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• W1978807761 abstract "No AccessJournal of UrologyClinical Urology: Original Article1 Jan 1997Urinary and Tissue Levels of Scatter Factor in Transitional Cell Carcinoma of Bladder Eliot M. Rosen, Ansamma Joseph, Liang Jin, Yan Yao, Minh-Hang T. Chau, Alexander Fuchs, Leonard Gomella, Harold Hastings, Itzhak D. Goldberg, and Gary H. Weiss Eliot M. RosenEliot M. Rosen More articles by this author , Ansamma JosephAnsamma Joseph More articles by this author , Liang JinLiang Jin More articles by this author , Yan YaoYan Yao More articles by this author , Minh-Hang T. ChauMinh-Hang T. Chau More articles by this author , Alexander FuchsAlexander Fuchs More articles by this author , Leonard GomellaLeonard Gomella More articles by this author , Harold HastingsHarold Hastings More articles by this author , Itzhak D. GoldbergItzhak D. Goldberg More articles by this author , and Gary H. WeissGary H. Weiss More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65286-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We previously reported increased titers of scatter factor in urine of 20 patients with transitional cell carcinoma of the bladder compared to noncancer and cancer control groups. Scatter factor was also found in bladder tumor extracts but the number of samples examined was too small for detailed analysis. We report a followup study of larger numbers of patients with transitional cell carcinoma and controls. Materials and Methods: The scatter factor content of urine samples and bladder tissue extracts was measured by enzyme-linked immunosorbent assay. Values were normalized per milligram creatinine or tissue protein. Statistical analysis was performed using the Mann-Whitney U test or, for multiple comparisons, the Kruskal-Wallis H test. Results: Patients with transitional cell carcinoma of the bladder (52) had higher urinary scatter factor titers than did 24 normal subjects (p <0.001) or 14 with benign prostatic hypertrophy (p <0.001), 49 with prostate cancer (p <0.001) and 13 with other genitourinary tract cancers (p <0.001). Transitional cell carcinoma cases with clinicopathological evidence of disease had greater urinary scatter factor levels than those with no evidence of disease at urine sampling (p <0.01). However, patients with transitional cell carcinomas in remission still had much greater urinary scatter factors than did normal subjects (p <0.001). In contrast, patients with active prostate cancer had urinary scatter factor levels similar to those in remission. Patients with muscle invasive or high grade transitional cell carcinomas tended to have higher urinary scatter factor levels than patients with nonmuscle invasive or low grade tumors, respectively, but the differences were not significant. Greater levels of scatter factor were present in tissue extracts of muscle invasive transitional cell carcinomas than in nonmuscle invasive tumors (p <0.001) or nontumor tissue (p <0.02). Invasion was more closely related to tissue scatter factor content than tumor grade, since high grade noninvasive transitional cell carcinomas had a scatter factor content similar to that of low grade noninvasive transitional cell carcinomas. Conclusions: These studies suggest that scatter factor may be a marker of bladder cancer, urinary scatter factor titers tend to reflect disease activity and particularly high tissue titers of scatter factor are found in muscle invasive cancers. A larger prospective study will be necessary to determine the clinical significance of elevated scatter factor titers in transitional cell carcinoma of the bladder. References 1 : Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction.. J. Cell Biol.1994; 127: 1783. 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Google Scholar Departments of Radiation Oncology, Urology, Medicine (Division of Hematology-Oncology) and Pathology, Long Island Jewish Medical Center, New Hyde Park and Department of Mathematics, Hofstra University, Hempstead, New York, and Department of Urology, Thomas Jefferson College of Medicine, Philadelphia, Pennsylvania.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byAZUMA H, TAKAHARA S, HORIE S, MUTO S, OTSUKI Y and KATSUOKA Y (2018) Induction of Apoptosis in Human Bladder Cancer Cells In Vitro and In Vivo Caused by FTY720 TreatmentJournal of Urology, VOL. 169, NO. 6, (2372-2377), Online publication date: 1-Jun-2003.MENDELSOHN J and DINNEY C (2018) THE WILLET F. WHITMORE, JR., LECTURESHIP: BLOCKADE OF EPIDERMAL GROWTH FACTOR RECEPTORS AS ANTICANCER THERAPYJournal of Urology, VOL. 165, NO. 4, (1152-1157), Online publication date: 1-Apr-2001. Volume 157Issue 1January 1997Page: 72-78 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Eliot M. Rosen More articles by this author Ansamma Joseph More articles by this author Liang Jin More articles by this author Yan Yao More articles by this author Minh-Hang T. Chau More articles by this author Alexander Fuchs More articles by this author Leonard Gomella More articles by this author Harold Hastings More articles by this author Itzhak D. Goldberg More articles by this author Gary H. Weiss More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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