Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978830897> ?p ?o ?g. }
- W1978830897 endingPage "208" @default.
- W1978830897 startingPage "195" @default.
- W1978830897 abstract "The ends of chromosomes (telomeres) consist of tandem repeats of guanine-rich sequences. In eukaryotics, telomeric DNA is single stranded for the final few hundred bases. These single-stranded sequences can fold into a variety of four-stranded structures (quadruplexes) held together by quartets of hydrogen-bonded guanine bases. The reverse transcriptase enzyme telomerase is responsible for maintaining telomeric DNA length in over 85% of cancer cells by catalyzing the synthesis of further telomeric repeats. Its substrate is the single-stranded 3′-telomeric end. Inhibition of telomere maintenance can be achieved by stabilization of a quadruplex structure for the telomere end. A variety of small molecules have been devised to achieve this, ranging from anthraquinones to porphyrins, acridines, and complex polycyclic systems. Structural and mechanistic aspects of these quadruplex complexes are reviewed here, together with a discussion of the issues of selectivity/potency for quadruplex DNAs vs duplex DNA. © 2001 John Wiley & Sons, Inc. Biopoly (Nucleic Acid Sci) 56: 195–208, 2001" @default.
- W1978830897 created "2016-06-24" @default.
- W1978830897 creator A5003587331 @default.
- W1978830897 creator A5023967587 @default.
- W1978830897 date "2000-01-01" @default.
- W1978830897 modified "2023-10-09" @default.
- W1978830897 title "G-quadruplexes as therapeutic targets" @default.
- W1978830897 cites W1496772673 @default.
- W1978830897 cites W1533210170 @default.
- W1978830897 cites W1579661837 @default.
- W1978830897 cites W1965959226 @default.
- W1978830897 cites W1967017947 @default.
- W1978830897 cites W1975502679 @default.
- W1978830897 cites W1978502771 @default.
- W1978830897 cites W1983023891 @default.
- W1978830897 cites W1983673827 @default.
- W1978830897 cites W1984934469 @default.
- W1978830897 cites W1986648841 @default.
- W1978830897 cites W1987046124 @default.
- W1978830897 cites W1991950644 @default.
- W1978830897 cites W1996101871 @default.
- W1978830897 cites W1996882901 @default.
- W1978830897 cites W1998647239 @default.
- W1978830897 cites W2000971601 @default.
- W1978830897 cites W2000977546 @default.
- W1978830897 cites W2002519680 @default.
- W1978830897 cites W2003842226 @default.
- W1978830897 cites W2007373812 @default.
- W1978830897 cites W2007759404 @default.
- W1978830897 cites W2007812774 @default.
- W1978830897 cites W2010595848 @default.
- W1978830897 cites W2011844193 @default.
- W1978830897 cites W2019724646 @default.
- W1978830897 cites W2020008177 @default.
- W1978830897 cites W2025811126 @default.
- W1978830897 cites W2026412740 @default.
- W1978830897 cites W2030976397 @default.
- W1978830897 cites W2032407757 @default.
- W1978830897 cites W2045702252 @default.
- W1978830897 cites W2046320299 @default.
- W1978830897 cites W2046892466 @default.
- W1978830897 cites W2048776061 @default.
- W1978830897 cites W2060017837 @default.
- W1978830897 cites W2060389234 @default.
- W1978830897 cites W2066029556 @default.
- W1978830897 cites W2067184067 @default.
- W1978830897 cites W2069356007 @default.
- W1978830897 cites W2073458757 @default.
- W1978830897 cites W2074134576 @default.
- W1978830897 cites W2074822663 @default.
- W1978830897 cites W2076956316 @default.
- W1978830897 cites W2078428995 @default.
- W1978830897 cites W2084246240 @default.
- W1978830897 cites W2093583881 @default.
- W1978830897 cites W2098871697 @default.
- W1978830897 cites W2106111891 @default.
- W1978830897 cites W2113987241 @default.
- W1978830897 cites W2115127516 @default.
- W1978830897 cites W2115346781 @default.
- W1978830897 cites W2115639078 @default.
- W1978830897 cites W2122199548 @default.
- W1978830897 cites W2123111989 @default.
- W1978830897 cites W2138586557 @default.
- W1978830897 cites W2143859021 @default.
- W1978830897 cites W2150788604 @default.
- W1978830897 cites W2153654013 @default.
- W1978830897 cites W2161982916 @default.
- W1978830897 cites W2164842045 @default.
- W1978830897 cites W2413251518 @default.
- W1978830897 cites W7448078 @default.
- W1978830897 doi "https://doi.org/10.1002/1097-0282(2000)56:3<195::aid-bip10009>3.0.co;2-5" @default.
- W1978830897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11745111" @default.
- W1978830897 hasPublicationYear "2000" @default.
- W1978830897 type Work @default.
- W1978830897 sameAs 1978830897 @default.
- W1978830897 citedByCount "192" @default.
- W1978830897 countsByYear W19788308972012 @default.
- W1978830897 countsByYear W19788308972013 @default.
- W1978830897 countsByYear W19788308972014 @default.
- W1978830897 countsByYear W19788308972015 @default.
- W1978830897 countsByYear W19788308972016 @default.
- W1978830897 countsByYear W19788308972017 @default.
- W1978830897 countsByYear W19788308972018 @default.
- W1978830897 countsByYear W19788308972019 @default.
- W1978830897 countsByYear W19788308972020 @default.
- W1978830897 countsByYear W19788308972021 @default.
- W1978830897 countsByYear W19788308972022 @default.
- W1978830897 countsByYear W19788308972023 @default.
- W1978830897 crossrefType "journal-article" @default.
- W1978830897 hasAuthorship W1978830897A5003587331 @default.
- W1978830897 hasAuthorship W1978830897A5023967587 @default.
- W1978830897 hasConcept C104317684 @default.
- W1978830897 hasConcept C156719811 @default.
- W1978830897 hasConcept C177336024 @default.
- W1978830897 hasConcept C185592680 @default.
- W1978830897 hasConcept C24107716 @default.
- W1978830897 hasConcept C2778301229 @default.
- W1978830897 hasConcept C512185932 @default.