Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978819318> ?p ?o ?g. }
- W1978819318 endingPage "8908" @default.
- W1978819318 startingPage "8898" @default.
- W1978819318 abstract "Long-term synaptic plasticity involves changes in the expression and membrane insertion of cell-surface proteins. Interestingly, the mRNAs encoding many cell-surface proteins are localized to dendrites, but whether dendritic protein synthesis is required for activity-induced surface expression of specific proteins is unknown. Herein, we used microfluidic devices to demonstrate that dendritic protein synthesis is necessary for activity-induced insertion of GluN2A-containing NMDA receptors in rat hippocampal neurons. Furthermore, visualization of activity-induced local translation of GluN2A mRNA and membrane insertion of GluN2A protein in dendrites was directly observed and shown to depend on a 3′ untranslated region cytoplasmic polyadenylation element and its associated translation complex. These findings uncover a novel mechanism for cytoplasmic polyadenylation element-mediated posttranscriptional regulation of GluN2A mRNA to control NMDA receptor surface expression during synaptic plasticity." @default.
- W1978819318 created "2016-06-24" @default.
- W1978819318 creator A5003460381 @default.
- W1978819318 creator A5017285977 @default.
- W1978819318 creator A5042061460 @default.
- W1978819318 creator A5057854320 @default.
- W1978819318 date "2013-05-15" @default.
- W1978819318 modified "2023-10-01" @default.
- W1978819318 title "Dendritic GluN2A Synthesis Mediates Activity-Induced NMDA Receptor Insertion" @default.
- W1978819318 cites W1050445 @default.
- W1978819318 cites W1502426712 @default.
- W1978819318 cites W1549120220 @default.
- W1978819318 cites W1710158115 @default.
- W1978819318 cites W1751807524 @default.
- W1978819318 cites W1968024448 @default.
- W1978819318 cites W1968311418 @default.
- W1978819318 cites W1970215478 @default.
- W1978819318 cites W1970642402 @default.
- W1978819318 cites W1979496428 @default.
- W1978819318 cites W1981085577 @default.
- W1978819318 cites W1985241009 @default.
- W1978819318 cites W1986120363 @default.
- W1978819318 cites W1990888591 @default.
- W1978819318 cites W1994217011 @default.
- W1978819318 cites W1997539008 @default.
- W1978819318 cites W1998254077 @default.
- W1978819318 cites W2002295532 @default.
- W1978819318 cites W2011599467 @default.
- W1978819318 cites W2016032579 @default.
- W1978819318 cites W2024757567 @default.
- W1978819318 cites W2025011598 @default.
- W1978819318 cites W2027436298 @default.
- W1978819318 cites W2027699509 @default.
- W1978819318 cites W2029277937 @default.
- W1978819318 cites W2031779883 @default.
- W1978819318 cites W2035082265 @default.
- W1978819318 cites W2036564583 @default.
- W1978819318 cites W2037852973 @default.
- W1978819318 cites W2039005185 @default.
- W1978819318 cites W2054855377 @default.
- W1978819318 cites W2057658086 @default.
- W1978819318 cites W2058281248 @default.
- W1978819318 cites W2059117412 @default.
- W1978819318 cites W2066358338 @default.
- W1978819318 cites W2072282121 @default.
- W1978819318 cites W2074079341 @default.
- W1978819318 cites W2087824537 @default.
- W1978819318 cites W2091597912 @default.
- W1978819318 cites W2095512479 @default.
- W1978819318 cites W2106776289 @default.
- W1978819318 cites W2109851824 @default.
- W1978819318 cites W2118654091 @default.
- W1978819318 cites W2129761500 @default.
- W1978819318 cites W2135004571 @default.
- W1978819318 cites W2141545756 @default.
- W1978819318 cites W2144489822 @default.
- W1978819318 cites W2145242428 @default.
- W1978819318 cites W2152402650 @default.
- W1978819318 cites W2158323020 @default.
- W1978819318 cites W2161352090 @default.
- W1978819318 cites W2165676162 @default.
- W1978819318 cites W2166843521 @default.
- W1978819318 cites W2169309596 @default.
- W1978819318 cites W4313025241 @default.
- W1978819318 doi "https://doi.org/10.1523/jneurosci.0289-13.2013" @default.
- W1978819318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3684268" @default.
- W1978819318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23678131" @default.
- W1978819318 hasPublicationYear "2013" @default.
- W1978819318 type Work @default.
- W1978819318 sameAs 1978819318 @default.
- W1978819318 citedByCount "42" @default.
- W1978819318 countsByYear W19788193182013 @default.
- W1978819318 countsByYear W19788193182014 @default.
- W1978819318 countsByYear W19788193182015 @default.
- W1978819318 countsByYear W19788193182016 @default.
- W1978819318 countsByYear W19788193182017 @default.
- W1978819318 countsByYear W19788193182018 @default.
- W1978819318 countsByYear W19788193182019 @default.
- W1978819318 countsByYear W19788193182020 @default.
- W1978819318 countsByYear W19788193182021 @default.
- W1978819318 crossrefType "journal-article" @default.
- W1978819318 hasAuthorship W1978819318A5003460381 @default.
- W1978819318 hasAuthorship W1978819318A5017285977 @default.
- W1978819318 hasAuthorship W1978819318A5042061460 @default.
- W1978819318 hasAuthorship W1978819318A5057854320 @default.
- W1978819318 hasBestOaLocation W19788193181 @default.
- W1978819318 hasConcept C104317684 @default.
- W1978819318 hasConcept C105580179 @default.
- W1978819318 hasConcept C142575336 @default.
- W1978819318 hasConcept C148762608 @default.
- W1978819318 hasConcept C149364088 @default.
- W1978819318 hasConcept C169760540 @default.
- W1978819318 hasConcept C170493617 @default.
- W1978819318 hasConcept C185592680 @default.
- W1978819318 hasConcept C25274449 @default.
- W1978819318 hasConcept C55493867 @default.
- W1978819318 hasConcept C67018056 @default.
- W1978819318 hasConcept C86803240 @default.