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• W1978845479 abstract "CD8(+) T-lymphocytes from HIV-1 infected individuals express unidentified factors that suppress viral replication by inhibiting HIV-1 gene expression. We examined the role of epigenetics in modulating the HIV-1 suppressive factors expressed by primary CD8(+) T cells from subjects naturally controlling virus replication. HIV-1 suppression by CD8(+) T-lymphocytes was reversed up to 40% by the addition of a histone deacetylase (HDAC) inhibitor. Noncytolytic suppression was not dependent on epigenetic changes within the target cells, as HDAC1 within the target cell was dispensable, and HIV-1 LTR histone acetylation remained unchanged in the presence of CD8(+) T-lymphocytes. Histone deacetylation within CD8(+) T-lymphocytes was necessary for potent HIV-1 suppression. Blocking HDACs impairs the ability of CD8(+) T-lymphocytes to repress HIV-1 transcription, demonstrating that expression of a portion of the suppressive factors is regulated by epigenetics. These data provide a way to focus the search for the suppressive factors and to potentially modulate their expression." @default.
• W1978845479 created "2016-06-24" @default.
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• W1978845479 date "2010-09-01" @default.
• W1978845479 modified "2023-09-27" @default.
• W1978845479 title "Epigenetic regulation of CD8+ T-lymphocyte mediated suppression of HIV-1 replication" @default.
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• W1978845479 doi "https://doi.org/10.1016/j.virol.2010.06.001" @default.
• W1978845479 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3664273" @default.
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