671 countsByYear W19787886712017 @default.
• W1978788671 countsByYear W19787886712018 @default.
• W1978788671 countsByYear W19787886712019 @default.
• W1978788671 countsByYear W19787886712020 @default.
• W1978788671 countsByYear W19787886712021 @default.
• W1978788671 countsByYear W19787886712022 @default.
• W1978788671 countsByYear W19787886712023 @default.
• W1978788671 crossrefType "journal-article" @default.
• W1978788671 hasAuthorship W1978788671A5007725714 @default.
• W1978788671 hasAuthorship W1978788671A5010797184 @default.
• W1978788671 hasAuthorship W1978788671A5014257321 @default.
• W1978788671 hasAuthorship W1978788671A5022341207 @default.
• W1978788671 hasAuthorship W1978788671A5028801634 @default.
• W1978788671 hasAuthorship W1978788671A5038427683 @default.
• W1978788671 hasAuthorship W1978788671A5042899914 @default.
• W1978788671 hasAuthorship W1978788671A5045283637 @default.
• W1978788671 hasAuthorship W1978788671A5045486644 @default.
• W1978788671 hasAuthorship W1978788671A5068343998 @default.
• W1978788671 hasAuthorship W1978788671A5072027146 @default.
• W1978788671 hasAuthorship W1978788671A5077014294 @default.

• next