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- W1978798844 abstract "Abstract The ever widening use of lithium by numerous investigators and practitioners in an unusually broad array of patients presents a rich opportunity for unfortunate experiences with patients, particularly since lithium has a narrow range between therapeutic and toxic serum levels. Given a reasonably healthy and reliable patient, the risk is minimal if the dose, serum level, and clinical course is carefully monitored by a person experienced in the use of lithium, however if the situation warrants, lithium can be used in those patients who present an increased risk as a result of renal disease, cardiovascular disease, sodium depletion or other hazards. These conditions represent substantial arguments against the routine use of lithium in such patients, however, the personal, social, or physical complications of recurrence may counterbalance the risk of lithium. Extreme caution must be exercised and exceptional justification must exist before lithium is used in these hazardous situations. An assessment of the balance of hazards must be made continuously: does the risk of recurrence overweigh the risk of giving lithium under the conditions?" @default.
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- W1978798844 date "1970-05-01" @default.
- W1978798844 modified "2023-09-27" @default.
- W1978798844 title "Lithium in hazardous circumstances with one case of lithium toxicity" @default.
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- W1978798844 doi "https://doi.org/10.1016/0010-440x(70)90175-6" @default.
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