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- W1978798972 abstract "The object of this study was to assess the full developmental potential of all the blastomeres in 4-cell and 8-cell stage mouse embryos. Isolated blastomeres at these stages have limited developmental powers, and in order to follow their development into the postimplantation period a method of combining each blastomere into a chimaeric composite was devised. Preliminary experiments indicated the most favourable genetic combinations and blastomere arrangements. For the 4-cell stage embryos each individual donor blastomere was combined with genetically distinct blastomeres at the same stage to make a “Quarted” of composite embryos. The occurrence of the donor cell characters in these composites when they were recovered at the tenth day of pregnancy and at term, indicates that each 4-cell stage blastomere is totipotent and may contribute extensively to a mouse and also to the yolk sac and trophoblast. Eight-cell stage blastomeres were obtained in pairs, each pair being derived from a particular 4-cell stage blastomere. The development of the pairs were followed in chimaeric composites. Each blastomere of a pair was found to have the same range of developmental potential. This indicates a lack of segregation of morphogenetic factors and implies totipotency of the 8-cell stage blastomeres. The relevance of these results to the current theories of blastocyst differentiation is discussed." @default.
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- W1978798972 date "1977-06-01" @default.
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- W1978798972 title "Studies of the developmental potential of 4- and 8-cell stage mouse blastomeres" @default.
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- W1978798972 doi "https://doi.org/10.1002/jez.1402000307" @default.
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