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• W1978789429 abstract "<h3>Objective</h3> The objective of this study was to evaluate the prognostic significance of NANOG expression in ovarian serous carcinoma. <h3>Methods</h3> The expression of NANOG was evaluated in 6 ovarian carcinoma cell lines, paclitaxel-resistant SKOV3 cells, and SKOV3 spheroid cells with semiquantitative reverse transcription–polymerase chain reaction and Western blotting. NANOG expression was also measured immunohistochemically in a tissue microarray containing ovarian tissues from 74 patients with ovarian serous carcinoma and 24 with ovarian serous cystadenoma. Each sample was scored based on signal intensity and proportion, and a score greater than 4 was considered “positive.” <h3>Results</h3> NANOG mRNA expression was variable in different ovarian cancer cell lines. The mRNA level of NANOG was increased in the paclitaxel-resistant SKOV3 cells and SKOV3 spheroid cells compared with that in the SKOV3 cells. NANOG expression was positive in 21.6% of 74 ovarian serous carcinoma tissues, but none of the ovarian serous cystadenoma tissues were positive. Positive NANOG expression was associated with residual tumor size after surgery (<i>P</i> = 0.032). The overall survival of the patients with positive NANOG expression was poorer than that of the patients with negative NANOG expression (<i>P</i> = 0.020). In patients with stage I and II disease, positive NANOG expression was independently associated with shorter overall survival compared with negative NANOG expression (40 vs 120 months, respectively; <i>P</i> = 0.031). <h3>Conclusions</h3> Positive NANOG expression is associated with poor prognosis of ovarian serous carcinoma. NANOG has potential as a predictor of survival for patients with ovarian carcinomas and may be involved in the mechanism of chemoresistance." @default.
• W1978789429 created "2016-06-24" @default.
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• W1978789429 date "2012-11-01" @default.
• W1978789429 modified "2023-09-29" @default.
• W1978789429 title "Prognostic Impact of the Cancer Stem Cell–Related Marker NANOG in Ovarian Serous Carcinoma" @default.
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• W1978789429 doi "https://doi.org/10.1097/igj.0b013e3182738307" @default.
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