FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978809975> ?p ?o ?g. }

• W1978809975 endingPage "2120" @default.
• W1978809975 startingPage "2111" @default.
• W1978809975 abstract "One of the major characteristics of tumors is their ability to evade immunosurveillance through altering the properties and functions of host stromal and/or immune cells. CCL5 has been shown to play important roles in T cell proliferation, IFN-γ, and IL-2 production, which promotes the differentiation and proliferation of Th1 cells important for immune defense against intracellular infection. In this study we found that tumor-bearing mice were more susceptible to bacterial infection and showed reduced CCL5 levels in serum during endotoxic shock. Our data further demonstrated that the soluble factors secreted by mammary gland tumor cells but not normal mammary gland epithelial cells inhibited CCL5 expression in macrophages in response to LPS, but not to TNF-α stimulation. The inhibitory effect of tumor-secreted molecules on LPS-induced CCL5 expression was regulated at the post-transcriptional level. Blocking PGE(2) synthesis by NS398 or through the use of PGE(2) receptor antagonists AH-6809 (EP2 antagonist) and AH-23848 (EP4 antagonist) completely reversed the inhibitory effect of tumor-conditioned medium (TCM) on LPS-induced CCL5 expression. Moreover, PGE(2) and the cAMP analog forskolin could mimic tumor-mediated CCL5 inhibition, and the inhibitory effects of TCM, PGE(2), and cAMP analog on LPS-induced CCL5 expression could be completely reversed by the PKA inhibitor H89. Furthermore, blocking PGE(2) synthesis in vivo led to partial recovery of CCL5 production during endotoxic shock. Taken together, our data indicate that PGE(2) secreted from breast cancer cells suppresses CCL5 secretion in LPS-activated macrophages through a cAMP/PKA signaling pathway, which may result in suppression of host immune responses against subsequent bacterial infection." @default.
• W1978809975 created "2016-06-24" @default.
• W1978809975 creator A5005706055 @default.
• W1978809975 creator A5010491128 @default.
• W1978809975 creator A5058267937 @default.
• W1978809975 date "2011-01-01" @default.
• W1978809975 modified "2023-10-04" @default.
• W1978809975 title "Tumor-secreted PGE2 Inhibits CCL5 Production in Activated Macrophages through cAMP/PKA Signaling Pathway" @default.
• W1978809975 cites W1485469970 @default.
• W1978809975 cites W1508657985 @default.
• W1978809975 cites W1527933794 @default.
• W1978809975 cites W1544385648 @default.
• W1978809975 cites W1602835962 @default.
• W1978809975 cites W1957572641 @default.
• W1978809975 cites W1967648138 @default.
• W1978809975 cites W1973836191 @default.
• W1978809975 cites W1975283105 @default.
• W1978809975 cites W1996526210 @default.
• W1978809975 cites W1996950781 @default.
• W1978809975 cites W1998310721 @default.
• W1978809975 cites W2005659566 @default.
• W1978809975 cites W2010313062 @default.
• W1978809975 cites W2014237818 @default.
• W1978809975 cites W2022041954 @default.
• W1978809975 cites W2023945291 @default.
• W1978809975 cites W2029945654 @default.
• W1978809975 cites W2029955127 @default.
• W1978809975 cites W2039820190 @default.
• W1978809975 cites W2054726092 @default.
• W1978809975 cites W2059782047 @default.
• W1978809975 cites W2061471966 @default.
• W1978809975 cites W2062592710 @default.
• W1978809975 cites W2070732038 @default.
• W1978809975 cites W2077300798 @default.
• W1978809975 cites W2088965491 @default.
• W1978809975 cites W2097699549 @default.
• W1978809975 cites W2105517511 @default.
• W1978809975 cites W2106837070 @default.
• W1978809975 cites W2127860293 @default.
• W1978809975 cites W2136770971 @default.
• W1978809975 cites W2139795951 @default.
• W1978809975 cites W2149016579 @default.
• W1978809975 cites W2160185961 @default.
• W1978809975 cites W2162328282 @default.
• W1978809975 cites W2167192576 @default.
• W1978809975 cites W2318540498 @default.
• W1978809975 cites W4211264883 @default.
• W1978809975 cites W4313377103 @default.
• W1978809975 doi "https://doi.org/10.1074/jbc.m110.154971" @default.
• W1978809975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3023508" @default.
• W1978809975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21097507" @default.
• W1978809975 hasPublicationYear "2011" @default.
• W1978809975 type Work @default.
• W1978809975 sameAs 1978809975 @default.
• W1978809975 citedByCount "51" @default.
• W1978809975 countsByYear W19788099752012 @default.
• W1978809975 countsByYear W19788099752013 @default.
• W1978809975 countsByYear W19788099752014 @default.
• W1978809975 countsByYear W19788099752015 @default.
• W1978809975 countsByYear W19788099752016 @default.
• W1978809975 countsByYear W19788099752018 @default.
• W1978809975 countsByYear W19788099752019 @default.
• W1978809975 countsByYear W19788099752020 @default.
• W1978809975 countsByYear W19788099752021 @default.
• W1978809975 countsByYear W19788099752022 @default.
• W1978809975 countsByYear W19788099752023 @default.
• W1978809975 crossrefType "journal-article" @default.
• W1978809975 hasAuthorship W1978809975A5005706055 @default.
• W1978809975 hasAuthorship W1978809975A5010491128 @default.
• W1978809975 hasAuthorship W1978809975A5058267937 @default.
• W1978809975 hasBestOaLocation W19788099751 @default.
• W1978809975 hasConcept C116484652 @default.
• W1978809975 hasConcept C134018914 @default.
• W1978809975 hasConcept C17991360 @default.
• W1978809975 hasConcept C185592680 @default.
• W1978809975 hasConcept C203014093 @default.
• W1978809975 hasConcept C2776090121 @default.
• W1978809975 hasConcept C49039625 @default.
• W1978809975 hasConcept C502942594 @default.
• W1978809975 hasConcept C79484868 @default.
• W1978809975 hasConcept C86803240 @default.
• W1978809975 hasConcept C8891405 @default.
• W1978809975 hasConcept C95444343 @default.
• W1978809975 hasConceptScore W1978809975C116484652 @default.
• W1978809975 hasConceptScore W1978809975C134018914 @default.
• W1978809975 hasConceptScore W1978809975C17991360 @default.
• W1978809975 hasConceptScore W1978809975C185592680 @default.
• W1978809975 hasConceptScore W1978809975C203014093 @default.
• W1978809975 hasConceptScore W1978809975C2776090121 @default.
• W1978809975 hasConceptScore W1978809975C49039625 @default.
• W1978809975 hasConceptScore W1978809975C502942594 @default.
• W1978809975 hasConceptScore W1978809975C79484868 @default.
• W1978809975 hasConceptScore W1978809975C86803240 @default.
• W1978809975 hasConceptScore W1978809975C8891405 @default.
• W1978809975 hasConceptScore W1978809975C95444343 @default.
• W1978809975 hasIssue "3" @default.
• W1978809975 hasLocation W19788099751 @default.
• W1978809975 hasLocation W19788099752 @default.

• next