FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978795226> ?p ?o ?g. }

• W1978795226 endingPage "363" @default.
• W1978795226 startingPage "359" @default.
• W1978795226 abstract "• CP-31398 suppresses excitotoxicity-induced axon degeneration . • CP-31398 suppresses excitotoxicity-induced cell body death. • CP-31398 suppresses excitotoxicity-induced mitochondrial dysfunction. Neurodegeneration causes dysfunction and degeneration of neurons and is triggered by various factors including genetic defects, free radicals, injury, and glutamate excitotoxicity . Among those, glutamate excitotoxicity is implicated in chronic disorders including AD and ALS, and in acute insults in the CNS including traumatic brain injury. Neurological disorders show hallmark morphological abnormalities such as axon degeneration and cell body death. The molecular mechanisms underlying excitotoxicity-induced neurodegeneration are complex and deciphering a molecular mechanism from one angle is beneficial to understand the process, however, still difficult to develop strategies to suppress excitotoxicity-induced degeneration due to existence of other mechanisms. Thus, directly identifying compounds that can modulate excitotoxicity-induced neurodegeneration and subsequently clarifiying the molecular mechanism is a valid approach to develop effective strategies to suppress neurodegeneration. We searched for compounds that can suppress excitotoxicity-induced neurodegeneration and found that CP-31398, a known compound that can rescue the structure and function of the tumor suppressor protein p53 mutant form and stabilize the active conformation of the p53 wild-type form, suppresses excitotoxicity-induced axon degeneration and cell body death. Moreover, CP-31398 suppresses mitochondrial dysfunction which has a strong correlation with excitotoxicity. Thus, our findings identify a compound that can serve as a novel modulator of neurodegeneration induced by glutamate excitotoxicity." @default.
• W1978795226 created "2016-06-24" @default.
• W1978795226 creator A5006718306 @default.
• W1978795226 creator A5030945685 @default.
• W1978795226 date "2013-10-01" @default.
• W1978795226 modified "2023-09-24" @default.
• W1978795226 title "A compound CP-31398 suppresses excitotoxicity-induced neurodegeneration" @default.
• W1978795226 cites W133702455 @default.
• W1978795226 cites W1508488026 @default.
• W1978795226 cites W1528196156 @default.
• W1978795226 cites W1549338235 @default.
• W1978795226 cites W1639407471 @default.
• W1978795226 cites W1920883260 @default.
• W1978795226 cites W1938878737 @default.
• W1978795226 cites W1971357333 @default.
• W1978795226 cites W1976243808 @default.
• W1978795226 cites W1981238903 @default.
• W1978795226 cites W2001781880 @default.
• W1978795226 cites W2004214625 @default.
• W1978795226 cites W2006700676 @default.
• W1978795226 cites W2008423294 @default.
• W1978795226 cites W2009297217 @default.
• W1978795226 cites W2014886834 @default.
• W1978795226 cites W2020922795 @default.
• W1978795226 cites W2021312591 @default.
• W1978795226 cites W2021927701 @default.
• W1978795226 cites W2043921726 @default.
• W1978795226 cites W2046374080 @default.
• W1978795226 cites W2055335620 @default.
• W1978795226 cites W2058769115 @default.
• W1978795226 cites W2060618478 @default.
• W1978795226 cites W2070156557 @default.
• W1978795226 cites W2070720564 @default.
• W1978795226 cites W2082879602 @default.
• W1978795226 cites W2085912953 @default.
• W1978795226 cites W2124570122 @default.
• W1978795226 cites W2146274672 @default.
• W1978795226 cites W2151585937 @default.
• W1978795226 doi "https://doi.org/10.1016/j.bbrc.2013.08.052" @default.
• W1978795226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23988450" @default.
• W1978795226 hasPublicationYear "2013" @default.
• W1978795226 type Work @default.
• W1978795226 sameAs 1978795226 @default.
• W1978795226 citedByCount "4" @default.
• W1978795226 countsByYear W19787952262014 @default.
• W1978795226 countsByYear W19787952262016 @default.
• W1978795226 countsByYear W19787952262021 @default.
• W1978795226 crossrefType "journal-article" @default.
• W1978795226 hasAuthorship W1978795226A5006718306 @default.
• W1978795226 hasAuthorship W1978795226A5030945685 @default.
• W1978795226 hasConcept C142724271 @default.
• W1978795226 hasConcept C169760540 @default.
• W1978795226 hasConcept C170493617 @default.
• W1978795226 hasConcept C178790620 @default.
• W1978795226 hasConcept C185592680 @default.
• W1978795226 hasConcept C25498285 @default.
• W1978795226 hasConcept C2776925932 @default.
• W1978795226 hasConcept C2779134260 @default.
• W1978795226 hasConcept C2779491297 @default.
• W1978795226 hasConcept C2781012912 @default.
• W1978795226 hasConcept C29730261 @default.
• W1978795226 hasConcept C55493867 @default.
• W1978795226 hasConcept C61174792 @default.
• W1978795226 hasConcept C71924100 @default.
• W1978795226 hasConcept C86803240 @default.
• W1978795226 hasConcept C95444343 @default.
• W1978795226 hasConceptScore W1978795226C142724271 @default.
• W1978795226 hasConceptScore W1978795226C169760540 @default.
• W1978795226 hasConceptScore W1978795226C170493617 @default.
• W1978795226 hasConceptScore W1978795226C178790620 @default.
• W1978795226 hasConceptScore W1978795226C185592680 @default.
• W1978795226 hasConceptScore W1978795226C25498285 @default.
• W1978795226 hasConceptScore W1978795226C2776925932 @default.
• W1978795226 hasConceptScore W1978795226C2779134260 @default.
• W1978795226 hasConceptScore W1978795226C2779491297 @default.
• W1978795226 hasConceptScore W1978795226C2781012912 @default.
• W1978795226 hasConceptScore W1978795226C29730261 @default.
• W1978795226 hasConceptScore W1978795226C55493867 @default.
• W1978795226 hasConceptScore W1978795226C61174792 @default.
• W1978795226 hasConceptScore W1978795226C71924100 @default.
• W1978795226 hasConceptScore W1978795226C86803240 @default.
• W1978795226 hasConceptScore W1978795226C95444343 @default.
• W1978795226 hasIssue "3" @default.
• W1978795226 hasLocation W19787952261 @default.
• W1978795226 hasLocation W19787952262 @default.
• W1978795226 hasOpenAccess W1978795226 @default.
• W1978795226 hasPrimaryLocation W19787952261 @default.
• W1978795226 hasRelatedWork W1965842668 @default.
• W1978795226 hasRelatedWork W2064786341 @default.
• W1978795226 hasRelatedWork W2090361924 @default.
• W1978795226 hasRelatedWork W2094849359 @default.
• W1978795226 hasRelatedWork W2146202553 @default.
• W1978795226 hasRelatedWork W2472117811 @default.
• W1978795226 hasRelatedWork W2529454941 @default.
• W1978795226 hasRelatedWork W2897638079 @default.
• W1978795226 hasRelatedWork W3024328038 @default.
• W1978795226 hasRelatedWork W3144916390 @default.
• W1978795226 hasVolume "440" @default.

• next