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• W1978796618 abstract "With the increasing use of synthetic pyrethroids (SPs), the significance of ecological safety and health risk is an emerging concern. In this study, we evaluated the chronic aquatic toxicity of cis-bifenthrin (cis-BF) in Daphnia magna and its cytotoxicity in Chinese hamster ovary (CHO) cells as well as human cervical carcinoma (Hela) cells. Chronic aquatic toxicity tests showed that cis-BF could significantly affect the reproduction of D. magna. The lowest observed effective concentration and the non-observed effective concentration of cis-BF to D. magna were 0.02 and 0.01 μg/L, respectively, and the chronic value was 0.014 μg/L. The intrinsic rate of natural increase was significantly decreased (p < 0.05) to 0.02 μg/L. The cytotoxicity assay demonstrated that cis-BF decreased cell viability in CHO and Hela cells in a concentration-and time-dependent manner. The IC50 values for Hela and CHO cells were 4.0 × 10−5 and 3.2 × 10−5 mol/L, respectively. Together, these results indicated that cis-BF induced chronic toxicity in both aquatic invertebrate animals and mammalian cells. These findings assist in understanding the impact of SPs on health and environmental safety. Considering the wide spectrum of SPs, a more comprehensive understanding of the negative effects is indispensible for planning future application and regulation of these pesticides." @default.
• W1978796618 created "2016-06-24" @default.
• W1978796618 creator A5004325176 @default.
• W1978796618 creator A5040442595 @default.
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• W1978796618 date "2009-01-01" @default.
• W1978796618 modified "2023-09-30" @default.
• W1978796618 title "Chronic toxicity and cytotoxicity of synthetic pyrethroid insecticide cis-bifenthrin" @default.
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• W1978796618 doi "https://doi.org/10.1016/s1001-0742(08)62477-8" @default.
• W1978796618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20131602" @default.
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