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- W1978838187 abstract "The phytopathogenic fungus Magnaporthe oryzae is a major limiting factor in rice production. To understand the genetic basis of M. oryzae pathogenic development, we previously analyzed a library of T-DNA insertional mutants of M. oryzae, and identified ATMT0879A1 as one of the pathogenicity-defective mutants. Molecular analyses and database searches revealed that a single TDNA insertion in ATMT0879A1 resulted in functional interference with an annotated gene, MGG00056, which encodes a short-chain dehydrogenase/reductase (SDR). The mutant and annotated gene were designated as <TEX>$MoSDR1^{T-DNA}$</TEX> and MoSDR1, respectively. Like other SDR family members, MoSDR1 possesses both a cofactor-binding motif and a catalytic site. The expression pattern of MoSDR1 suggests that the gene is associated with pathogenicity and plays an important role in M. oryzae development. To understand the roles of MoSDR1, the deletion mutant <TEX>${Delta}Mosdr1$</TEX> for the gene was obtained via homology-dependent gene replacement. As expected, <TEX>${Delta}Mosdr1$</TEX> was nonpathogenic; moreover, the mutant displayed pleiotropic defects in conidiation, conidial germination, appressorium formation, penetration, and growth inside host tissues. These results suggest that MoSDR1 functions as a key metabolic enzyme in the regulation of development and pathogenicity in M. oryzae." @default.
- W1978838187 created "2016-06-24" @default.
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- W1978838187 date "2010-03-01" @default.
- W1978838187 modified "2023-10-01" @default.
- W1978838187 title "A Short-chain Dehydrogenase/reductase Gene is Required for Infection-related Development and Pathogenicity in Magnaporthe oryzae" @default.
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- W1978838187 doi "https://doi.org/10.5423/ppj.2010.26.1.008" @default.
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