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- W1978800527 abstract "Abstract Groups of 5–8 baboons were fed either a control or hypercholesterolaemic diet for 6 months. During the last 90 days, each group was given 5 i.v. injections of bovine serum albumin (BSA) at 16 day intervals or control injections of saline. Only those animals which were both hypercholesterolaemic and injected with BSA developed aortic and coronary atherosclerosis. An intravenous injection of 1 g polyunsaturated soya phosphatidyl choline (Lipostabil) thrice weekly into animals receiving the atherogenic diet and BSA, reduced the incidence and severity of aortic atherosclerosis but had no effect on plasma cholesterol, phospholipids or the fatty acid composition of the cholesterol esters and lecithin. Compared with controls, animals given the hypercholesterolaemic diet had increased aortic lipase and normal cholesterol esterase activity. Those given the same diet and Lipostabil had a normal aortic lipase and over 50% increase in cholesterol esterase activity. It is concluded that immunological injury hastens the onset of atherosclerosis produced by feeding a hypercholesterolaemic diet and that changes in aortic lipolytic enzymes may be the mechanism by which Lipostabil reduces atherosclerosis." @default.
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- W1978800527 date "1971-07-01" @default.
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- W1978800527 title "Atherosclerosis induced in hypercholesterolaemic baboons by immunological injury; and the effects of intravenous polyunsaturated phosphatidyl choline" @default.
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- W1978800527 doi "https://doi.org/10.1016/0021-9150(71)90035-9" @default.
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